公开(公告)号：US20080139875A1

公开(公告)日：2008-06-12

申请号：US11635403

申请日：2006-12-07

申请人： Michael R. Tracey ,  Anthony DiUbaldi ,  Stephen Wahlgren ,  Rex O. Bare ,  Bradley J. Sargent

发明人： Michael R. Tracey ,  Anthony DiUbaldi ,  Stephen Wahlgren ,  Rex O. Bare ,  Bradley J. Sargent

IPC分类号： A61B5/00

CPC分类号： A61B5/14507 ,  A61B5/0031 ,  A61B5/205 ,  A61B5/208 ,  A61B5/6874 ,  A61B2562/028

摘要： An implantable urodynamic system includes an implantable first device deployable in a patient's bladder, an implantable second device deployable in a patient's vaginal canal, and a data acquisition and analysis module or processing unit external to the body of the patient. The first device includes a magnet and an inductive coil, and the second device includes a magnet, an inductive coil and a battery. When deployed in the patient's body, attraction between the magnets maintains the two devices in close proximity to one another to effect an inductive coupling between the coils so that the first device may be powered by the battery of the second device. The urodynamic system is intended to facilitate measurement, collection, and wireless transmission of real-time, or near real-time, data (bladder pressure, abdominal pressure, and temperature) from an ambulatory patient. This data is of value in diagnosing a number of abnormal bladder conditions, such as infection, overactive bladder, bladder spasms, and the like.

摘要翻译： 可植入尿动力系统包括可部署在患者膀胱中的可植入第一装置，可植入患者阴道内的可植入第二装置，以及在患者身体外部的数据采集和分析模块或处理单元。 第一装置包括磁体和感应线圈，并且第二装置包括磁体，感应线圈和电池。 当部署在患者体内时，磁体之间的吸引力将两个装置彼此紧密地保持在彼此附近以实现线圈之间的感应耦合，使得第一装置可以由第二装置的电池供电。 尿动力系统旨在便于来自流动患者的实时或近实时数据（膀胱压力，腹压和温度）的测量，收集和无线传输。 该数据在诊断膀胱膀胱状况异常，例如感染，膀胱过度活动症，膀胱痉挛等中是有价值的。

公开(公告)号：US07252631B2

公开(公告)日：2007-08-07

申请号：US10674452

申请日：2003-09-30

申请人： Michael R. Tracey

发明人： Michael R. Tracey

IPC分类号： A61F2/00 ,  A61B5/00

CPC分类号： A61B1/32 ,  A61B5/202 ,  A61B5/204 ,  A61B5/205 ,  A61B5/208 ,  A61B5/7435 ,  A61B2560/0443 ,  A61M2025/0002

摘要： A method is provided for diagnosing detrusor instability. The method includes using an insert member having a channel therethrough positioned distal of the urethral sphincter, creating a substantially fluid tight seal to substantially block fluid flow into or out of the urethral canal other than through the channel, infusing fluid from a fluid source through the channel in the insert member and into the urethral canal at a location distal of the urethral sphincter, and measuring a pressure within the urethral canal at a location distal of the urethral sphincter as the fluid is being infused therein. The infusing step further involves infusing fluid until the urethral sphincter opens, and thereafter until at least one detrusor contraction occurs.

摘要翻译： 提供了一种用于诊断逼尿肌不稳定性的方法。 该方法包括使用具有穿过其定位在尿道括约肌远端的通道的插入构件，产生基本上流体密封的密封，以基本阻止流体流入或流出尿道，而不是通过通道，将来自流体源的流体通过 通道在尿道括约肌远端的位置处进入尿道管，并且当尿液括约肌中注入流体时，在尿道括约肌远端位置测量尿道内的压力。 输注步骤还包括输注流体直到尿道括约肌打开，此后直到发生至少一次逼尿肌收缩。

公开(公告)号：US20070156012A1

公开(公告)日：2007-07-05

申请号：US11321659

申请日：2005-12-29

申请人： Michael R. Tracey ,  Steve Bell ,  Bryan Knodel

发明人： Michael R. Tracey ,  Steve Bell ,  Bryan Knodel

IPC分类号： A61F2/02

CPC分类号： A61F2/0045 ,  A61B17/0625 ,  A61B2017/00805 ,  A61F2/0036

摘要： A suburethral implant for treating stress urinary incontinence (SUI) includes an elongated plate-like member which is slightly curved in transverse cross-section, and a pair of spaced apart arms having hooked ends or barbs which extend from the plate-like member. A device for deploying the suburethral implant for treating SUI includes a vaginal probe for insertion in the vaginal canal of a patient, and a urethra locator probe for the simultaneous insertion in the urethra of a patient. The urethra probe is spaced apart from and overlies the vaginal probe. The vaginal probe includes a wall in which is formed an exit port. A suburethral implant introducer assembly is extendable and retractable through the exit port on the vaginal probe. The introducer assembly has a distal end on which is removably mounted a suburethral implant. The introducer assembly is extendable through the exit port to pierce the vaginal canal wall of the patient in order to position the suburethral implant in proximity to the patient's urethra. The hooked ends or barbs on the arms of the suburethral implant engage the tissue surrounding the patient's urethra and are affixed thereto during deployment of the implant. The introducer assembly is then retracted into the vaginal probe, whereby the implant is released from the introducer assembly and remains affixed to tissue in proximity to the patient's urethra.

摘要翻译： 用于治疗压力性尿失禁的尿道植入物（SUI）包括在横截面上略微弯曲的细长板状构件，以及一对间隔开的臂，其具有从板状构件延伸的钩端或倒钩。 用于部署用于治疗SUI的尿道植入物的装置包括用于插入患者阴道内的阴道探针和用于同时插入患者尿道的尿道定位器探针。 尿道探针与阴道探针间隔开并覆盖阴道探针。 阴道探针包括形成有出口的壁。 尿道植入物导引器组件可以通过阴道探针上的出口延伸和缩回。 导引器组件具有远端，其上可移除地安装有尿道植入物。 导引器组件可通过出口延伸以刺穿患者的阴道管壁，以将尿道植入物定位在患者的尿道附近。 尿道植入物的手臂上的钩状端或倒钩与患者尿道周围的组织接合，并在植入物展开过程中固定在其上。 导引器组件然后缩回到阴道探针中，由此植入物从导引器组件释放并且保持附着于患者尿道附近的组织。

公开(公告)号：US09139542B2

公开(公告)日：2015-09-22

申请号：US14198975

申请日：2014-03-06

申请人： Weijiang Zhang ,  Michael R. Tracey ,  Junning Lee

发明人： Weijiang Zhang ,  Michael R. Tracey ,  Junning Lee

IPC分类号： C07D277/40 ,  C07D277/593

CPC分类号： C07D277/40 ,  C07D277/593

摘要： The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.

摘要翻译： 本发明涉及（2Z）-2-（2-氨基-5-氯噻唑-4-基）-2-（3-N-叔丁氧基羰基氨基丙氧基亚氨基）乙酸的三乙胺盐的结晶形式。 本发明还涉及制备结晶形式的方法和中间体。 结晶形式可用作制备交联糖肽 - 头孢菌素抗生素的中间体。

公开(公告)号：US07056288B2

公开(公告)日：2006-06-06

申请号：US10183075

申请日：2002-06-27

申请人： Michael R. Tracey ,  Frederick T. Karl

发明人： Michael R. Tracey ,  Frederick T. Karl

IPC分类号： A61B1/32

CPC分类号： A61B1/32 ,  A61B5/202 ,  A61B5/204 ,  A61B5/205 ,  A61B5/208 ,  A61B5/7435 ,  A61B2560/0443 ,  A61M2025/0002

摘要： A vaginal speculum assembly is provided including an upper arm and a lower arm movably coupled to one another by a coupling member positioned at a posterior end. Each of the upper and lower arms are dimensioned for at least partial insertion into a patient's vagina, and when so inserted, are dimensioned to exert pressure on at least upper and lower portions of an inner surface of the patient's vaginal wall. The coupling member permits movement of the upper and lower arms relative to one another to adjust their positioning relative to the vaginal wall. The assembly further includes a locking device coupled to at least one of the upper and lower arms which, when activated, substantially prevents movement of the upper and lower arms relative to one another. A connector member extends outwardly from a posterior end of the upper arm. The connector member is configured to engage a predetermined portion of an insert device assembly including an insert member to be inserted into the patient's urethral canal, to thereby maintain the insert device assembly in position relative to the vaginal speculum assembly.

公开(公告)号：US07052452B2

公开(公告)日：2006-05-30

申请号：US10183790

申请日：2002-06-27

申请人： Ulf Ulmsten ,  Michael R. Tracey ,  Martin Nohilly

发明人： Ulf Ulmsten ,  Michael R. Tracey ,  Martin Nohilly

IPC分类号： A61F2/00 ,  A61M29/00

CPC分类号： A61B1/32 ,  A61B5/202 ,  A61B5/204 ,  A61B5/205 ,  A61B5/208 ,  A61B5/7435 ,  A61B2560/0443 ,  A61M2025/0002

摘要： A medical system is provided for assessing urinary function. The system includes a control device and at least one test module capable of being removably coupled to the control device such that, when coupled, the system is capable of performing a test to assess urinary function. The control device may include a processor and memory having stored therein a plurality of software subroutine, at least one of which directs a test to assess urinary function. The test module may include a module identification device, and the control device selects the software subroutine based upon information obtained from the module identification device. The test module may further include a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet and an insert member dimensioned for at least partial insertion into a patient's urinary tract and coupled to the first fluid outlet so that fluid infused through the first fluid conduit flows through the insert member.

公开(公告)号：US07970478B2

公开(公告)日：2011-06-28

申请号：US12317194

申请日：2008-12-19

申请人： Stephen Wahlgren ,  Michael R. Tracey

发明人： Stephen Wahlgren ,  Michael R. Tracey

IPC分类号： A61N1/00

CPC分类号： A61N1/36017 ,  A61B5/04001 ,  A61B5/04005 ,  A61B5/4041 ,  A61B5/6846 ,  A61B2560/0276 ,  A61N1/08

摘要： A method and system for optimizing stimulation therapy of an external stimulating device. The stimulating signal for stimulation of a target nerve is produced using the external stimulating device. A magnetic field is induced in an implanted transmitting coil disposed proximate the target nerve when the action potential is fired along an axon of the target nerve. In turn, a feedback signal is generated in a receiving coil associated with the external stimulating device based on whether the target nerve fires an action potential. Stimulating signal parameters of the stimulating signal are adjusted based on the feedback signal.

摘要翻译： 一种用于优化外部刺激装置的刺激治疗的方法和系统。 使用外部刺激装置产生用于刺激目标神经的刺激信号。 当沿靶神经的轴突发射动作电位时，在靠近目标神经设置的植入的发射线圈中诱发磁场。 反过来，基于目标神经是否触发动作电位，在与外部刺激装置相关联的接收线圈中产生反馈信号。 基于反馈信号调整刺激信号的刺激信号参数。

公开(公告)号：US20100161005A1

公开(公告)日：2010-06-24

申请号：US12317194

申请日：2008-12-19

申请人： Stephen Wahlgren ,  Michael R. Tracey

发明人： Stephen Wahlgren ,  Michael R. Tracey

IPC分类号： A61N1/36

CPC分类号： A61N1/36017 ,  A61B5/04001 ,  A61B5/04005 ,  A61B5/4041 ,  A61B5/6846 ,  A61B2560/0276 ,  A61N1/08

摘要： A method and system for optimizing stimulation therapy of an external stimulating device. The stimulating signal for stimulation of a target nerve is produced using the external stimulating device. A magnetic field is induced in an implanted transmitting coil disposed proximate the target nerve when the action potential is fired along an axon of the target nerve. In turn, a feedback signal is generated in a receiving coil associated with the external stimulating device based on whether the target nerve fires an action potential. Stimulating signal parameters of the stimulating signal are adjusted based on the feedback signal.

摘要翻译： 一种用于优化外部刺激装置的刺激治疗的方法和系统。 使用外部刺激装置产生用于刺激目标神经的刺激信号。 当沿靶神经的轴突发射动作电位时，在靠近目标神经设置的植入的发射线圈中诱发磁场。 反过来，基于目标神经是否触发动作电位，在与外部刺激装置相关联的接收线圈中产生反馈信号。 基于反馈信号调整刺激信号的刺激信号参数。

公开(公告)号：US20140275554A1

公开(公告)日：2014-09-18

申请号：US14198975

申请日：2014-03-06

申请人： Weijiang Zhang ,  Michael R. Tracey ,  Junning Lee

发明人： Weijiang Zhang ,  Michael R. Tracey ,  Junning Lee

IPC分类号： C07D277/40

CPC分类号： C07D277/40 ,  C07D277/593

摘要： The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.

摘要翻译： 本发明涉及（2Z）-2-（2-氨基-5-氯噻唑-4-基）-2-（3-N-叔丁氧羰基氨基丙氧基亚氨基）乙酸的三乙胺盐的结晶形式。 本发明还涉及制备结晶形式的方法和中间体。 结晶形式可用作制备交联糖肽 - 头孢菌素抗生素的中间体。

公开(公告)号：US07004899B2

公开(公告)日：2006-02-28

申请号：US10183298

申请日：2002-06-27

申请人： Michael R. Tracey

发明人： Michael R. Tracey

IPC分类号： A61F2/00

CPC分类号： A61B1/32 ,  A61B5/202 ,  A61B5/204 ,  A61B5/205 ,  A61B5/208 ,  A61B5/7435 ,  A61B2560/0443

摘要： A portable, self-contained medical diagnostic system is provided for assessing urinary function. The system includes a control device including a processor, a pump device, and a pressure sensor, and a test module removably coupled to the control device, and further including a pressure interface and a tubing assembly defining a first fluid conduit between a first fluid inlet and a first fluid outlet. The pump device is coupled to the first fluid conduit for pumping fluid therethrough. The system also includes an insert member having a first channel therethrough and coupled to the first fluid outlet so that fluid flowing through the first fluid conduit may flow through the first channel. The insert member is dimensioned for insertion into a patient's bladder through the urethral canal. When so inserted, the pressure interface transmits bladder pressure information to the pressure sensor.