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    ALLERGY VACCINE COMPOSITION
    4.
    发明申请
    ALLERGY VACCINE COMPOSITION 审中-公开

    公开(公告)号：US20180147235A1

    公开(公告)日：2018-05-31

    申请号：US15570851

    申请日：2016-04-28

    Applicant: NITTO DENKO CORPORATION

    Inventor： Kyohei MATSUSHITA ,  Masahiro FUKASAKA ,  Takuya SHISHIDO ,  Daisuke ASARI ,  Katsuyuki OKUBO ,  Mitsuhiko HORI

    IPC: A61K31/739 ,  A61K39/35 ,  A61K39/02 ,  A61P17/04 ,  A61P37/02 ,  A61P37/08 ,  A61P11/06 ,  A61P11/02

    Abstract: The present invention provides an allergy vaccine composition that is useful as a prophylactic or therapeutic agent for an allergic disease and can safely and effectively induce immune tolerance. The vaccine composition is to be administered to a human or animal with an allergic disease for the prevention or treatment of the allergic disease. The vaccine composition contains: an immunomodulator which is a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt of the lipopolysaccharide; and at least one allergen.

    MUCOSAL VACCINE COMPOSITION
    5.
    发明申请
    MUCOSAL VACCINE COMPOSITION 审中-公开
    胶原蛋白组合物

    公开(公告)号：US20160193327A1

    公开(公告)日：2016-07-07

    申请号：US14917084

    申请日：2014-10-02

    Applicant: NITTO DENKO CORPORATION

    Inventor： Masahiro FUKASAKA ,  Mitsuhiko HORI ,  Katsuyuki OKUBO ,  Daisuke ASARI ,  Arimichi OKAZAKI ,  Eiji KIYOTOH ,  Kyohei MATSUSHITA

    IPC: A61K39/385 ,  A61K39/09 ,  A61K39/12 ,  A61K39/15 ,  A61K39/29 ,  A61K39/165 ,  A61K39/155 ,  A61K39/20 ,  A61K39/08 ,  A61K39/25 ,  A61K39/04 ,  A61K39/205 ,  A61K39/13 ,  C12N7/00 ,  A61K47/48 ,  A61K39/145

    CPC classification number: A61K39/385 ,  A61K9/006 ,  A61K39/04 ,  A61K39/08 ,  A61K39/092 ,  A61K39/12 ,  A61K39/13 ,  A61K39/145 ,  A61K39/15 ,  A61K39/155 ,  A61K39/165 ,  A61K39/20 ,  A61K39/205 ,  A61K39/25 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/541 ,  A61K2039/55572 ,  A61K2039/575 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/20034 ,  C12N2720/12334 ,  C12N2730/10134 ,  C12N2760/16034 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2760/20134 ,  C12N2770/24134 ,  C12N2770/32434 ,  C12N2770/32634 ,  C12N2770/36234

    Abstract: The present invention aims at providing a mucosal vaccine composition that can be administered to an intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, or rectal mucous membrane, that is useful as a prophylactic or therapeutic agent for infectious diseases or cancers, and is capable of safely and effectively inducing the systemic immune response and mucosal immune response. The present invention provides a mucosal vaccine composition to be administered to at least one mucous membrane selected from the group consisting of a human or animal intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, and rectal mucous membrane, containing: at least one antigen; and as an adjuvant, a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.

    Abstract translation: 本发明的目的是提供一种粘膜疫苗组合物，其可以施用于口内粘膜，眼粘膜，耳粘膜，生殖器粘膜，咽粘膜，呼吸道粘膜，支气管粘膜，肺粘膜，胃 粘膜，肠粘膜或直肠粘膜，其可用作感染性疾病或癌症的预防或治疗剂，并且能够安全有效地诱导全身免疫应答和粘膜免疫应答。 本发明提供一种粘膜疫苗组合物，其用于至少一种选自人或动物口腔内粘膜，眼粘膜，耳粘膜，生殖器粘膜，咽粘膜，呼吸道粘液的粘膜 膜，支气管粘膜，肺粘膜，胃粘膜，肠粘膜和直肠粘膜，含有至少一种抗原; 并且作为佐剂，衍生自选自沙雷氏菌属（Salratia），莱克氏菌属（Leclercia），R，属（Rahnella），酸性d螨属（Acidicaldus），酸性，螨属（Acidical il ium，，，era era era era era era era，，，，，，，，Acid Acid Acid Acid as as，As As As ia ia ia ia ia C occus occus occus occus occus，，，ia ia，，，，，，，，，，， （Leahibacter），红球菌属（Myocosococcus），梭状芽孢杆菌属，微球菌属，黄杆菌属，泛菌属，醋杆菌属，发酵单胞菌属，黄单胞菌属，蓝假丝酵母属，蓝假丝酵母属，蓝假丝酵母属， 和肠杆菌属或其盐。

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