摘要:
The invention relates to a process for the direct synthesis of organotin compounds of the formulaR.sub.n SnCl.sub.4-nwhereinn=1-4, and,R=a linear or branched or cycloaliphatic alkyl having 4-18 C atoms,by reacting metallic tin with alkyl chlorides, characterized in that the reaction is carried out in the presence of amines of the general formulaA) R.sup.1.sub.a N [(CH.sub.2 CH.sub.2 O).sub.m CH.sub.2 CH.sub.2 OR.sup.2 ].sub.3-a and/or ammonium chlorides of the formulaB) R.sup.1.sub.b N [(CH.sub.2 CH.sub.2 O).sub.m CH.sub.2 CH.sub.2 OR.sup.2 ].sub.4-b.sup.Clwhereina=0, 1 or 2;b=0, 1, 2 or 3;R.sup.1 =linear or branched or cycloaliphatic alkyl having 2 to 24 C atoms, aryl, alkyl aryl or substituted aryl and, if a=2, or b=2 or 3, the R.sup.1 groups may be the same or different;R.sup.2 =H, linear or branched alkyl having 1 to 20 C. atoms, aryl, substituted aryl or alkyl aryl; andm=1-20.
摘要:
A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要:
Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要:
A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要:
A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof. The method may further include forcing the opening toward the wall of the vascular site after the advancing step and before the moving step.