公开(公告)号：US20120089047A1

公开(公告)日：2012-04-12

申请号：US13204504

申请日：2011-08-05

申请人： Eric Ryba ,  Naomi Buckley ,  Benjamin J. Clark ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Roman Turovskiy ,  Lana Wooley ,  Denise Zarins ,  Mark Gelfand ,  Mark Leung

发明人： Eric Ryba ,  Naomi Buckley ,  Benjamin J. Clark ,  Danny Donovan ,  Luke Hughes ,  Brian Kelly ,  Gwenda McMullin ,  Karun D. Naga ,  Stephen Nash ,  Roman Turovskiy ,  Lana Wooley ,  Denise Zarins ,  Mark Gelfand ,  Mark Leung

IPC分类号： A61B18/02 ,  A61B5/05 ,  A61B5/00

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

摘要： Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

摘要翻译： 本文公开了通过血管内通路低血压调节肾丛神经结构的导管装置，系统和方法。 本申请的一个方面，例如，涉及包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造适于通过血管内途径将低温涂敷器递送至肾动脉。 低温肾神经调节可以通过应用低温温度来实现，以调节有助于肾功能的神经纤维，或者供给或灌注神经纤维的血管结构。

公开(公告)号：US20140316398A1

公开(公告)日：2014-10-23

申请号：US14114566

申请日：2012-04-27

申请人： Brian Kelly ,  Gary Kelly ,  Barry Mullins ,  Fiachra Sweeney

发明人： Brian Kelly ,  Gary Kelly ,  Barry Mullins ,  Fiachra Sweeney

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/0418 ,  A61B2090/0463

摘要： Systems and methods related to selective heating of cryogenic balloons for targeted cryogenic neuromodulation are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having a proximal portion and a distal portion. The shaft can be configured to locate the distal portion in a vessel. The cryotherapeutic device can further include a cryoballoon extending from the distal portion and a plurality of heating elements arranged about the cryoballoon. The plurality of heating elements can be individually controlled to selectively deliver heat to tissue of a wall of the vessel proximate the outer surface of the cryoballoon.

摘要翻译： 本文公开了用于靶向低温神经调节的低温气球的选择性加热相关的系统和方法。 根据本技术的特定实施例构造的冷冻治疗装置可以包括具有近端部分和远端部分的细长轴。 轴可以构造成将远端部分定位在血管中。 所述冷冻治疗装置还可以包括从所述远侧部分延伸的低温球和围绕所述低温球布置的多个加热元件。 可以单独地控制多个加热元件以选择性地将热量传递到靠近冷冻小球的外表面的血管壁的组织。

公开(公告)号：US20150126986A1

公开(公告)日：2015-05-07

申请号：US14114345

申请日：2012-04-25

申请人： Brian Kelly ,  John Kelly ,  Gary Kelly ,  Barry Mullins

发明人： Brian Kelly ,  John Kelly ,  Gary Kelly ,  Barry Mullins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/00244 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212

摘要： Embodiments related to cryogenically ablating a portion of the inner surface of a vessel by constraining a cryoballoon using various apparatuses and methods are disclosed. For example, a catheter can include a cryoballoon for ablation of the vessel wall and a constraining element disposed substantially in parallel with the cryoballoon to deflect or offset a portion of the cryoballoon away from non-target tissue of the vessel wall and prevent ablation of the non-target tissue. Partial circumferential, non-continuous, or helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The constraining element may be, for example, a second inflatable balloon or one or more self-expanding prongs.

摘要翻译： 公开了通过使用各种装置和方法约束低温球来低温地烧蚀容器的内表面的一部分的实施例。 例如，导管可以包括用于消融血管壁的低温球和约束元件，该约束元件基本上与低血球平行地设置，以使冷冻球的一部分远离血管壁的非目标组织偏转或偏移，并防止 非目标组织。 部分圆周，非连续或螺旋消融可有效治疗各种肾，心肾和其他疾病，包括但不限于高血压，心力衰竭，肾脏疾病，肾衰竭，对比肾病，心律失常和心肌 梗死。 约束元件可以是例如第二可膨胀气囊或一个或多个自膨胀尖头。

公开(公告)号：US20110251676A1

公开(公告)日：2011-10-13

申请号：US12758272

申请日：2010-04-12

申请人： Fiachra Sweeney ,  Paula McDonnell ,  Brian Kelly ,  Patrick Duane ,  John MacNamara ,  Frank Harewood

发明人： Fiachra Sweeney ,  Paula McDonnell ,  Brian Kelly ,  Patrick Duane ,  John MacNamara ,  Frank Harewood

IPC分类号： A61F2/84

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2427

摘要： Apparatus and methods are disclosed for controlling deployment of a self-expanding support structure of a prosthetic valve that flares in a proximal direction upon implantation in vivo. A tubular delivery sheath having a side opening that proximally extends within a side wall thereof is used to deploy the prosthetic valve with the self-expanding support structure in a controlled manner. The prosthetic valve is distally advanced within a lumen of the delivery sheath with the self-expanding support structure held in a compressed delivery configuration within the delivery sheath lumen. The self-expanding support structure of the prosthetic valve is aligned with the side opening of the delivery sheath and the prosthetic valve is rotated relative to the delivery sheath whereby the self-expanding support structure is laterally released from the delivery sheath lumen through the side opening to gradually transition from the compressed delivery configuration to a flared deployed configuration.

摘要翻译： 公开了用于控制在体内植入时在近端方向上展开的假体瓣膜的自扩张支撑结构的展开的装置和方法。 使用具有在其侧壁内近侧延伸的侧开口的管状输送护套以受控的方式展开具有自膨胀支撑结构的人造瓣膜。 假体瓣膜在输送鞘的内腔中向远侧推进，其中自扩张支撑结构保持在输送鞘腔内的压缩输送构型。 假体瓣膜的自膨胀支撑结构与输送鞘的侧开口对齐，并且假体瓣相对于输送鞘旋转，由此自扩张支撑结构通过侧开口横向地从输送鞘腔释放 逐渐从压缩传送配置转换到扩展部署配置。

公开(公告)号：US08486014B2

公开(公告)日：2013-07-16

申请号：US13072689

申请日：2011-03-26

申请人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

发明人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

IPC分类号： A61M25/00

CPC分类号： A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1084 ,  A61M2025/1097

摘要： A balloon dilatation catheter for use in a valvuloplasty procedure includes a catheter shaft and a spiral perfusion balloon mounted thereon. The perfusion balloon is formed from an inflatable tube that is in fluid communication with a catheter shaft inflation lumen. The inflatable tube is coiled into a series of windings that in an inflated configuration form a cylindrical or hourglass profile. In the inflated configuration, inner surfaces of the coiled windings of the inflatable tube define a perfusion lumen to allow blood flow through the perfusion balloon. Adjacent windings may be secured together with a flexible adhesive and/or a support weave formed from one or more filaments of material that criss-crosses between the adjacent windings along substantially the entire length of the spiral perfusion balloon.

摘要翻译： 用于瓣膜成形术的球囊扩张导管包括安装在其上的导管轴和螺旋灌注球囊。 灌注气球由与导管轴膨胀腔流体连通的可充气管形成。 可膨胀管被卷成一系列绕组，其以膨胀构型形成圆柱形或沙漏型。 在充气构造中，可膨胀管的线圈绕组的内表面限定了灌注腔，以允许血液流过灌注球囊。 相邻绕组可以用柔性粘合剂和/或由沿着螺旋形灌注气球的整个长度在相邻绕组之间交叉的一个或多个材料丝构成的支撑织物固定在一起。

公开(公告)号：US20120245520A1

公开(公告)日：2012-09-27

申请号：US13072689

申请日：2011-03-26

申请人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

发明人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

IPC分类号： A61M25/10

CPC分类号： A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1084 ,  A61M2025/1097

摘要： A balloon dilatation catheter for use in a valvuloplasty procedure includes a catheter shaft and a spiral perfusion balloon mounted thereon. The perfusion balloon is formed from an inflatable tube that is in fluid communication with a catheter shaft inflation lumen. The inflatable tube is coiled into a series of windings that in an inflated configuration form a cylindrical or hourglass profile. In the inflated configuration, inner surfaces of the coiled windings of the inflatable tube define a perfusion lumen to allow blood flow through the perfusion balloon. Adjacent windings may be secured together with a flexible adhesive and/or a support weave formed from one or more filaments of material that criss-crosses between the adjacent windings along substantially the entire length of the spiral perfusion balloon.

摘要翻译： 用于瓣膜成形术的球囊扩张导管包括安装在其上的导管轴和螺旋灌注球囊。 灌注气球由与导管轴膨胀腔流体连通的可充气管形成。 可膨胀管被卷成一系列绕组，其以膨胀构型形成圆柱形或沙漏型。 在充气构造中，可膨胀管的线圈绕组的内表面限定了灌注腔，以允许血液流过灌注球囊。 相邻绕组可以用柔性粘合剂和/或由沿着螺旋形灌注气球的整个长度在相邻绕组之间交叉的一个或多个材料丝构成的支撑织物固定在一起。

公开(公告)号：US09162367B2

公开(公告)日：2015-10-20

申请号：US13572272

申请日：2012-08-10

申请人： Ted Williams ,  Brian Kelly

发明人： Ted Williams ,  Brian Kelly

IPC分类号： B27B27/08 ,  B27B31/06

CPC分类号： B27B27/08 ,  B27B31/06 ,  Y10T83/04 ,  Y10T83/728

摘要： A system and a method of using the system for reproducibly cutting a cove using a table saw are presented. The system comprises a first fence assembly and a fixturing means, where the fence assembly is rotatably affixed to the fixturing means, wherein the fixturing means can be releasably secured to the table of the table saw. The method comprises providing a blank molding, a table saw having a table and saw blade, and the cove system and releasably affixing the cove system to the table. The method further comprises setting a fence angle using the first fence assembly and setting a fence depth by adjusting the position of the fixturing means with respect to the table. The method finally comprises feeding the blank molding over the saw blade thereby cutting a cove in the blank molding.

摘要翻译： 提出了一种使用该系统和使用台锯可重复切割海湾的系统的方法。 所述系统包括第一围栏组件和固定装置，其中所述围栏组件可旋转地固定到所述固定装置，其中所述夹持装置可释放地固定到所述台锯台上。 该方法包括提供坯料模制品，具有桌子和锯片的台锯以及小湾系统，并将椰子系统可释放地固定在桌子上。 该方法还包括使用第一围栏组件设置围栏角度，并通过调整夹具装置相对于工作台的位置来设定挡板深度。 该方法最终包括将坯料模制物在锯片上进给，从而在坯料模制件中切割一个凸缘。

公开(公告)号：US20130122516A1

公开(公告)日：2013-05-16

申请号：US13805983

申请日：2011-07-01

申请人： Rui Hong ,  Hong Wang ,  Mark Lefever ,  Jan Froehlich ,  Christopher Bieniarz ,  Brian Kelly ,  Phillip Miller

发明人： Rui Hong ,  Hong Wang ,  Mark Lefever ,  Jan Froehlich ,  Christopher Bieniarz ,  Brian Kelly ,  Phillip Miller

IPC分类号： G01N27/62

CPC分类号： G01N33/6848 ,  G01N27/62

摘要： Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.

摘要翻译： 本文公开的具体公开的实施方案涉及使用一种或多种各种质量标签，其可以通过直接或间接的酶催化转化特异性沉积在靶上，以提供用于鉴定组织样品中靶标的方法。 质量标签可以用稳定同位素标记，以产生具有相同化学结构但质量不同的质量标签。 使用质谱检测和/或定量通过电离质量标签产生的质量代码。 该方法可用于特定样品中多个目标的多路检测。 在一些实施例中，可以制备分成表示组织样本部分的部分的图，其中，图表部分包括对应于量化数据的数据，其中质量峰的大小被确定并与相应组织的靶的量相关联 样品部分。

公开(公告)号：US08306780B2

公开(公告)日：2012-11-06

申请号：US12359589

申请日：2009-01-26

申请人： Thomas H. Chyba ,  Brian Kelly

发明人： Thomas H. Chyba ,  Brian Kelly

IPC分类号： G06F11/30 ,  G21C17/00

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/44 ,  G01N2201/12 ,  G01N2201/1211 ,  G01N2201/12707

摘要： Systems and methods for operating, particularly in the field, a Raman spectroscopy device that includes a laser, a spectrograph, an intensified charge coupled device (ICCD), and an autofocus subsystem. Before spectral data acquisition commences a series of ancillary data checks is performed to monitor operating conditions of at least the laser, the ICCD, and the autofocus subsystem. Further, after each Raman spectrum acquisition, a series of data quality checks is performed to enhance confidence in the just collected data. Only spectral data that passes the data quality checks are further processed. However, all spectral data are stored in a log file. When the log file reaches a predetermined capacity, the log file is closed, and a new round of ancillary data checks is performed to again monitor the status of the Raman spectroscopy device.

摘要翻译： 包括激光器，光谱仪，强化电荷耦合器件（ICCD）和自动聚焦子系统的拉曼光谱设备的系统和方法，特别是在现场操作。 在光谱数据采集开始之前，执行一系列辅助数据检查以监视至少激光器，ICCD和自动聚焦子系统的操作条件。 此外，在每个拉曼光谱获取之后，执行一系列数据质量检查以增强刚刚收集的数据的置信度。 只有通过数据质量检查的光谱数据才能进一步处理。 然而，所有光谱数据都存储在日志文件中。 当日志文件达到预定容量时，关闭日志文件，并执行新一轮辅助数据检查，以再次监视拉曼光谱设备的状态。

公开(公告)号：US08176577B2

公开(公告)日：2012-05-15

申请号：US12984126

申请日：2011-01-04

申请人： George Grech ,  Michael Harris ,  Jason Smith ,  Steve Meyer ,  Eric Krupp ,  Brian Kelly

发明人： George Grech ,  Michael Harris ,  Jason Smith ,  Steve Meyer ,  Eric Krupp ,  Brian Kelly

IPC分类号： E03D11/00

CPC分类号： E03D5/08 ,  E03D5/012

摘要： A flush toilet includes a bowl assembly defining a bowl. The bowl assembly has a discharge outlet at a lower end and a ledge circumferentially extending about a substantial portion of the bowl. The bowl has a rear surface that is generally flat and vertical. The rear surface transitions to the ledge as the bowl continues clockwise and counter clockwise from the rear surface. A horizontal dimension of the ledge increases as the ledge continues from the rear surface to a front of the bowl. An angle of the ledge increases as the ledge continues from the rear surface to the front. A maximum slope of the ledge is located proximate the front. A nozzle is mounted to the bowl assembly for pressurizing a source of flush water and delivering the source of flush water to the bowl for rinsing and flushing of the bowl. The nozzle is positioned at a rear portion of the bowl and produces a first flow of water in a first circumferential direction about the bowl and a second flow of water in a second circumferential direction about the bowl. The second circumferential direction is opposite to the first circumferential direction. The ledge cascades the first and second flows of flush water down the bowl as the first and second flows of water move in the first and second circumferential directions, respectively.

摘要翻译： 抽水马桶包括限定碗的碗组件。 碗组件具有在下端处的排出口和围绕碗的大部分周向延伸的凸缘。 碗具有通常平坦且垂直的后表面。 当碗从后表面顺时针和逆时针继续时，后表面转变到凸缘。 凸缘的水平尺寸随着凸缘从后表面延伸到碗的前部而增加。 当凸缘从后表面延伸到前部时，凸缘的角度增加。 凸缘的最大坡度位于靠近前方的位置。 喷嘴安装到碗组件上，用于对冲洗水源进行加压，并将冲洗水源输送到碗中以冲洗和冲洗碗。 喷嘴位于碗的后部，并且在围绕碗的第一圆周方向上产生第一水流，并且在围绕碗的第二圆周方向上产生第二水流。 第二圆周方向与第一圆周方向相反。 当第一和第二水流分别在第一和第二圆周方向上移动时，突出部将冲洗水的第一和第二流动分别下降到碗下方。