公开(公告)号：US09173738B2

公开(公告)日：2015-11-03

申请号：US14095465

申请日：2013-12-03

Applicant: Medtronic, Inc.

Inventor： Robert J. Murray, III ,  Charles Tabor ,  Andrew Crisman ,  Adam Shipley

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2230/0054

Abstract: A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached includes a shaft assembly including a distal end, an intermediate portion, and a first coupling structure disposed near the distal end and configured to be coupled to a distal end of the prosthetic heart valve via a first tether. A sheath assembly defines a lumen sized to slidably receive the shaft assembly. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve. The first coupling structure is configured to be manipulated in a first direction to provide a controlled expansion or contraction of the distal end of the prosthetic heart valve.

Abstract translation: 一种与具有附接有阀结构的支架框架的假体心脏瓣膜一起使用的输送系统包括：轴组件，包括远端，中间部分和设置在远端附近的第一联接结构， 经由第一系绳的假体心脏瓣膜的远端。 护套组件限定尺寸为可滑动地容纳轴组件的内腔。 输送系统被配置成从其中护套组件包围假体心脏瓣膜的负载状态转变到其中护套组件从假体心脏瓣膜抽出的展开状态。 第一联接结构构造成在第一方向上被操纵以提供假体心脏瓣膜的远端的可控膨胀或收缩。

公开(公告)号：US20150025624A1

公开(公告)日：2015-01-22

申请号：US14505694

申请日：2014-10-03

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Glenn Stante ,  Adam Shipley

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2002/9505 ,  A61F2230/0054 ,  A61F2230/008

Abstract: A delivery device for percutaneously deploying a prosthetic valve includes a sheath, an inner shaft, and a release assembly. The release assembly is disposed between the sheath and the inner shaft, and includes a retraction member, a release member, and a retention member. The retraction member can self-retract in length from an extended condition to a retracted condition. The release member can self-expand from a compressed condition to an expanded condition. The retention member is distal the release member. In a delivery state, the sheath end is distal the retention member, the release member is in the compressed condition and the retraction member in the extended condition to retain the prosthesis. In a deployment state, the sheath end is positioned to permit the release member to self-transition to the expanded condition, allowing the retraction member to self-transition to the retracted condition and release the prosthesis.

Abstract translation: 用于经皮部署假性瓣膜的输送装置包括护套，内轴和释放组件。 释放组件设置在护套和内轴之间，并且包括缩回构件，释放构件和保持构件。 缩回构件可以从伸长状态自动缩回到缩回状态。 释放构件可以从压缩状态自膨胀到膨胀状态。 保持构件远离释放构件。 在输送状态下，护套端部处于保持构件的远侧，释放构件处于压缩状态，并且延伸构件处于延伸状态以保持假体。 在展开状态中，护套端部被定位成允许释放构件自我转变到扩张状态，允许收回构件自我转变到缩回状态并释放假体。

公开(公告)号：US20150018930A1

公开(公告)日：2015-01-15

申请号：US14503522

申请日：2014-10-01

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Hubert Yeung ,  Adam Shipley

IPC: A61F2/966

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2002/9505

Abstract: An attachment mechanism for coupling a stent to a delivery system is disclosed. The attachment mechanism is configured to pivot relative to an inner shaft assembly of the delivery system in order to release the stent from the delivery system.

Abstract translation: 公开了一种用于将支架耦合到输送系统的附接机构。 附接机构构造成相对于输送系统的内轴组件枢转，以将支架从输送系统释放。

公开(公告)号：US20140148889A1

公开(公告)日：2014-05-29

申请号：US13686311

申请日：2012-11-27

Applicant: MEDTRONIC, INC.

Inventor： Susheel Deshmukh ,  Siyan Som ,  Adam Shipley ,  Matthew Spurchise ,  Stephen Peter ,  Shishira Nagesh

IPC: A61F2/95

CPC classification number: A61F2/95 ,  A61B17/12022 ,  A61B17/12145 ,  A61B2017/00557 ,  A61B2017/1205 ,  A61F2/07 ,  A61F2/962 ,  A61F2/966 ,  A61F2002/072 ,  A61F2002/9505 ,  A61F2002/9522 ,  A61F2250/0098 ,  A61M25/0069 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/0183 ,  A61M2025/1093

Abstract: Distal tips for use with delivery catheters are disclosed that are configured to maintain complete engagement between the distal tip and a distal opening of a sheath component of the delivery catheter so as to prevent separation therebetween and/or to prevent fish-mouthing of a distal leading edge of the sheath component during in vivo use. Distal tips so configured realize one or more of the objectives of safer tracking of the delivery catheter through the vasculature, safe crossing of the delivery catheter through structural components of the vasculature and heart, such as through native valves, and safe removal of the delivery catheter post deployment.

Abstract translation: 公开了用于输送导管的远端尖端，其被构造成保持输送导管的护套部件的远侧末端和远侧开口之间的完全接合，以防止其间分离和/或防止远端引导 体内使用时鞘组分的边缘。 如此配置的远端提示实现通过脉管系统更安全地跟踪输送导管的一个或多个目标，通过脉管系统和心脏的结构部件（例如通过天然瓣膜）安全地穿过输送导管，并安全地移出输送导管 后部署。

公开(公告)号：US20220304805A1

公开(公告)日：2022-09-29

申请号：US17841965

申请日：2022-06-16

Applicant: Medtronic, Inc.

Inventor： Cynthia Clague ,  Scott Mosher ,  Marian Creaven ,  Declan Costello ,  Gavin Kenny ,  Michael Krivoruchko ,  Adam Shipley ,  Mark Torianni ,  Kshitija Garde ,  Eric Richardson

IPC: A61F2/24

Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

公开(公告)号：US10456254B2

公开(公告)日：2019-10-29

申请号：US15346843

申请日：2016-11-09

Applicant: Medtronic, Inc.

Inventor： Adam Shipley ,  John P. Shanahan ,  Andrew Crisman

IPC: A61F2/24 ,  A61F2/95

Abstract: A delivery system for percutaneously deploying a prosthetic heart valve. The system includes an inner shaft assembly, a delivery sheath capsule and a handle maintaining a first actuator and a second actuator. The capsule is configured to compressively retain the prosthetic heart valve over the inner shaft assembly. The first actuator is operated to proximally retract the delivery sheath capsule and expose the prosthetic heart valve relative to the capsule. The second actuator is operated to proximally retract the prosthetic heart valve by transmitting forces to the inner shaft assembly.

公开(公告)号：US20170049569A1

公开(公告)日：2017-02-23

申请号：US15346843

申请日：2016-11-09

Applicant: Medtronic, Inc.

Inventor： Adam Shipley ,  John P. Shanahan ,  Andrew Crisman

IPC: A61F2/24

Abstract: A delivery system for percutaneously deploying a prosthetic heart valve. The system includes an inner shaft assembly, a delivery sheath capsule and a handle maintaining a first actuator and a second actuator. The capsule is configured to compressively retain the prosthetic heart valve over the inner shaft assembly. The first actuator is operated to proximally retract the delivery sheath capsule and expose the prosthetic heart valve relative to the capsule. The second actuator is operated to proximally retract the prosthetic heart valve by transmitting forces to the inner shaft assembly.

Abstract translation: 用于经皮部署假性心脏瓣膜的输送系统。 该系统包括内轴组件，输送护套胶囊和保持第一致动器和第二致动器的手柄。 胶囊构造成将假体心脏瓣膜压缩地保持在内轴组件上。 第一致动器被操作以向近端缩回输送护套胶囊并相对于胶囊暴露假体心脏瓣膜。 操作第二致动器以通过将力传递到内轴组件来近侧缩回假体心脏瓣膜。

公开(公告)号：US09522063B2

公开(公告)日：2016-12-20

申请号：US14641679

申请日：2015-03-09

Applicant: Medtronic, Inc.

Inventor： Adam Shipley ,  John P. Shanahan ,  Andrew Crisman

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/243 ,  A61F2002/9517 ,  A61F2002/9534

Abstract: A delivery system for percutaneously deploying a prosthetic heart valve. The system includes an inner shaft assembly, a delivery sheath capsule and a handle maintaining a first actuator and a second actuator. The capsule is configured to compressively retain the prosthetic heart valve over the inner shaft assembly. The first actuator is operated to proximally retract the delivery sheath capsule and expose the prosthetic heart valve relative to the capsule. The second actuator is operated to proximally retract the prosthetic heart valve by transmitting forces to the inner shaft assembly.

公开(公告)号：US20150173895A1

公开(公告)日：2015-06-25

申请号：US14641679

申请日：2015-03-09

Applicant: Medtronic, Inc.

Inventor： Adam Shipley ,  John P. Shanahan ,  Andrew Crisman

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/243 ,  A61F2002/9517 ,  A61F2002/9534

Abstract: A delivery system for percutaneously deploying a prosthetic heart valve. The system includes an inner shaft assembly, a delivery sheath capsule and a handle maintaining a first actuator and a second actuator. The capsule is configured to compressively retain the prosthetic heart valve over the inner shaft assembly. The first actuator is operated to proximally retract the delivery sheath capsule and expose the prosthetic heart valve relative to the capsule. The second actuator is operated to proximally retract the prosthetic heart valve by transmitting forces to the inner shaft assembly.

Abstract translation: 用于经皮部署假性心脏瓣膜的输送系统。 该系统包括内轴组件，输送护套胶囊和保持第一致动器和第二致动器的手柄。 胶囊构造成将假体心脏瓣膜压缩地保持在内轴组件上。 第一致动器被操作以向近端缩回输送护套胶囊并相对于胶囊暴露假体心脏瓣膜。 操作第二致动器以通过将力传递到内轴组件来近侧缩回假体心脏瓣膜。

公开(公告)号：US20150148898A1

公开(公告)日：2015-05-28

申请号：US14603823

申请日：2015-01-23

Applicant: Medtronic, Inc.

Inventor： Michael Krivoruchko ,  Adam Shipley

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2403 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2250/0069

Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the stent which includes a plurality of self-expanding struts and an annular sealing membrane. Each strut has a first end coupled to a distal end of the stent and a second end not coupled to the stent. Each anti-paravalvular leakage component is moveable between a compressed configuration and a deployed configuration. In the compressed configuration, each strut extends distally away from the distal end of the stent. In the deployed configuration, each strut extends proximally away from the distal end of the stent. In an embodiment hereof, the deployed strut has a C-shape and is twisted such that the C-shape lies in a plane substantially along or tangential with the outer surface of the stent. In another embodiment hereof, the deployed strut is rolled-up and extends radially away from the outer surface of the stent.

Abstract translation: 经导管瓣膜假体包括可扩张的管状支架，支架内的假体瓣膜，以及耦合到环绕支架并包围多个自膨胀支柱和环形密封膜的抗瓣膜泄漏部件。 每个支柱具有联接到支架的远端的第一端和未联接到支架的第二端。 每个反paravalvular泄漏组件可在压缩配置和部署配置之间移动。 在压缩构型中，每个支柱远离支架远端延伸。 在展开的构造中，每个支柱向近端延伸远离支架的远端。 在本发明的一个实施例中，所展开的支柱具有C形并且被扭曲，使得C形位于与支架的外表面基本上沿或相切的平面中。 在本发明的另一个实施例中，部署的支柱被卷起并且从支架的外表面径向延伸。