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公开(公告)号：US20140220056A1
公开(公告)日：2014-08-07
申请号：US14166939
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
Abstract translation: 公开了一种用于透皮给药以诱导细胞免疫的疫苗组合物，其包含抗原，其中接受组合物的用于免疫评估的模型动物中的Th1细胞比率为10％以上。
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2.发明申请公开(公告)号：US20140220055A1
公开(公告)日：2014-08-07
申请号：US14166932
申请日：2014-01-29
Applicant: OSAKA UNIVERSITY , NITTO DENKO CORPORATION
Inventor： Katsuyuki OKUBO , Yoshiki MAEDA , Arimichi OKAZAKI , Daisuke ASARI , Takuya SHISHIDO , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K9/0014 , A61K38/10 , A61K39/0011 , A61K2039/54
Abstract: The present invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
Abstract translation: 本发明提供一种用于诱导细胞免疫的透皮给药的癌症疫苗组合物，其包含（i）WT1肽和/或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。 组合物有效地诱导受试者中针对癌症的细胞免疫。
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3.发明申请TAPE PREPARATION OF WT1 PEPTIDE CANCER VACCINE FOR TRANSDERMAL ADMINISTRATION 审中-公开WT1肽制剂用于转导管理的胶带制备公开(公告)号：US20140220105A1
公开(公告)日：2014-08-07
申请号：US14166954
申请日：2014-01-29
Applicant: Osaka University , NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Takuya SHISHIDO , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/0011 , A61K9/7023 , A61K2039/54
Abstract: The present invention provides a cancer vaccine tape preparation for inducing cellular immunity, comprising: a support, an adhesive layer comprising an adhesive disposed on one side of the support, wherein the adhesive layer carries a combination of: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter. The tape preparation can provides high efficacy.
Abstract translation: 本发明提供用于诱导细胞免疫的癌症疫苗胶带制剂，其包含：载体，包含设置在载体一侧的粘合剂的粘合剂层，其中所述粘合剂层携带以下组合：（i）WT1肽和/ 或修饰的WT1肽; 和（ii）第一细胞免疫诱导启动子。 胶带制剂可以提供高效率。
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公开(公告)号：US20140220059A1
公开(公告)日：2014-08-07
申请号：US14166970
申请日：2014-01-29
Applicant: OSAKA UNIVERSITY , NITTO DENKO CORPORATION
Inventor： Daisuke ASARI , Kyohei MATSUSHITA , Arimichi OKAZAKI , Yoshiki MAEDA , Katsuyuki OKUBO , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/0011 , A61K9/0043 , A61K9/006 , A61K2039/541 , A61K2039/542
Abstract: The present invention provides a cancer vaccine composition for mucosal administration for inducing cellular immunity, comprising (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a cellular immunity induction promoter. The composition efficiently induces cellular immunity against a cancer in a subject.
Abstract translation: 本发明提供用于诱导细胞免疫的粘膜给药用癌症疫苗组合物，其包含（i）WT1肽和/或修饰的WT1肽; 和（ii）细胞免疫诱导启动子。 组合物有效地诱导受试者中针对癌症的细胞免疫。
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公开(公告)号：US20140220100A1
公开(公告)日：2014-08-07
申请号：US14166952
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Katsuyuki OKUBO , Yoshiki MAEDA , Takuya SHISHIDO , Daisuke ASARI , Arimichi OKAZAKI , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K39/00
CPC classification number: A61K39/0005 , A61K39/0011 , A61K2039/54
Abstract: The invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity comprising (i) HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于诱导细胞免疫的透皮给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。
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Patent Agency Ranking
公开(公告)号：US20140220058A1
公开(公告)日：2014-08-07
申请号：US14166959
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Yoshiki MAEDA , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Takuya SHISHIDO , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K9/00 , A61K31/739 , A61K31/4745 , A61K39/00 , A61K38/10
CPC classification number: A61K9/0014 , A61K9/006 , A61K31/4745 , A61K31/739 , A61K38/10 , A61K39/0011 , A61K39/12 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , C12N2770/24234
Abstract: The invention provides a vaccine composition for transdermal or transmucosal administration for inducing cellular immunity, comprising (i) an antigen; and (ii) a pharmacologically acceptable acid or a pharmacologically acceptable salt thereof as a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于诱导细胞免疫的透皮或经粘膜给药的疫苗组合物，其包含（i）抗原; 和（ii）药理学上可接受的酸或其药理学上可接受的盐作为第一细胞免疫诱导启动子。
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公开(公告)号：US20170246287A1
公开(公告)日：2017-08-31
申请号：US15337644
申请日：2016-10-28
Applicant: NITTO DENKO CORPORATION
Inventor： Takuya SHISHIDO , Katsuyuki OKUBO , Daisuke ASARI , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/12 , A61K9/0014 , A61K9/06 , A61K9/7084 , A61K39/0011 , A61K39/39 , A61K47/32 , A61K47/34 , A61K2039/54 , A61K2039/55583
Abstract: Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that received the composition is 10% or more.
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公开(公告)号：US20140234377A1
公开(公告)日：2014-08-21
申请号：US14166945
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Arimichi OKAZAKI , Kyohei MATSUSHITA , Daisuke ASARI , Takuya SHISHIDO , Yoshiki MAEDA , Katsuyuki OKUBO , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K39/00
CPC classification number: A61K39/0011 , A61K39/39 , A61K2039/542 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55566 , A61K2039/55583 , A61K2039/572
Abstract: The present invention provides a vaccine composition which comprises a cellular immunity induction promoter universally usable against various antigens in cellular immunity induction by mucosal administration of the antigen and exerts a high cellular immunity inducing effect by mucosal administration. The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.
Abstract translation: 本发明提供一种疫苗组合物，其包含通过粘膜施用抗原而在细胞免疫诱导中抵抗各种抗原通用的细胞免疫诱导启动子，并通过粘膜施用发挥高细胞免疫诱导作用。 本发明提供了用于诱导细胞免疫的粘膜给药用疫苗组合物，其包含：（i）抗原; 和（ii）选自TLR配体，环二核苷酸，辅助肽和免疫调节小分子药物的一种或多种细胞免疫诱导启动子。
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公开(公告)号：US20140220063A1
公开(公告)日：2014-08-07
申请号：US14166965
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Daisuke ASARI , Katsuyuki OKUBO , Takuya SHISHIDO , Arimichi OKAZAKI , Yoshiki MAEDA , Kyohei MATSUSHITA , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
IPC: A61K9/00 , A61K31/407 , A61K31/192 , A61K31/405 , A61K31/616 , A61K31/196 , A61K31/415 , A61K31/42 , A61K31/4035 , A61K31/353 , A61K31/5575 , A61K31/216 , A61K31/426 , A61K39/29 , A61K38/10 , A61K39/39 , A61K39/00
CPC classification number: A61K9/0014 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/353 , A61K31/4035 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/5575 , A61K31/616 , A61K38/10 , A61K39/0011 , A61K39/39 , A61K2039/54 , A61K2039/572
Abstract: The invention provides a vaccine composition containing an antigen for inducing cellular immunity, comprising at least one first cellular immunity induction promoter.
Abstract translation: 本发明提供含有用于诱导细胞免疫的抗原的疫苗组合物，其包含至少一种第一细胞免疫诱导启动子。
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公开(公告)号：US20140220079A1
公开(公告)日：2014-08-07
申请号：US14166973
申请日：2014-01-29
Applicant: NITTO DENKO CORPORATION
Inventor： Daisuke ASARI , Arimichi OKAZAKI , Kyohei MATSUSHITA , Katsuyuki OKUBO , Yoshiki MAEDA , Takuya SHISHIDO , Wenjing LI , Mitsuhiko HORI , Haruo SUGIYAMA
CPC classification number: A61K39/39 , A61K39/0011 , A61K2039/541 , A61K2039/542
Abstract: The present invention provides a cancer vaccine composition for mucosal administration comprising (i) a HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.
Abstract translation: 本发明提供了用于粘膜给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。
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