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公开(公告)号：US20180326041A1
公开(公告)日：2018-11-15
申请号：US15777396
申请日：2016-11-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Daisuke ASARI , Eiji KIYOTOH , Kyohei MATSUSHITA , Wenjing LI , Masahiro FUKASAKA , Katsuyuki OKUBO , Mitsuhiko HORI
CPC classification number: A61K39/145 , A61K9/19 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K2039/5252 , A61K2039/542 , A61K2039/55511 , A61K2039/70 , A61P31/16
Abstract: The present invention provides a vaccine pharmaceutical composition for oral administration that enables stable storage of an influenza virus antigen and a method for producing the pharmaceutical composition. Provided is a vaccine pharmaceutical composition for oral administration containing an influenza virus antigen, an excipient, a disaccharide, and an amino acid.
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公开(公告)号：US20140220056A1
公开(公告)日：2014-08-07
申请号：US14166939
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
Abstract translation: 公开了一种用于透皮给药以诱导细胞免疫的疫苗组合物，其包含抗原，其中接受组合物的用于免疫评估的模型动物中的Th1细胞比率为10％以上。
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公开(公告)号：US20230102979A1
公开(公告)日：2023-03-30
申请号：US17909121
申请日：2021-03-03
Applicant: Nitto Denko Corporation
Inventor： Nobuyuki KOZONOI , Yoichi KIGAWA , Wenjing LI , Yugo KASEDA , Hiromi YOKOYAMA , Ryosuke HIRAMOTO
Abstract: An abnormality detecting system includes a first identification unit configured to identify a state of an animal that is a monitoring target in each time range, based on time-series data from a motion sensor placed on a predetermined portion of the animal that is a monitoring target; a first calculation unit configured to calculate a transition probability from the state at a predetermined timing of each time range identified by the first identification unit to a next state; and a determining unit configured to determine that an abnormality of the animal that is a monitoring target is detected when a score calculated based on the transition probability to the next state satisfies a predetermined condition.
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4.发明申请COMPOSITION FOR ACCELERATING PENETRATION THROUGH SKIN, PREPARATION FOR TRANSDERMAL ADMINISTRATION, AND SKIN PATCH PREPARATION 审中-公开通过皮肤加速穿透的组合物，用于超导管理的准备和皮肤配制公开(公告)号：US20170000751A1
公开(公告)日：2017-01-05
申请号：US15113114
申请日：2015-01-28
Applicant: NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Katsuyuki OKUBO , Mitsuhiko HORI
IPC: A61K31/192 , A61K47/22 , A61K9/00 , A61K9/70
CPC classification number: A61K31/192 , A61K9/0014 , A61K9/7053 , A61K31/137 , A61K31/366 , A61K31/437 , A61K31/616 , A61K39/0011 , A61K47/08 , A61K47/22 , A61K2039/54 , A61K2300/00
Abstract: The present invention provides a skin penetration-accelerating composition that eliminates the need for forming a drug into a particle structure and dramatically improves the skin penetration properties of a drug without breaking the skin tissue. The present invention also provides a preparation for transdermal administration containing the skin penetration-accelerating composition and a patch preparation containing the skin penetration-accelerating composition. The present invention provides a skin penetration-accelerating composition containing a flavonoid compound and used for accelerating skin penetration of a drug.
Abstract translation: 本发明提供了一种皮肤渗透促进组合物，其消除了将药物形成颗粒结构的需要，并且显着改善药物的皮肤渗透性而不破坏皮肤组织。 本发明还提供了含有皮肤渗透促进组合物和含有皮肤渗透促进组合物的贴剂的透皮给药制剂。 本发明提供含有类黄酮化合物的皮肤渗透促进组合物，用于促进药物的皮肤渗透。
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公开(公告)号：US20140220079A1
公开(公告)日：2014-08-07
申请号：US14166973
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Daisuke ASARI , Arimichi OKAZAKI , Kyohei MATSUSHITA , Katsuyuki OKUBO , Yoshiki MAEDA , Takuya SHISHIDO , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/39 , A61K39/0011 , A61K2039/541 , A61K2039/542
Abstract: The present invention provides a cancer vaccine composition for mucosal administration comprising (i) a HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于粘膜给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。
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Patent Agency Ranking
公开(公告)号：US20140220100A1
公开(公告)日：2014-08-07
申请号：US14166952
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Katsuyuki OKUBO , Yoshiki MAEDA , Takuya SHISHIDO , Daisuke ASARI , Arimichi OKAZAKI , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K39/00
CPC classification number: A61K39/0005 , A61K39/0011 , A61K2039/54
Abstract: The invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity comprising (i) HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于诱导细胞免疫的透皮给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。
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公开(公告)号：US20140220058A1
公开(公告)日：2014-08-07
申请号：US14166959
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Takuya SHISHIDO , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K9/00 , A61K31/739 , A61K31/4745 , A61K39/00 , A61K38/10
CPC classification number: A61K9/0014 , A61K9/006 , A61K31/4745 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K39/12 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , C12N2770/24234
Abstract: The invention provides a vaccine composition for transdermal or transmucosal administration for inducing cellular immunity, comprising (i) an antigen; and (ii) a pharmacologically acceptable acid or a pharmacologically acceptable salt thereof as a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于诱导细胞免疫的透皮或经粘膜给药的疫苗组合物，其包含（i）抗原; 和（ii）药理学上可接受的酸或其药理学上可接受的盐作为第一细胞免疫诱导启动子。
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公开(公告)号：US20170246287A1
公开(公告)日：2017-08-31
申请号：US15337644
申请日：2016-10-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
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9.发明申请COMPOSITION FOR ACCELERATING PENETRATION THROUGH SKIN, PREPARATION FOR TRANSDERMAL ADMINISTRATION, AND SKIN PATCH PREPARATION 审中-公开通过皮肤加速穿透的组合物，用于超导管理的准备和皮肤配制公开(公告)号：US20170007703A1
公开(公告)日：2017-01-12
申请号：US15113275
申请日：2015-01-28
Applicant: NITTO DENKO CORPORATION
Inventor： Kyohei MATSUSHITA , Yoshiki MAEDA , Wenjing LI , Katsuyuki OKUBO , Mitsuhiko HORI
IPC: A61K47/22 , A61K31/616 , A61K38/45 , A61K31/192 , A61K9/00 , A61K9/70
CPC classification number: A61K47/22 , A61K9/0014 , A61K9/7053 , A61K31/192 , A61K31/352 , A61K31/366 , A61K31/616 , A61K38/45 , A61K47/08 , C12Y207/10001 , A61K2300/00
Abstract: The present invention provides a skin penetration-accelerating composition that eliminates the need for forming a drug into a particle structure and dramatically improves the skin penetration properties of a drug without breaking the skin tissue. The present invention also provides a preparation for transdermal administration containing the skin penetration-accelerating composition and a patch preparation containing the skin penetration-accelerating composition. The present invention provides a skin penetration-accelerating composition containing a flavonoid compound and a surfactant and used for accelerating skin penetration of a drug.
Abstract translation: 本发明提供了一种皮肤渗透促进组合物，其消除了将药物形成颗粒结构的需要，并且显着改善药物的皮肤渗透性而不破坏皮肤组织。 本发明还提供了含有皮肤渗透促进组合物和含有皮肤渗透促进组合物的贴剂的透皮给药制剂。 本发明提供含有类黄酮化合物和表面活性剂的皮肤渗透促进组合物，用于加速药物的皮肤渗透。
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公开(公告)号：US20140234377A1
公开(公告)日：2014-08-21
申请号：US14166945
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Arimichi OKAZAKI , Kyohei MATSUSHITA , Daisuke ASARI , Takuya SHISHIDO , Yoshiki MAEDA , Katsuyuki OKUBO , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K39/00
CPC classification number: A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55566 , A61K2039/55583 , A61K2039/572
Abstract: The present invention provides a vaccine composition which comprises a cellular immunity induction promoter universally usable against various antigens in cellular immunity induction by mucosal administration of the antigen and exerts a high cellular immunity inducing effect by mucosal administration. The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.
Abstract translation: 本发明提供一种疫苗组合物，其包含通过粘膜施用抗原而在细胞免疫诱导中抵抗各种抗原通用的细胞免疫诱导启动子，并通过粘膜施用发挥高细胞免疫诱导作用。 本发明提供了用于诱导细胞免疫的粘膜给药用疫苗组合物，其包含：（i）抗原; 和（ii）选自TLR配体，环二核苷酸，辅助肽和免疫调节小分子药物的一种或多种细胞免疫诱导启动子。
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