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公开(公告)号：US07937160B2
公开(公告)日：2011-05-03
申请号：US11010232
申请日：2004-12-10
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/36082
摘要： Methods and kits for delivering an electrode lead into the head of a patient are provided. A burr hole is formed within the cranium of the patient, and an electrode lead is threaded through the burr hole. The electrode lead is then placed in a pre-shaped two-dimensional geometry between the cranium and cortical brain tissue of the patient. An access anchor may be mounted into the burr hole to facilitate introduction and removal of the electrode lead and other devices. In some circumstances, it may be desirable to separate the dura mater overlying the cortical brain tissue from the cortical brain tissue to create a pocket in which the electrode lead may be manipulated. In this case, a tissue layer dissection device can be introduced through the burr hole, operated to separate the dura mater from the cranium, and then removed from the burr hole. In one embodiment, the dissection device comprises a balloon that can be inflated to separate the dura mater and cranium, and then deflated prior to removing the dissection device from the burr hole.
摘要翻译： 提供了用于将电极引线输送到患者头部的方法和套件。 在患者的颅骨内形成有钻孔，电极引线穿过毛刺孔。 然后将电极引线置于患者的颅骨和皮质脑组织之间的预先形状的二维几何形状中。 可以将入口锚固件安装到钻孔中以便于引入和移除电极引线和其它装置。 在某些情况下，可能需要将覆盖皮质脑组织的硬膜与皮层脑组织分离，以产生可以操纵电极引线的口袋。 在这种情况下，可以通过毛刺孔引入组织层解剖装置，操作以将硬脑膜与头颅分开，然后从毛刺孔中取出。 在一个实施例中，解剖装置包括可以充气以分离硬脑膜和颅骨的气囊，然后在从毛刺孔移除解剖装置之前放气。
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公开(公告)号：US20100286655A1
公开(公告)日：2010-11-11
申请号：US12838934
申请日：2010-07-19
IPC分类号： A61M5/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。
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公开(公告)号：US08185208B2
公开(公告)日：2012-05-22
申请号：US12549223
申请日：2009-08-27
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译： 提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。 该试剂盒包括第一和第二医疗引线，例如刺激引线。 每个引线包括细长主体和至少一个操作元件。 第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。 该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内 第一个医疗领导。
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公开(公告)号：US20120059446A1
公开(公告)日：2012-03-08
申请号：US13230410
申请日：2011-09-12
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译： 提供医疗用铅和治疗患者的方法。 医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。 医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。 由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。 可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态 压缩力。
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公开(公告)号：US20090319012A1
公开(公告)日：2009-12-24
申请号：US12549223
申请日：2009-08-27
IPC分类号： A61N1/04
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译： 提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。 该试剂盒包括第一和第二医疗引线，例如刺激引线。 每个引线包括细长主体和至少一个操作元件。 第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。 该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内 第一个医疗领导。
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公开(公告)号：US07590454B2
公开(公告)日：2009-09-15
申请号：US10799271
申请日：2004-03-12
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译： 提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。 该试剂盒包括第一和第二医疗引线，例如刺激引线。 每个引线包括细长主体和至少一个操作元件。 第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。 该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿着第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内 第一个医疗领导。
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17.发明授权Method of stimulating/sensing brain with combination of intravascularly and non-vascularly delivered leads 有权通过血管内和非血管输送导联组合刺激/感觉脑的方法公开(公告)号：US07295875B2
公开(公告)日：2007-11-13
申请号：US10783679
申请日：2004-02-20
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36017 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a first electrical lead within the head of the patient, and non-vascularly delivering a second electrical lead within the head the patient. The vascular and intravascular leads are placed adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue). Optionally, the method comprises implanting a source of stimulation and/or recorder within the patient's body, and then electrically coupling the proximal ends of the electrical leads to the implanted device. Using the electrical leads, the brain tissue can then be stimulated and/or recorded in order to treat the neurological disorder.
摘要翻译： 提供了治疗患者神经障碍的方法。 该方法包括血管内传递患者头部内的第一电引线，并且在患者的头部内非血管输送第二电引线。 血管和血管内引线被放置在脑组织（例如皮质脑组织或深部脑组织）附近。 可选地，该方法包括在患者体内植入刺激源和/或记录器源，然后将电引线的近端电连接到植入装置。 使用电引线，然后可以刺激和/或记录脑组织以治疗神经障碍。
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公开(公告)号：US20120310270A1
公开(公告)日：2012-12-06
申请号：US13586280
申请日：2012-08-15
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译： 在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。 阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。 在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。 编织或网状结构由弹性材料制成。
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公开(公告)号：US08128614B2
公开(公告)日：2012-03-06
申请号：US12353112
申请日：2009-01-13
IPC分类号： A61M25/01
CPC分类号： A61M25/0662 , A61M25/10 , A61M2025/0006 , A61M2025/0293 , A61M2025/0681 , A61M2025/09125 , A61M2025/1063
摘要： An apparatus for accessing a site within a body includes a cannula and an elongate member. The cannula has a proximal end, a distal end, and a lumen extending therebetween. The elongate member has a distal end configured for insertion into the lumen, wherein the distal end of the elongate member is attachable to and releasable from the distal end of the cannula. A method for accessing a site within a body includes inserting a distal end of an elongate member into a lumen of a cannula, detachably attaching the distal end of the elongate member to the cannula, and steering a distal end of the cannula to a desired site using the elongate member.
摘要翻译： 用于进入体内部位的装置包括套管和细长构件。 套管具有近端，远端和在其间延伸的内腔。 细长构件具有构造成用于插入内腔的远端，其中细长构件的远端可附接到插管的远端并且可从插管的远端释放。 用于访问体内部位的方法包括将细长构件的远端插入套管的内腔，将细长构件的远端可拆卸地连接到套管上，并将套管的远端转向所需位置 使用细长构件。
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公开(公告)号：US07410482B2
公开(公告)日：2008-08-12
申请号：US10319379
申请日：2002-12-13
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61B17/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译： 在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。 阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。 在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。 编织或网状结构由弹性材料制成。
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