公开(公告)号：US20230355987A1

公开(公告)日：2023-11-09

申请号：US18131500

申请日：2023-04-06

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  ShaileshKumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61N1/36 ,  A61N1/02 ,  A61N1/05

CPC classification number: A61N1/36185 ,  A61N1/025 ,  A61N1/36053 ,  A61N1/0558

Abstract: Systems and methods for stimulating an anatomical element are provided. The system may comprise an implantable pulse generator configured to generate a current and an electrode device comprising a plurality of electrodes configured to apply the current to the anatomical element. Each of the plurality of electrodes may comprise at least one of an anode or a cathode. The electrode device may be customized by assigning each of the plurality of electrodes as at least one of an anode or a cathode and at least one of active or inactive. The current may be applied to the anatomical element in a predetermined pattern using the plurality of electrodes.

公开(公告)号：US20230355982A1

公开(公告)日：2023-11-09

申请号：US18132232

申请日：2023-04-07

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  ShaileshKumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61N1/36 ,  A61N1/02 ,  A61N1/05

CPC classification number: A61N1/36139 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/36053

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, the system may include a device configured to generate a current (e.g., implantable pulse generator), a first electrode device configured to apply the current to the anatomical element, and a second electrode device configured to record one or more response measurements associated with applying the current to the anatomical element. In some examples, the one or more response measurements may be used to generate growth curves associated with applying the current to the anatomical element, where the growth curves can be used to adjust one or more parameters of the current. Additionally, the one or more response measurements may include an evoked compound action potential (eCAP) measurement, an electromyography (EMG) measurement, a glucose level measurement, or a combination thereof.

公开(公告)号：US20230355981A1

公开(公告)日：2023-11-09

申请号：US18131592

申请日：2023-04-06

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  Shaileshkumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/36053

Abstract: A system is provided herein for stimulating an anatomical element of a patient. For example, a device may be configured to generate a current, and an electrode device coupled to the device may be configured to apply the current to the anatomical element. In some examples, the current may be configured to prevent hypoglycemic episodes from occurring in the patient when applied to the anatomical element. For example, the current may be configured to downregulate neural activity of a celiac vagal trunk and to upregulate neural activity of a hepatic vagal trunk. Accordingly, the current being applied to anatomical element of the patient may result in a decrease in insulin production of the patient, an increase in glucose production of the patient, an increase in blood sugar levels of the patient, or a combination thereof. Additionally, applying the current may prevent nocturnal hypoglycemic episodes from occurring.

公开(公告)号：US20230355976A1

公开(公告)日：2023-11-09

申请号：US18131576

申请日：2023-04-06

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  ShaileshKumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/145

CPC classification number: A61N1/36053 ,  A61N1/0556 ,  A61B5/14532

Abstract: A system is provided herein for stimulating an anatomical element of a patient to regulate insulin production of the patient. In some examples, the system may include a device configured to generate a current and an electrode device electrically coupled to the device. Subsequently, the device may receive instructions to apply the current to the anatomical element via a plurality of electrodes of the electrode device, where the current is configured to regulate insulin production of the patient. For example, a first electrode may be configured for placement on or around a celiac vagal trunk, where the current downregulates neural activity of the celiac vagal trunk, and a second electrode may be configured for placement on or around a hepatic vagal trunk, where the current upregulates neural activity of the hepatic vagal trunk.

公开(公告)号：US20230355975A1

公开(公告)日：2023-11-09

申请号：US18131555

申请日：2023-04-06

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  ShaileshKumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61N1/36

CPC classification number: A61N1/36053 ,  A61N1/36146

Abstract: A system is provided herein for stimulating an anatomical element of a patient to achieve glycemic control for the patient. In some examples, the system may include a device configured to generate a current and an electrode device electrically coupled to the device that includes a plurality of electrodes configured for placement on or around the anatomical element. The device may receive instructions to apply the current to the anatomical element via the plurality of electrodes of the electrode device. Additionally, the current may be applied using a first waveform of a plurality of waveforms that the device is capable of generating, where each of the plurality of waveforms comprise a substantially similar charge density. Additionally or alternatively, a system is provided that provides a pharmacological blockade at the anatomical element using a micropump that is configured to deliver a pharmacological agent to the anatomical element to achieve glycemic control.

公开(公告)号：US20230355244A1

公开(公告)日：2023-11-09

申请号：US18131513

申请日：2023-04-06

Applicant: Medtronic, Inc.

Inventor： Maneesh Shrivastav ,  ShaileshKumar V. Musley ,  Kanthaiah Koka ,  Steven M. Goetz ,  Suryakiran Vadrevu ,  Rebecca K. Gottlieb ,  David John Miller ,  Leonid M. Litvak

IPC: A61B17/135

CPC classification number: A61B17/1355 ,  A61B2017/00867

Abstract: Systems and methods for mechanically blocking a nerve are provided. The system may comprise a blocking device configured to selectively compress the nerve. The system may also comprise a feedback mechanism configured to measure a response correlating to whether the nerve is blocked. When the blocking device compresses the nerve, a response from the feedback mechanism is received that correlates to the nerve being blocked or unblocked after a period of time.

公开(公告)号：US20220362557A1

公开(公告)日：2022-11-17

申请号：US17663350

申请日：2022-05-13

Applicant: Medtronic, Inc.

Inventor： Shailesh Kumar V. Musley ,  Maneesh Shrivastav ,  Abhijit Kadrolkar ,  Todd J. Sheldon ,  Vinod Sharma

IPC: A61N1/365 ,  A61N1/372 ,  A61B5/00 ,  A61B5/053 ,  A61B5/07

Abstract: A system comprises an implantable medical device configured to generate temperature data and impedance data associated with temperature and impedance of a patient proximate to the implantable medical device. The system further comprises processing circuitry configured to determine whether a first one or more infection criteria are satisfied by temperature data and impedance data generated by the implantable medical device during a first time interval, wherein the first one or more infection criteria include at least one criterion indicative of decreased impedance, determine whether a second one or more infection criteria are satisfied by the temperature data and impedance data generated by the implantable medical device during a second time interval subsequent to the first time interval, wherein the second one or more infection criteria include at least one criterion indicative of increased impedance, and output, based on satisfaction of the first and second infection criteria, an indication of infection.