公开(公告)号：US11312946B2

公开(公告)日：2022-04-26

申请号：US16423866

申请日：2019-05-28

Applicant: NOVOZYMES A/S

Inventor： Marco Malten ,  Kim Borch ,  Lise Munch Mikkelsen ,  Thomas Agersten Poulsen ,  Luise Erlandsen ,  Hanne Philbert Nielsen ,  Carsten Horslev Hansen ,  Allan Svendsen ,  Christian Lundager Gylstorff ,  Jesper Vind ,  Christian Jackel

IPC: C12N9/20 ,  C12N9/18 ,  C11D17/04 ,  C11D3/386 ,  B65D65/46 ,  A61K8/66

Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning.
The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.

公开(公告)号：US10760037B2

公开(公告)日：2020-09-01

申请号：US15741519

申请日：2016-07-01

Applicant: NOVOZYMES A/S

Inventor： Marco Malten ,  Thomas Agersten Poulsen ,  Lise Munch Mikkelsen ,  Dorte Marie Koefoed Klitgaard ,  Vibeke Skovgaard Nielsen ,  Katarina Larson

IPC: C12N9/20 ,  C11D3/386 ,  C11D3/12

Abstract: The present invention relates to a composition comprising: (a) a source of sulfite; and (b) a lipase variant of a parent lipase, wherein said variant has improved stability towards sulfite as compared to the parent lipase.

公开(公告)号：US20200157472A1

公开(公告)日：2020-05-21

申请号：US16749716

申请日：2020-01-22

Applicant: Novozymes A/S

Inventor： Lone Kierstein Nielsen ,  Lise Munch Mikkelsen ,  Esben Peter Friis ,  Juergen Carsten Franz Knoetzel ,  Ole Simonsen

IPC: C11D3/386 ,  C11D7/32 ,  C11D3/33 ,  C07K5/107

Abstract: Peptide aldehydes containing a ureido group are effective as stabilizers for protease in a detergent composition, and as stabilizers for a second enzyme in a liquid composition with a protease.

公开(公告)号：US20190071619A1

公开(公告)日：2019-03-07

申请号：US15741519

申请日：2016-07-01

Applicant: NOVOZYMES A/S

Inventor： Marco Malten ,  Thomas Agersten Poulsen ,  Lise Munch Mikkelsen ,  Dorte Marie Koefoed Klitgaard ,  Vibeke Skovgaard Nielsen ,  Katarina Larson

IPC: C11D3/386 ,  C11D3/12 ,  C12N9/20

Abstract: The present invention relates to a composition comprising: (a) a source of sulfite; and (b) a lipase variant of a parent lipase, wherein said variant has improved stability towards sulfite as compared to the parent lipase.

公开(公告)号：US20190218479A1

公开(公告)日：2019-07-18

申请号：US16304912

申请日：2017-05-30

Applicant: Novozymes A/S ,  Arkema Inc.

Inventor： Victor Casella ,  Lise Munch Mikkelsen ,  Priscilla Haasis ,  Danielle Rhine

IPC: C11D3/386 ,  C11D3/39

CPC classification number: C11D3/38663 ,  C11D3/38618 ,  C11D3/3947 ,  C12N9/6424 ,  C12Y304/21062

Abstract: The invention provides a liquid peroxide composition comprising a subtilisin having a M222 substitution (BPN′ numbering) and a peptide based subtilisin stabilizer.

公开(公告)号：US10308899B2

公开(公告)日：2019-06-04

申请号：US14786384

申请日：2014-04-23

Applicant: Novozymes A/S

Inventor： Hanne Philbert Nielsen ,  Lise Munch Mikkelsen ,  Martin Noerby ,  Juan Jiang

IPC: C11D3/386 ,  C07K5/062 ,  C07K5/087 ,  C07K5/072 ,  C07K5/083 ,  C07K5/09

Abstract: The stabilization of subtilisins by peptide aldehydes, hydrosulfite adducts thereof or peptide methyl ketones, is particularly effective in liquid ADW detergents which contain a strong sequestering builder.

公开(公告)号：US09809787B2

公开(公告)日：2017-11-07

申请号：US14365866

申请日：2012-12-20

Applicant: Novozymes A/S

Inventor： Jesper Vind ,  Lise Munch Mikkelsen ,  Marco Malten ,  Allan Svendsen ,  Kim Borch

IPC: C11D1/02 ,  C11D3/386 ,  C11D1/14 ,  C11D1/22

CPC classification number: C11D3/38627 ,  C11D1/02 ,  C11D1/14 ,  C11D1/22

Abstract: The present invention relates a method of obtaining a detergent composition comprising introducing (a) a lipase variant of a parent lipase which variant has at least 60% sequence identity with SEQ ID NO: 2, a substitution at a position corresponding to D254 of the mature polypeptide of SEQ ID NO: 2 and has lipase activity and (b) an anionic surfactant, wherein said composition has increased stability in comparison with a corresponding composition comprising the parent lipase.

公开(公告)号：US20160097022A1

公开(公告)日：2016-04-07

申请号：US14781211

申请日：2014-04-04

Applicant: NOVOZYMES A/S

Inventor： Lise Munch Mikkelsen

IPC: C11D3/386 ,  C11D1/22 ,  C11D17/04 ,  C11D1/29 ,  C11D3/43

CPC classification number: C11D3/38627 ,  C11D1/22 ,  C11D1/29 ,  C11D3/2003 ,  C11D3/2065 ,  C11D3/221 ,  C11D3/386 ,  C11D3/38618 ,  C11D3/43 ,  C11D17/043 ,  C11D17/045

Abstract: The present invention concerns a method for increasing the solubility of an enzyme in a liquid detergent composition comprising one or more enzymes, an anionic surfactant and a solvent system, which liquid detergent composition has a Hansen Solubility Parameter hydrogen bonding contribution (δh) in the range of 2-35. In addition, the invention concerns a liquid detergent composition and use of the detergent composition.

Abstract translation: 本发明涉及一种增加酶在包含一种或多种酶，阴离子表面活性剂和溶剂体系的液体洗涤剂组合物中的溶解度的方法，该液体洗涤剂组合物具有范围内的Hansen溶解度参数氢键贡献（δh） 的2-35。 此外，本发明涉及液体洗涤剂组合物和洗涤剂组合物的用途。

公开(公告)号：US20250002880A1

公开(公告)日：2025-01-02

申请号：US18826915

申请日：2024-09-06

Applicant: Novozymes A/S

Inventor： Marco Malten ,  Kim Borch ,  Lise Munch Mikkelsen ,  Thomas Agersten Poulsen ,  Luise Erlandsen ,  Hanne Philbert Nielsen ,  Carsten Horslev Hansen ,  Allan Svendsen ,  Christian Lundager Gylstorff ,  Jesper Vind ,  Christian Jackel

IPC: C12N9/18 ,  A61K8/66 ,  B65D65/46 ,  C11D3/386 ,  C11D17/04 ,  C12N9/20

Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning.
The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.

公开(公告)号：US12116601B2

公开(公告)日：2024-10-15

申请号：US17700598

申请日：2022-03-22

Applicant: Novozymes A/S

Inventor： Marco Malten ,  Kim Borch ,  Lise Munch Mikkelsen ,  Thomas Agersten Poulsen ,  Luise Erlandsen ,  Hanne Philbert Nielsen ,  Carsten Horslev Hansen ,  Allan Svendsen ,  Christian Lundager Gylstorff ,  Jesper Vind ,  Christian Jackel

IPC: C12N9/18 ,  A61K8/66 ,  B65D65/46 ,  C11D3/386 ,  C11D17/04 ,  C12N9/20

CPC classification number: C12N9/18 ,  A61K8/66 ,  B65D65/46 ,  C11D3/38627 ,  C11D17/042 ,  C11D17/043 ,  C12N9/20 ,  C12Y301/01003 ,  C12Y301/01

Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.