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    Delivery system for co-formulated enzyme and substrate
    11.
    发明授权
    Delivery system for co-formulated enzyme and substrate 有权
    配制酶和底物的输送系统

    公开(公告)号：US08834865B2

    公开(公告)日：2014-09-16

    申请号：US13132069

    申请日：2009-11-03

    Applicant: Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    Inventor： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    IPC: A61K38/54 ,  C11D3/386 ,  C11D17/00

    CPC classification number: C11D17/0039 ,  C11D3/386 ,  C11D3/38672 ,  C11D3/38681

    Abstract: The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate.

    Abstract translation: 本发明提供包括酶/底物共递送系统的方法，组合物，系统和试剂盒。 液体递送系统包括至少一种包封在水溶性聚合物基质中的酶和在其中聚合物基质不溶性的载体液体中的酶的底物。 当加入水时，聚合物基体溶解，酶从基质中释放出来，允许对基底进行催化作用。

    Extraction of water soluble biomaterials from fluids using a carbon dioxide/surfactant mixture
    14.
    发明授权
    Extraction of water soluble biomaterials from fluids using a carbon dioxide/surfactant mixture 失效
    使用二氧化碳/表面活性剂混合物从流体中提取水溶性生物材料

    公开(公告)号：US06562605B1

    公开(公告)日：2003-05-13

    申请号：US08747474

    申请日：1996-11-12

    Applicant: Eric J. Beckman ,  Eliador J. Ghenciu ,  Nathaniel T. Becker ,  Landon M. Steele

    Inventor： Eric J. Beckman ,  Eliador J. Ghenciu ,  Nathaniel T. Becker ,  Landon M. Steele

    IPC: C07K100

    CPC classification number: C12N9/54 ,  C07K1/145 ,  C07K14/465 ,  Y02P20/544 ,  Y10S435/814

    Abstract: A method is provided for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide soluble surfactants. The extraction can be performed on an aqueous solution, a fermentation broth or a fluid. The method includes the process steps of forming a carbon dioxide/surfactant mixture which involves dissolving carbon dioxide soluble surfactant(s) in carbon dioxide. The carbon dioxide can be in a liquid or supercritical form and the surfactant includes tail and head groups that interact with the biomaterials. Further, the mixture is added to the aqueous solution, fermentation broth or liquid under conditions to allow for extraction of the biomaterials. The method further includes depressurizing and/or temperature adjusting to remove the water soluble biomaterials. The surfactants include fluroethers, oligomers of propylene-oxide, siloxanes, etc. The biomaterials include proteins or enzymes. The carbon dioxide is suberitical or supercritical.

    Abstract translation: 提供了一种利用某些二氧化碳可溶性表面活性剂将水溶性生物材料如酶或蛋白质提取到二氧化碳中的方法。 提取可以在水溶液，发酵液或流体上进行。 该方法包括形成二氧化碳/表面活性剂混合物的方法步骤，其包括将二氧化碳可溶性表面活性剂溶解在二氧化碳中。 二氧化碳可以是液体或超临界形式，并且表面活性剂包括与生物材料相互作用的尾部和头部基团。 此外，在允许提取生物材料的条件下将混合物加入到水溶液，发酵液或液体中。 该方法还包括减压和/或温度调节以除去水溶性生物材料。 表面活性剂包括氟醚，环氧丙烷的低聚物，硅氧烷等。生物材料包括蛋白质或酶。 二氧化碳是非常重要的或超临界的。

    Granule containing protein and corn starch layered on an inert particle
    15.
    发明授权
    Granule containing protein and corn starch layered on an inert particle 有权
    含有蛋白质和玉米淀粉的颗粒层叠在惰性颗粒上

    公开(公告)号：US06413749B1

    公开(公告)日：2002-07-02

    申请号：US09428153

    申请日：1999-10-27

    Applicant: Nathaniel T. Becker ,  Thomas S. Green

    Inventor： Nathaniel T. Becker ,  Thomas S. Green

    IPC: C12N998

    CPC classification number: C12N9/98 ,  Y10S530/812 ,  Y10S530/813

    Abstract: Granules are prepared containing an admixture of protein and starch layered over an inert particle. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. The admixture may also contain sugar such as sucrose. A ratio of corn starch to sugar much greater than 1:1 such as in a range of about 5:1 to about 15:1 is preferred. A coating layer may be between the inert particle and the admixture and/or over the admixture. Methods that may be used in preparing the granules include pan-coating, fluid-bed coating, prilling, disc granulation, spray drying, extrusion, centrifugal extrusion, spheronization, drum granulation and high shear agglomeration.

    Abstract translation: 制备含有在惰性颗粒上分层的蛋白质和淀粉的混合物的颗粒。 蛋白质包括药学上重要的蛋白质，例如激素或工业上重要的蛋白质，例如酶，包括蛋白酶，淀粉酶，脂肪酶和能够水解底物如污渍的纤维素酶。 惰性颗粒包括无机盐，糖，糖醇，小有机分子如有机酸或盐，以及矿物质如粘土或硅酸盐。 该混合物还可以含有糖如蔗糖。 玉米淀粉与糖的比例大大高于1：1，例如在约5:1至约15:1的范围内。 涂层可以在惰性颗粒和混合物之间和/或混合物之间。 可用于制备颗粒的方法包括泛涂，流化床涂布，造粒，盘式造粒，喷雾干燥，挤出，离心挤出，滚圆，鼓式造粒和高剪切聚集。

    Granule containing enzyme, corn starch and sugar layered on an inert particle
    18.
    发明授权
    Granule containing enzyme, corn starch and sugar layered on an inert particle 有权
    含有颗粒的酶，玉米淀粉和糖分层在惰性颗粒上

    公开(公告)号：US06790643B2

    公开(公告)日：2004-09-14

    申请号：US10180785

    申请日：2002-06-25

    Applicant: Nathaniel T. Becker ,  Thomas S. Green

    Inventor： Nathaniel T. Becker ,  Thomas S. Green

    IPC: C12N998

    CPC classification number: C12N9/98 ,  Y10S530/812 ,  Y10S530/813

    Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch and optionally sugar such as sucrose. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein. A barrier layer may surround the protein core, and a coating can be applied to the seed particle, the protein matrix and/or the barrier layer.

    Abstract translation: 描述了包含蛋白质核心的颗粒。 蛋白质核心包括蛋白质基质，其包括与淀粉和任选的糖如蔗糖一起混合的蛋白质。 蛋白质基质可以分层在种子颗粒上，或蛋白质核心可以是均质的。 蛋白质可以是酶或治疗性蛋白质。 阻挡层可以围绕蛋白质核心，并且涂层可以施加到种子颗粒，蛋白质基质和/或阻挡层。

    Granule containing protein and salt layered on an inert particle
    20.
    发明授权
    Granule containing protein and salt layered on an inert particle 有权

    公开(公告)号：US06423517B1

    公开(公告)日：2002-07-23

    申请号：US09215086

    申请日：1998-12-18

    Applicant: Nathaniel T. Becker ,  Robert I. Christensen, Jr. ,  Ernst H. Gros

    Inventor： Nathaniel T. Becker ,  Robert I. Christensen, Jr. ,  Ernst H. Gros

    IPC: C12N998

    Abstract: Granules are prepared containing an admixture of protein and salt layered over an inert particle. A preferred amount of salt is about between 63.7 and 84.3% of the total weight of the admixture. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. A binder such as starch or polyethylene oxide may be mixed in with the admixture. A barrier material such as an inorganic salt or organic acid or salt may be in the admixture or coated over the admixture layer. A coating layer of a soluble or water dispersible film-forming polymer may be between the inert particle and admixture layer and/or over the admixture layer. The granules may also contain plasticizers, extenders, lubricants, pigments and anti-agglomeration agents. A preferred method for preparing the granules is by spraying a solution or slurry of the admixture onto the inert particles while fluidized in a fluid-bed coater.

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