公开(公告)号：US20140234377A1

公开(公告)日：2014-08-21

申请号：US14166945

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Arimichi OKAZAKI ,  Kyohei MATSUSHITA ,  Daisuke ASARI ,  Takuya SHISHIDO ,  Yoshiki MAEDA ,  Katsuyuki OKUBO ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/572

Abstract: The present invention provides a vaccine composition which comprises a cellular immunity induction promoter universally usable against various antigens in cellular immunity induction by mucosal administration of the antigen and exerts a high cellular immunity inducing effect by mucosal administration. The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.

Abstract translation: 本发明提供一种疫苗组合物，其包含通过粘膜施用抗原而在细胞免疫诱导中抵抗各种抗原通用的细胞免疫诱导启动子，并通过粘膜施用发挥高细胞免疫诱导作用。 本发明提供了用于诱导细胞免疫的粘膜给药用疫苗组合物，其包含：（i）抗原; 和（ii）选自TLR配体，环二核苷酸，辅助肽和免疫调节小分子药物的一种或多种细胞免疫诱导启动子。

公开(公告)号：US20140220063A1

公开(公告)日：2014-08-07

申请号：US14166965

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Daisuke ASARI ,  Katsuyuki OKUBO ,  Takuya SHISHIDO ,  Arimichi OKAZAKI ,  Yoshiki MAEDA ,  Kyohei MATSUSHITA ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K9/00 ,  A61K31/407 ,  A61K31/192 ,  A61K31/405 ,  A61K31/616 ,  A61K31/196 ,  A61K31/415 ,  A61K31/42 ,  A61K31/4035 ,  A61K31/353 ,  A61K31/5575 ,  A61K31/216 ,  A61K31/426 ,  A61K39/29 ,  A61K38/10 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K9/0014 ,  A61K31/192 ,  A61K31/196 ,  A61K31/216 ,  A61K31/353 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/407 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/5575 ,  A61K31/616 ,  A61K38/10 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/572

Abstract: The invention provides a vaccine composition containing an antigen for inducing cellular immunity, comprising at least one first cellular immunity induction promoter.

Abstract translation: 本发明提供含有用于诱导细胞免疫的抗原的疫苗组合物，其包含至少一种第一细胞免疫诱导启动子。

公开(公告)号：US20240024252A1

公开(公告)日：2024-01-25

申请号：US18247612

申请日：2021-10-01

Applicant: National University Corporation Hokkaido University ,  Nitto Denko Corporation

Inventor： Yusuke SATO ,  Hideyoshi HARASHIMA ,  Kazuki HASHIBA ,  Masamitsu TAGUCHI ,  Sachiko SAKAMOTO ,  Takuya SHISHIDO ,  Ayaka OTSU ,  Yoshiki MAEDA

IPC: A61K9/51 ,  C12N15/113 ,  A61K48/00 ,  C12N15/88

CPC classification number: A61K9/5123 ,  C12N15/113 ,  A61K48/0041 ,  C12N15/88 ,  C12N2320/32 ,  C12N2310/14

Abstract: The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).


(R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I)



(R11)(R12)—CH—(CO—O)c—(CH2)v-  (A)



—(CH2)d—N(R3)(R4)  (B)

公开(公告)号：US20140220105A1

公开(公告)日：2014-08-07

申请号：US14166954

申请日：2014-01-29

Applicant: Osaka University ,  NITTO DENKO CORPORATION

Inventor： Yoshiki MAEDA ,  Katsuyuki OKUBO ,  Daisuke ASARI ,  Arimichi OKAZAKI ,  Takuya SHISHIDO ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K39/00 ,  A61K9/70

CPC classification number: A61K39/0011 ,  A61K9/7023 ,  A61K2039/54

Abstract: The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.

Abstract translation: 本发明提供用于诱导细胞免疫的癌症疫苗胶带制剂，其包含：载体，包含设置在载体一侧的粘合剂的粘合剂层，其中所述粘合剂层携带以下组合：（i）WT1肽和/ 或修饰的WT1肽; 和（ii）第一细胞免疫诱导启动子。 胶带制剂可以提供高效率。

公开(公告)号：US20140220059A1

公开(公告)日：2014-08-07

申请号：US14166970

申请日：2014-01-29

Applicant: OSAKA UNIVERSITY ,  NITTO DENKO CORPORATION

Inventor： Daisuke ASARI ,  Kyohei MATSUSHITA ,  Arimichi OKAZAKI ,  Yoshiki MAEDA ,  Katsuyuki OKUBO ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K39/00 ,  A61K9/00

CPC classification number: A61K39/0011 ,  A61K9/0043 ,  A61K9/006 ,  A61K2039/541 ,  A61K2039/542

Abstract: The present invention provides a cancer vaccine composition for mucosal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.

Abstract translation: 本发明提供用于诱导细胞免疫的粘膜给药用癌症疫苗组合物，其包含（i）WT1肽和/或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。 组合物有效地诱导受试者中针对癌症的细胞免疫。