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公开(公告)号：US20100048454A1
公开(公告)日：2010-02-25
申请号：US11632808
申请日：2005-08-03
申请人： Ehud Arbit , Steven Dinh , Michael Goldberg
发明人： Ehud Arbit , Steven Dinh , Michael Goldberg
CPC分类号： A61K38/28 , A61K31/155 , A61K2300/00
摘要： Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or HbAlc levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes.
摘要翻译： 公开了包括胰岛素，促进胰岛素以治疗有效量转运至血液的递送剂和双胍，例如二甲双胍的药物剂型，用于口服给患者治疗糖尿病。 还公开了用于在糖尿病哺乳动物中实现改善的葡萄糖耐量和血糖控制的方法，而没有任何统计学显着的重量增加，低血糖或高胰岛素血症的风险，以及监测血糖浓度或HbAlc水平的需要，以及用于降低发生率和/ 或与慢性给药胰岛素相关的一种或多种疾病状态的严重程度; 用于预防性保护（3细胞功能或用于预防（葡萄糖耐量降低或早期糖尿病）的哺乳动物中的3细胞死亡或功能障碍;以及用于长期保护以发展（或延迟发作）明显或胰岛素依赖性 具有葡萄糖耐量降低或早期糖尿病的哺乳动物的糖尿病。
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公开(公告)号：US20090318331A1
公开(公告)日：2009-12-24
申请号：US12546283
申请日：2009-08-24
申请人： Ehud ARBIT , Michael Goldberg , Shingal Majuru
发明人： Ehud ARBIT , Michael Goldberg , Shingal Majuru
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61B5/14532 , A61K31/192 , A61K38/00
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.
摘要翻译： 用于治疗哺乳动物葡萄糖耐量异常和早期和晚期糖尿病的方法，用于预防性节省β-细胞功能，有助于预防β-细胞死亡，预防2型糖尿病哺乳动物的明显糖尿病发作，治疗目前的水平 具有葡萄糖耐量降低或糖尿病的哺乳动物的血糖控制功能障碍，包括在摄食之前或之后约10分钟内口服胰岛素和促进胰岛素从胃肠道吸收的输送剂 ，长期的。 除了施用快速作用的胰岛素以提供第一胰岛素峰之外，所述方法还包括施用缓慢作用的胰岛素以提供在稍后时间但持续时间更长的时间发生的第二胰岛素峰。 这些方法可以改善血糖控制，没有低血糖，高胰岛素血症和体重增加的风险，以及通常与胰岛素治疗相关的频繁血糖监测的需要。
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公开(公告)号：US20050203001A1
公开(公告)日：2005-09-15
申请号：US11072941
申请日：2005-03-04
申请人： Ehud Arbit , Michael Goldberg , Shingai Majuru
发明人： Ehud Arbit , Michael Goldberg , Shingai Majuru
IPC分类号： A61K38/28
CPC分类号： A61K38/28 , A61B5/14532 , A61K31/192 , A61K38/00
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.
摘要翻译： 用于治疗哺乳动物葡萄糖耐量异常和早期和晚期糖尿病的方法，用于预防性节省β-细胞功能，有助于预防β-细胞死亡，预防2型糖尿病哺乳动物的明显糖尿病发作，治疗目前的水平 具有葡萄糖耐量降低或糖尿病的哺乳动物的血糖控制功能障碍，包括在摄食之前或之后约10分钟内口服胰岛素和促进胰岛素从胃肠道吸收的输送剂 ，长期的。 除了施用快速作用的胰岛素以提供第一胰岛素峰之外，所述方法还包括施用缓慢作用的胰岛素以提供在稍后时间但持续时间更长的时间发生的第二胰岛素峰。 这些方法可以改善血糖控制，没有低血糖，高胰岛素血症和体重增加的风险，以及通常与胰岛素治疗相关的频繁血糖监测的需要。
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公开(公告)号：US20240353176A1
公开(公告)日：2024-10-24
申请号：US18641203
申请日：2024-04-19
申请人： Michael Goldberg
发明人： Michael Goldberg
CPC分类号： F26B25/006 , F26B3/04
摘要： Methods, apparatuses, and systems for a closed loop product drying process are disclosed. Heated dry air enters a drying chamber, extracts moisture from a product to be dried, and exits the drying chamber, cooler and wetter. A heat pump air handler dries and warms the air from the drying chamber exhaust, and returns it to the drying chamber, in a closed air loop. The heat pump air handler includes a dehumidifier means in the closed air loop flow path. The dehumidifier means removes entrained moisture from wet air exiting the drying chamber, reheats the air, and returns it to the drying chamber.
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公开(公告)号：US20120153691A1
公开(公告)日：2012-06-21
申请号：US13404857
申请日：2012-02-24
申请人： Michael Goldberg , Ruth Timme
发明人： Michael Goldberg , Ruth Timme
IPC分类号： B60N2/28
摘要： A child car seat subframe that is easily disassembled into component sections for washing within a residential-sized dishwasher. The car seat subframe can be disassembled by hand, and each individual component is capable of fitting in a residential-sized dishwasher individually and collectively. The component sections are attached by a combination of registration tabs and slots, and held tightly together by fasteners, or attached by a combination of tongue and groove joints. Hanging devices, such as hooks, may be formed on one side of each component section to facilitate hanging on racks in a dishwasher. The car seat subframe back panel and side panels are disassembled into a plurality of segments for easily fitting in a dishwasher.
摘要翻译： 一个儿童汽车座椅子框架，容易拆卸成部件，用于在住宅大小的洗碗机内进行清洗。 汽车座椅子框架可以手动拆卸，每个单独的部件都可以单独和集体地安装在住宅尺寸的洗碗机中。 组件部分通过配准片和槽的组合连接，并通过紧固件紧紧地保持在一起，或者通过舌和槽接头的组合来附接。 可以在每个部件部分的一侧上形成诸如钩子的悬挂装置，以便于挂在洗碗机中的机架上。 汽车座椅副翼后面板和侧板被分解成多个段，以容易地装配在洗碗机中。
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公开(公告)号：US20100223682A1
公开(公告)日：2010-09-02
申请号：US12649489
申请日：2009-12-30
申请人： Yitzhak Katz , Michael Goldberg
发明人： Yitzhak Katz , Michael Goldberg
CPC分类号： C07K14/4732 , A01K2267/01 , A61K38/00
摘要： This invention provides an altered kosher kappa casein polypeptide having at least one altered amino acid in a defined amino acid stretch. The defined amino acid stretch contributes to an allergic reaction induced by a kosher wild-type casein polypeptide in a human subject. Moreover, the defined amino acid stretch is expressed solely in kosher animals. The invention further provides an expression system for expressing the altered kosher casein polypeptide.
摘要翻译： 本发明提供了在限定的氨基酸延伸中具有至少一个改变的氨基酸的改变的犹太人κ酪蛋白多肽。 所定义的氨基酸伸展有助于由人类受试者中的犹太野生型酪蛋白多肽诱导的过敏反应。 此外，定义的氨基酸伸展仅在犹太人动物中表达。 本发明还提供了用于表达改变的乳清酪蛋白多肽的表达系统。
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公开(公告)号：US06308711B1
公开(公告)日：2001-10-30
申请号：US09390857
申请日：1999-09-03
申请人： Michael Goldberg
发明人： Michael Goldberg
IPC分类号： A61F900
CPC分类号： A61F9/02
摘要： The invention includes a protective eye device for an oral treatment patient including an eyepiece having bridge portions that form a seal with the nose. The bridge portions are a fulcrum between attachment portions that extend downwardly and outwardly from the bridge portions, and upper portions disposed above the bridge portions. A retaining member is coupled to the attachment portions below the fulcrum such that tension on the retaining member causes the attachment portions to extend toward the face and facilitates the sealing relationship between a lower rim and a middle surface of the face between the eyes and mouth. The tension on the retaining member simultaneously causes the upper portions to extend away from the face, and facilitates the spatial relationship, or a gap, between the forehead and an upper rim. The invention also includes a method for shielding the eyes of a patient.
摘要翻译： 本发明包括用于口腔治疗患者的保护眼装置，包括具有与鼻子形成密封的桥接部分的目镜。 桥接部分是从桥接部分向下和向外延伸的连接部分之间的支点，以及设置在桥接部分上方的上部。 保持构件联接到支点下方的附接部分，使得保持构件上的张力使得附接部分朝向脸部延伸，并且有助于眼睛和嘴部之间的脸部的下边缘和中间表面之间的密封关系。 保持构件上的张力同时导致上部部分远离面部延伸，并且有利于前额与上缘之间的空间关系或间隙。 本发明还包括一种屏蔽患者眼睛的方法。
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公开(公告)号：US6140315A
公开(公告)日：2000-10-31
申请号：US89198
申请日：1998-06-05
IPC分类号： A61K31/4172 , A61K38/09 , A61K31/56 , A61K31/535
CPC分类号： A61K31/4172 , A61K38/09
摘要： A method of decreasing atherosclerosis and its complications, such as myocardial infarction, stroke and peripheral vascular disease, wherein the method involves administering to a human or an animal an amount of goserelin acetate sufficient to decrease atherosclerosis and its complications.
摘要翻译： 一种降低动脉粥样硬化及其并发症的方法，例如心肌梗塞，中风和外周血管疾病，其中该方法包括向人或动物施用足量降低动脉粥样硬化及其并发症的量的醋酸戈舍瑞林。
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19.发明授权
公开(公告)号：US5416569A
公开(公告)日：1995-05-16
申请号：US637469
申请日：1991-01-04
申请人： Michael Goldberg
发明人： Michael Goldberg
CPC分类号： G03G15/1625 , G03G13/08 , G03G15/6585 , G03G15/6591 , G03G5/0211 , G03G9/0926 , G03G9/09708 , H05K3/1266 , H05K2203/0517
摘要： Devices having conductive paths are fabricated by electrographically transferring conductive toner to an insulative copy sheet imaging desired conductive paths graphically represented by an electromagnetic signal. A system for making devices having electrically conductive paths corresponding to those graphically represented on a mask has an electrographic machine having electrically conductive toner and a bonder for bonding the electrically conductive toner to a copy sheet. An insulative copy sheet is configured to pass through the electrographic machine bonder and receive the electrically conductive toner only on paths corresponding to those graphically represented on the mask. The electrically conductive toner has a conductivity sufficiently high so as to provide electrically conductive paths along a copy sheet bearing an electrographically transferred image of the mask with the electrically conductive toner bonded to the copy sheet along the electrically conductive paths with the resistance between points along the conductive paths being many times less than that of regions adjacent to the electrically conductive paths.
摘要翻译： 具有导电路径的装置通过将导电调色剂电导转印到由电磁信号图形表示的期望导电路径的绝缘复印纸上制造。 用于制造具有对应于在掩模上图形表示的导电路径的器件的器件的系统具有具有导电调色剂的电摄影机和用于将导电调色剂粘合到复印纸上的接合器。 绝缘复印纸被配置为通过电子照相机粘合机并仅在对应于在掩模上图形表示的那些路径上接收导电调色剂。 导电性调色剂具有足够高的导电性，以便沿着沿着导电路径粘合到复印纸的导电调色剂沿着沿着沿着导电路径的点之间的电阻沿着沿着沿着导电路径的点之间的电阻 导电路径比与导电路径相邻的区域的导电路径小很多倍。
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公开(公告)号：US09675766B2
公开(公告)日：2017-06-13
申请号：US14343085
申请日：2012-09-05
申请人： Steven Goldberg , Michael Goldberg , David Schiff
发明人： Steven Goldberg , Michael Goldberg , David Schiff
CPC分类号： A61M5/422 , A61B90/30 , A61M5/50 , A61M37/0092 , A61M2205/587
摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.
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