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    Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
    11.
    发明授权
    Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods 有权
    家用施用器通过相变冷却剂非侵入性地去除皮下富含脂质的细胞的热量，并将装置，系统和方法

    公开(公告)号：US09314368B2

    公开(公告)日：2016-04-19

    申请号：US13013579

    申请日：2011-01-25

    申请人： John W. Allison ,  Mitchell E. Levinson ,  Jesse N. Rosen

    发明人： John W. Allison ,  Mitchell E. Levinson ,  Jesse N. Rosen

    IPC分类号： A61B18/02 ,  A61F7/02 ,  A61F7/00

    CPC分类号： A61F7/02 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61F2007/029 ,  A61F2007/0292

    摘要： Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

    摘要翻译： 家用施用器用于通过相变冷却剂非侵入性地去除皮下富含脂质的细胞的热量，以及相关的装置，系统和方法。 根据特定实施例的装置包括可释放地定位成与人体皮肤热连通的涂抹器和具有冷却剂的冷却剂容器。 该装置还包括传热导管，其可操作地连接到施加器并且容纳与流体与冷却剂接触的隔离的传热流体。 热交换器可操作地联接在冷却剂容器和传热导管之间，以在传热流体和冷却剂之间传递热量，并且流体驱动器可操作地耦合到传热导管，以将传热流体引导到施用器和 热交换器。

    HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATES DEVICES, SYSTEMS AND METHODS
    14.
    发明申请
    HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATES DEVICES, SYSTEMS AND METHODS 有权
    主要应用于通过相变变冷凝器和辅助设备，系统和方法从不利的脂肪细胞中非侵入性去除热量

    公开(公告)号：US20110238050A1

    公开(公告)日：2011-09-29

    申请号：US13013579

    申请日：2011-01-25

    申请人： John W. Allison ,  Mitchell E. Levinson ,  Jesse N. Rosen

    发明人： John W. Allison ,  Mitchell E. Levinson ,  Jesse N. Rosen

    IPC分类号： A61B18/02

    CPC分类号： A61F7/02 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61F2007/029 ,  A61F2007/0292

    摘要： Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

    摘要翻译： 家用施用器用于通过相变冷却剂非侵入性地去除皮下富含脂质的细胞的热量，以及相关的装置，系统和方法。 根据特定实施例的装置包括可释放地定位成与人体皮肤热连通的涂抹器和具有冷却剂的冷却剂容器。 该装置还包括传热导管，其可操作地连接到施加器并且容纳与流体与冷却剂接触的隔离的传热流体。 热交换器可操作地联接在冷却剂容器和传热导管之间，以在传热流体和冷却剂之间传递热量，并且流体驱动器可操作地耦合到传热导管，以将传热流体引导到施用器和 热交换器。

    Sealant applicator and method employing impulse clearing
    17.
    发明授权
    Sealant applicator and method employing impulse clearing 有权
    密封剂涂抹器和采用脉冲清洗的方法

    公开(公告)号：US06926695B2

    公开(公告)日：2005-08-09

    申请号：US10377248

    申请日：2003-02-27

    申请人： Mitchell E. Levinson ,  Gordon Howard Epstein

    发明人： Mitchell E. Levinson ,  Gordon Howard Epstein

    IPC分类号： A61M37/00 ,  A61B17/00 ,  A61M35/00 ,  A61M5/00 ,  B67D5/60

    CPC分类号： A61B17/00491 ,  A61B2017/00495

    摘要： A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.

    摘要翻译： 适用于分配可凝结密封剂的密封剂施加剂，例如混合在施用器中的双组分纤维蛋白密封剂，采用冲洗清除，以从分配通道和混合室（如果存在）中除去残留的凝固或凝结材料。 可以通过手动施加诸如柱塞的清理构件来产生冲击，所述柱塞可以进入分配路径以接合，移除和排出残余物，或者可以产生气体冲击以冲击残余物以产生类似的效果。 具有清除口的清除阀可以通过清除构件的移动来操作，以提供对分配通路的通路。

    Non-newtonian fluid spray applicator and method
    18.
    发明授权
    Non-newtonian fluid spray applicator and method 失效
    非牛顿流体喷雾器及方法

    公开(公告)号：US06432084B1

    公开(公告)日：2002-08-13

    申请号：US09566452

    申请日：2000-05-08

    申请人： Mitchell E. Levinson ,  Gordon H. Epstein

    发明人： Mitchell E. Levinson ,  Gordon H. Epstein

    IPC分类号： A61M100

    CPC分类号： A61M11/02 ,  A61M35/003 ,  A61M2202/0449 ,  B05B1/267 ,  B05B7/066

    摘要： A spray applicator particularly suited to needs of surgeons for dispensing a multi-component fluid, for example fibrin and thrombin components of a tissue adhesive. The spray applicator having a spray nozzle, a liquid dispensing aperture, a spray plate to be impacted by the liquid dispensed and a gas nozzle to provide a stream of carrier gas to carry the dispensed liquid away from the spray plate to form a spray.

    摘要翻译： 特别适用于外科医生用于分配多组分流体（例如组织粘合剂的纤维蛋白和凝血酶组分）的喷雾施用器。 喷雾器具有喷嘴，液体分配孔，待分配的液体冲击的喷射板和气体喷嘴，以提供载气流以将分配的液体远离喷雾板以形成喷雾。

    Secondary alignment fiducials for automatic alignment using machine vision.
    19.
    发明授权
    Secondary alignment fiducials for automatic alignment using machine vision. 失效
    使用机器视觉自动对准的二次对准基准。

    公开(公告)号：US4755053A

    公开(公告)日：1988-07-05

    申请号：US931302

    申请日：1986-11-12

    申请人： Mitchell E. Levinson ,  Thomas T. Frankie

    发明人： Mitchell E. Levinson ,  Thomas T. Frankie

    IPC分类号： G01B11/27 ,  G03F9/00 ,  G01B11/00

    CPC分类号： G03F9/7076 ,  G01B11/27

    摘要： Apparatus and method are provided for reducing processing time for aligning two parts by machine vision. The prior art approach of utilizing a substrate (b 14) with two spaced-apart targets (16a, 16b) and a top-plate (10) with two primary alignment openings (b 12a, 12b) spaced apart the same distance as the targets is improved by providing a set of fiducials (a pair of secondary openings (18a, 18b) or a pair of marks (18'a, 18'b) on the surface) in the top-plate. As a consequence of the novel approach, the vision system is not confused by the similar reflectivities of the target and the top-plate as the substrate and top-plate are brought into contact. Accordingly, alignment may be readily rechecked after assembly.

    摘要翻译： 提供了装置和方法，用于减少通过机器视觉对准两个部件的处理时间。 利用具有两个间隔开的目标（16a，16b）和顶板（10）的基板（b14）的现有技术方法，其具有与目标相同距离间隔开的两个主对准开口（b 12a，12b） 通过在顶板中提供一组基准（表面上的一对次级开口（18a，18b）或一对标记（18'a，18'b））来改进。 作为新方法的结果，视觉系统不会受到与基板和顶板接触的目标和顶板的相似反射率的混淆。 因此，组装后可以容易地重新校准对准。