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    MULTI-MODE INFLATABLE LIMB OCCLUSION DEVICES AND METHODS
    2.
    发明申请
    MULTI-MODE INFLATABLE LIMB OCCLUSION DEVICES AND METHODS 审中-公开

    公开(公告)号：US20180049748A1

    公开(公告)日：2018-02-22

    申请号：US15798314

    申请日：2017-10-30

    申请人： LifeCuff Technologies Inc.

    发明人： Boris Leschinsky

    IPC分类号： A61B17/135 ,  A61B5/022 ,  A61B5/0225 ,  A61B5/00 ,  A61B5/11

    CPC分类号： A61B17/1355 ,  A61B5/0002 ,  A61B5/02225 ,  A61B5/02233 ,  A61B5/0225 ,  A61B5/1112

    摘要： Methods for adaptive cuff inflation for the purposes of occluding a limb of a subject include inflating a cuff to a pressure at or above limb occlusion pressure and periodically deflating the cuff to detect amplitude of oscillometric oscillations reaching or exceeding a predetermined threshold, whereby indicating that the cuff pressure has reached an updated systolic blood pressure. Selecting the cuff to be wide enough to define limb occlusion pressure at or below the systolic blood pressure assures that this maneuver does not compromise cessation of blood flow to the limb. Devices are disclosed configured to operate in at least two of the following three operating modes: a tourniquet mode, a remote conditioning mode and a blood pressure monitoring mode.

    Methods and Devices to Reduce Damaging Effects of Concussive or Blast Forces on a Subject
    5.
    发明申请
    Methods and Devices to Reduce Damaging Effects of Concussive or Blast Forces on a Subject 审中-公开
    减少冲击力或爆炸力对受试者的伤害作用的方法和装置

    公开(公告)号：US20160317159A1

    公开(公告)日：2016-11-03

    申请号：US15150243

    申请日：2016-05-09

    申请人： TBI Innovations, LLC ,  Thornhill Research, Inc.

    发明人： David Smith ,  Joseph A. Fisher

    IPC分类号： A61B17/132 ,  A61F5/30 ,  A61B90/00 ,  A61B17/135

    CPC分类号： A61B17/1325 ,  A61B17/135 ,  A61B17/1355 ,  A61B90/08 ,  A61B2017/00119 ,  A61B2017/00734 ,  A61B2090/0807 ,  A61F5/30

    摘要： A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function

    摘要翻译： 用于减少爆炸或震荡事件的破坏性影响的方法和装置包括在震荡事件发生期间对至少一个颈静脉施加压力以减少来自颅腔的血液的流出。 从颅腔减少血液流量会增加脑脊液的颅内压，以减少创伤性脑损伤和脊柱损伤的风险。 减少血液流量进一步增加颅内压，从而增加耳蜗液，玻璃体液和脑脊液的压力，从而降低内耳损伤，眼内部结构和脊柱的风险。 此外，增加颅内压降低了脑损伤的可能性和任何相关的嗅觉功能丧失

    Personalized Tourniquet Apparatus
    8.
    发明申请
    Personalized Tourniquet Apparatus 有权
    个性化止血带装置

    公开(公告)号：US20160008005A1

    公开(公告)日：2016-01-14

    申请号：US14696401

    申请日：2015-04-25

    申请人： Western Clinical Engineering Ltd.

    发明人： James A. McEwen ,  Michael Jameson ,  Jeswin Jeyasurya ,  Kenneth L. Glinz

    IPC分类号： A61B17/135 ,  A61B5/022

    CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/02233 ,  A61B17/132 ,  A61B17/1322 ,  A61B17/135 ,  A61B90/92 ,  A61B90/98 ,  A61B2017/00017 ,  A61B2017/00022 ,  A61B2017/00119 ,  A61B2017/00199 ,  A61B2090/0807 ,  A61B2505/05

    摘要： Disclosed is a method and apparatus for regulating tourniquet cuff pressure based on a personalized tourniquet pressure (PTP) to facilitate safe performance of a surgical procedure. The apparatus includes a dual-purpose tourniquet cuff adapted to encircle a region of a patient limb to provide both a sensor during a pre-surgical time period and an effector during a surgical time period. An effector module communicates pneumatically with an inflatable bladder of the cuff for maintaining pressure in the bladder near a PTP during the surgical time period to safely stop penetration of arterial blood past the cuff. A pulsation sensor that communicates pneumatically with the inflatable bladder during the pre-surgical time period senses and characterizes pressure pulsations that are indicative of penetration of arterial blood into the region of the limb encircled by the cuff. A PTP estimator is responsive to the pulsation sensor for producing an estimate of the PTP, such that the estimate of the PTP is a function of the sensed pulsations.

    摘要翻译： 公开了一种用于基于个性化止血带压力（PTP）来调节止血带袖带压力以促进外科手术的安全性能的方法和装置。 该装置包括适于环绕病人肢体区域的双重目的的止血带，以在手术时期期间提供传感器，并在外科手术时间期间提供效能器。 效应器模块与袖带的可充气膀胱气动连通，用于在手术时间段内保持靠近PTP的膀胱中的压力，以安全地阻止动脉血穿过袖带。 在手术前时间段内气动与气囊连通的脉动传感器感测和表征压力脉动，其指示动脉血进入由袖带围绕的肢体区域。 PTP估计器响应于脉动传感器以产生PTP的估计，使得PTP的估计是所感测的脉动的函数。

    Optimal Remote Ischemic Preconditioning (ORIP) for mitigating DNA damage
    9.
    发明申请
    Optimal Remote Ischemic Preconditioning (ORIP) for mitigating DNA damage 审中-公开
    用于减轻DNA损伤的最佳远程缺血预处理（ORIP）

    公开(公告)号：US20150265286A1

    公开(公告)日：2015-09-24

    申请号：US14222744

    申请日：2014-03-24

    申请人： Fazal Raheman

    发明人： Fazal Raheman

    IPC分类号： A61B17/135

    CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/412 ,  A61B5/413 ,  A61B2017/00199 ,  A61B2017/00221

    摘要： DNA damage commonly results from exposure to diagnostic and therapeutic use of ionizing radiation, chemotoxic agents, smoking, diet and even from sedentary lifestyle. It is also a function of aging. Unrepaired DNA damage may result in accelerated aging and various forms of cancers. The invention discloses a method to harness the innate power of repetitive transient ischemia and reperfusion for protecting organs against imminent DNA damage, prevent senescence (aging) and for boosting DNA repair. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate/deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. ORIP can be self-administered and remotely monitored by clinician. ORIP may also be deployed as an adjunct in radiotherapy and chemotherapy for reducing the damage to normal tissue and boosting the treatment efficacy. The apparatus delivers maximal ORIP dose in shortest possible time.

    摘要翻译： DNA损伤通常来自暴露于电离辐射，化学毒物，吸烟，饮食甚至久坐生活方式的诊断和治疗用途。 它也是老化的功能。 未修复的DNA损伤可能导致加速老化和各种形式的癌症。 本发明公开了一种利用重复性短暂性脑缺血再灌注的先天功能来保护器官免受即将发生的DNA损伤，防止衰老（老化）和促进DNA修复的方法。 这种最佳远程缺血预处理（ORIP）的方法包括利用一对可编程的气动袖带，以预定义的时间间隔对每个肢体交替地封闭血液循环进行充气/放气。 ORIP可以由临床医生进行自我管理和远程监控。 也可以将ORIP作为放射治疗和化学疗法的辅助部件，以减少对正常组织的损伤并提高治疗效果。 该设备在最短的时间内提供最大的ORIP剂量。