摘要:
The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要:
The present invention provides a process for the sulfurization of phosphorus-containing compounds. More particularly, the process involves contacting the compound to be sulfurized with a sulfur transfer reagent as defined hereinbefore in a solvent or a mixture of solvents.
摘要:
6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.
摘要:
A modular panel system having a plurality of panels connected together, each of the panels would normally be of a rectangular configuration, the panels being connected together by means of a vertically extending member which is secured to side walls of the panels and an elongated flexible interconnecting member having first and second longitudinally extending side marginal edges and an enlarged edge portion designed to be retained by the vertically extending member. A U-shaped raceway member which may be placed on either the top or bottom of a panel or between panels to provide for horizontal cables.
摘要:
The invention relates to a compound of formula (I) ##STR1## Wherein: B is adenine, guanine or hypoxanthineZ is hydrogen or a negative chargeR is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2, --CH.sub.2 CH.sub.2 X, in whichR.sup.1 is hydrogen or (C.sub.1 -.sub.6) alkylR.sup.2 is hydrogen or (C.sub.1 -.sub.6) alkyln is a number from 1 to 6X is OH, F, NR.sup.3 R.sup.4R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -.sub.6) alkyland to methods of enzymatically treating these compounds with biocatalysts having cyclic phosphodiesterase activity.
摘要翻译:本发明涉及式(I)化合物,其中B是腺嘌呤,鸟嘌呤或次黄嘌呤Z是氢或负电荷R是 - [CH 2 CH(R 1)-O] n -R 2,-CH 2 CH 2 X,其中R 1是氢 或(C 1-6)烷基R 2是氢或(C 1-6)烷基n是1至6的数X是OH,F,NR 3 R 4 R 3和R 4彼此独立地是氢或(C 1-6)烷基,并且 用具有环状磷酸二酯酶活性的生物催化剂对这些化合物进行酶处理的方法。
摘要:
There is described a process for producing fungicidally active 4-phenylpyrrole derivatives of the formula I ##STR1## wherein R is halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -haloalkyl, andn is 0, 1 or 2, which process comprises reacting a 3-trifluoromethyl-4-phenylpyrrole of the formula II ##STR2## wherein R.sub.n is as defined under the formula I, and R.sub.1 is hydrogen or an acyl group, at elevated temperature and elevated pressure, with ammonia. Important intermediates and the production thereof are also described.
摘要:
Novel substituted N-(2-pyridyloxyphenyl)-N'-benzoylureas of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another are each hydrogen, methyl or halogen,R.sub.5 is the radical --CHF.sub.2, or a C.sub.2 -C.sub.10 -alkyl group which is uniformly or nonuniformly substituted by 1 to 21 halogen atoms, andR.sub.6 is halogen,processes and starting products for producing these compounds, as well as compositions containing these, for use in combating pests, particularly for combating insects which infest plants and animals. The novel compounds have a specially high ovolarvicidal and ovicidal action against insects that damage plants.
摘要:
The preparation and use as an intermediate for making insecticides has been disclosed for a compound of the formula: ##STR1## in which X and Y are each chlorine or bromine.
摘要:
Dichlorovinylcyclobutanones of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is methyl and the other is hydrogen or methyl, or R.sub.1 and R.sub.2 together are alkylene having 2-4 C atoms, X is chlorine and Y is hydrogen, or X is hydrogen and Y is chlorine; processes for preparing them, and their use as intermediates for producing pesticidal compositions.
摘要:
A threaded connection includes first and second tubular components, each including a respective male and female end. The male and female ends each include at least one threaded zone and finish in a terminal surface. The male threaded zone includes a first portion in which a width of teeth, CWTp, increases from a value CWTpmin corresponding to a width of a tooth closest to the terminal surface of the male end to a value CWTpmax corresponding to a width of a tooth furthest from the terminal surface. A width of teeth CWTb of the female threaded zone decreases from a value CWTbmax corresponding to a width of a tooth furthest from the terminal surface of the female end to a value CWTbmin corresponding to a width of a tooth closest to the terminal surface. The threaded zones cooperate in accordance with a self-locking make-up, with CWTpmin/CWTbmax≥0.2 and CWTbmin/CWTpmax≤CWTpmin/CWTbmax.