公开(公告)号：US09011430B2

公开(公告)日：2015-04-21

申请号：US13503598

申请日：2010-11-04

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B18/18 ,  A61B18/04 ,  A61B17/22 ,  A61B18/14 ,  A61B18/08 ,  A61B18/24 ,  A61B19/00 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61F2/01

CPC classification number: A61B17/22 ,  A61B17/2202 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/245 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2090/3788 ,  A61F2/013 ,  C08L2201/12

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localized ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract translation: 提供了一种适于重塑至少部分被块体封闭的中空容器的内表面的装置和方法。 所述装置包括具有远端和近端的细长主体，所述远端包括位于所述主体的远端的尖端部分，以及位于所述远端内的所述尖端部分的近侧的至少一个加热元件。 所述至少一个加热元件被配置为在远端比近端更大的尺寸，从而朝向远端逐渐变细。 此外，至少一个加热元件被布置成使得其可以从装置的主体向外展开，并且这样对中空容器施加膨胀力。 所述至少一个加热元件能够输送足够的能量来重建内表面，并且如果需要引起中空容器的局部消融，而不引起中空容器的封闭。

公开(公告)号：US20130211176A1

公开(公告)日：2013-08-15

申请号：US13806073

申请日：2011-06-24

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B18/14 ,  A61N5/10 ,  A61N7/00

CPC classification number: A61B18/1492 ,  A61B17/3478 ,  A61B18/1477 ,  A61B2017/00296 ,  A61B2017/320069 ,  A61B2018/00613 ,  A61B2018/00821 ,  A61B2018/1425 ,  A61B2018/1869 ,  A61B2090/3784 ,  A61B2090/3925 ,  A61B2218/001 ,  A61N5/1001 ,  A61N7/00 ,  A61N2007/025

Abstract: Apparatus and methods suitable for causing tissue ablation at a specified therapeutic site in the body of a patient. The apparatus comprises an ablation device having a distal end and a proximal end and a central lumen extending along its length, the distal end comprising at least one energy delivery element suitable for causing tissue ablation. A penetrating member having a distal end and a proximal end, the distal end comprising a sharp tip suitable for piercing tissue and creating a channel for the device in the tissue, is coaxially positioned within the central lumen of the ablation device and is capable of being advanced distally out of the central lumen of the device and retracted back to within the central lumen of the device. The apparatus may further comprise an endoscope for delivery of the device to the site of treatment.

Abstract translation: 适合于在患者体内的特定治疗部位引起组织消融的装置和方法。 该装置包括具有远端和近端以及沿其长度延伸的中心腔的消融装置，远端包括适合于引起组织消融的至少一个能量输送元件。 具有远端和近端的穿透构件，所述远端包括适于刺穿组织并且为所述组织中的装置产生通道的尖端，其同轴地位于所述消融装置的中心腔内，并且能够被 从装置的中央腔向前远端延伸并缩回到装置的中央腔内。 该装置还可以包括用于将装置输送到治疗部位的内窥镜。

公开(公告)号：US20100049191A1

公开(公告)日：2010-02-25

申请号：US12374627

申请日：2007-07-23

Applicant: Nagy Habib ,  Andrew Pacey

Inventor： Nagy Habib ,  Andrew Pacey

IPC: A61B18/14 ,  A61B1/00

CPC classification number: A61B18/1492 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/1425 ,  A61B2018/144 ,  A61B2018/1475

Abstract: A flexible RF device (1) can be deployed through a flexible endoscope. An electrode structure has a central electrode (12) and outer electrode (11). Flexible electrodes (30), circular electrodes (51, 53) and circular loop assemblies (55, 56) with different diameters are also disclosed, as well a tweezer electrodes (41) with pads (43) for increasing contact area. Retractable electrodes (100) are also disclosed.

Abstract translation: 柔性射频装置（1）可以通过柔性内窥镜部署。 电极结构具有中心电极（12）和外电极（11）。 还公开了具有不同直径的柔性电极（30），圆形电极（51,53）和圆环组件（55,56），以及具有用于增加接触面积的衬垫（43）的镊子电极（41）。 还公开了伸缩电极（100）。

公开(公告)号：US20050171534A1

公开(公告)日：2005-08-04

申请号：US10953989

申请日：2004-09-29

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B18/14

CPC classification number: A61B18/1477 ,  A61B2018/0016 ,  A61B2018/143

Abstract: A surgical organ resection device comprising a plurality of elongate electrodes for insertion into organ tissue, the electrodes being capable of operating in a bipolar manner, and an input for receiving a drive signal for driving the electrode, the elongate electrodes being arranged in a two-dimensional array and/or the device being arranged such that, in use, subsets of the elongate electrodes are driven in turn.

Abstract translation: 一种手术器官切除装置，包括用于插入器官组织的多个细长电极，电极能够以双极方式操作，以及用于接收用于驱动电极的驱动信号的输入端， 尺寸阵列和/或设备被布置成使得在使用中，细长电极的子集依次被驱动。

公开(公告)号：US20120232326A1

公开(公告)日：2012-09-13

申请号：US13503598

申请日：2010-11-04

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B18/00 ,  A61N5/10 ,  A61B18/18 ,  A61B18/04 ,  A61B18/12

CPC classification number: A61B17/22 ,  A61B17/2202 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/245 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2090/3788 ,  A61F2/013 ,  C08L2201/12

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localised ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract translation: 提供了一种适于重塑至少部分被块体封闭的中空容器的内表面的装置和方法。 所述装置包括具有远端和近端的细长主体，所述远端包括位于所述主体的远端的尖端部分，以及位于所述远端内的所述尖端部分的近侧的至少一个加热元件。 所述至少一个加热元件被配置为在远端比近端更大的尺寸，从而朝向远端逐渐变细。 此外，至少一个加热元件被布置成使得其可以从装置的主体向外展开，并且这样对中空容器施加膨胀力。 所述至少一个加热元件能够输送足够的能量来重建内表面，并且如果需要引起中空容器的局部消融，而不引起中空容器的封闭。

公开(公告)号：US20110208181A1

公开(公告)日：2011-08-25

申请号：US13019911

申请日：2011-02-02

Applicant: Nagy Habib

Inventor： Nagy Habib

IPC: A61B17/22 ,  A61B18/18

CPC classification number: A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22001 ,  A61B2017/22038 ,  A61B2018/00422 ,  A61B2018/00702 ,  A61B2018/00875

Abstract: A method for maintaining patency in a duct or hollow vessel located within the body of a patient is described wherein the duct includes one or more obstructions. The method comprises the steps of introducing a device into the duct, the device comprising a catheter having a distal and a proximal end, wherein the distal end includes a distal tip portion and wherein the distal tip portion comprises at least one energy delivery member; locating the device within the duct at a position proximal to the obstruction; delivering energy to the duct and any surrounding tissue via the at least one energy delivery member for a specified time period, so that the obstruction is removed from the duct; and withdrawing the device from the duct. It is optional to subsequently place a device such as a stent at the therapy site in order to further maintain long term patency of the duct. It is also optional to apply a dilation force to the duct or hollow vessel after the energy delivery phase. Systems are also described for performing the methods of the disclosure.

Abstract translation: 描述了一种用于在位于患者体内的管道或中空容器中保持通畅的方法，其中管道包括一个或多个障碍物。 该方法包括以下步骤：将装置引入管道，该装置包括具有远端和近端的导管，其中远端包括远侧末端部分，并且其中远侧末端部分包括至少一个能量传递构件; 将设备定位在管道内靠近障碍物的位置; 经由所述至少一个能量传递构件将管道和任何周围组织的能量输送达指定的时间段，使得所述障碍物从所述管道移除; 并从设备中取出设备。 随后将诸如支架的装置放置在治疗部位以便进一步维持管道的长期通畅性是可选的。 在能量输送阶段之后，也可以在管道或中空容器上施加扩张力。 还描述了用于执行本公开的方法的系统。

公开(公告)号：US20070105848A1

公开(公告)日：2007-05-10

申请号：US11534300

申请日：2006-09-22

Applicant: Christopher Wood ,  Nagy Habib

Inventor： Christopher Wood ,  Nagy Habib

IPC: A61K31/5415 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/185 ,  A61K31/29

CPC classification number: A61K45/06 ,  A61K9/2846 ,  A61K9/2866 ,  A61K31/185 ,  A61K31/29 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/5415 ,  A61K41/0057 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/491 ,  A61K2300/00 ,  A61K41/00

Abstract: A method for using thiazine dyes, especially methylene blue, alone or in combination with low levels of light, to treat parasitic diseases is described. Examples of useful thiazine dyes are methylene blue, azure A, azure C, toluidine, and thionine. The preferred dye is methylene blue, administered orally twice a day. Since methylene blue absorbs in the red wavelengths, i.e., approximately 670 nm, which penetrates tissue much better than other lower wavelengths, light penetrating the skin to the capillaries at the surface can be used to enhance the activity of the dye. The thiazine dye can be provided in combination with other known antibiotics, anti-inflammatories, anti-parasitics, antifungals, and antivirals.

Abstract translation: 描述了使用噻嗪染料，特别是亚甲蓝单独或与低水平的光结合来治疗寄生虫病的方法。 有用的噻嗪染料的实例是亚甲基蓝，天蓝A，天蓝C，甲苯胺和硫
素。 优选的染料是亚甲基蓝，每天口服两次。 由于亚甲基蓝以相对于其它较低波长穿透组织的红色波长（即大约670nm）吸收，所以可以使用将表皮穿透到毛细管的光线来提高染料的活性。 噻嗪染料可以与其他已知的抗生素，抗炎剂，抗寄生虫，抗真菌剂和抗病毒药物组合提供。