公开(公告)号：US20210055287A1

公开(公告)日：2021-02-25

申请号：US17090367

申请日：2020-11-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N33/543 ,  B01L3/00 ,  B01L9/00 ,  C12Q1/00 ,  G01N27/30 ,  G01N21/76 ,  B01J19/00

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

公开(公告)号：US20160356722A1

公开(公告)日：2016-12-08

申请号：US15222674

申请日：2016-07-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N21/76 ,  C12Q1/00 ,  B01L9/00 ,  G01N33/543 ,  B01J19/00

CPC classification number: G01N21/76 ,  B01J19/0046 ,  B01J2219/00653 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/5029 ,  B01L9/527 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0688 ,  B33Y80/00 ,  C12Q1/001 ,  C40B40/10 ,  G01N27/30 ,  G01N33/5438 ,  G01N2458/30 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。

公开(公告)号：US20140336070A1

公开(公告)日：2014-11-13

申请号：US14319167

申请日：2014-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: G01N33/573 ,  G01N33/53 ,  G01N21/76 ,  G01N33/58

CPC classification number: G01N33/573 ,  C12Q1/485 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N2333/91205 ,  G01N2458/30 ,  G01N2458/40 ,  Y10S435/967 ,  Y10S435/968 ,  Y10T436/10 ,  Y10T436/108331

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

Abstract translation: 本发明涉及使用磷酸化特异性抗体和基本上不含无机磷酸盐的缓冲组合物的磷酸化肽或蛋白质的改进的电化学发光测定方法。