公开(公告)号：US20170224813A1

公开(公告)日：2017-08-10

申请号：US15501350

申请日：2015-08-04

Applicant: NITTO DENKO CORPORATION

Inventor： Yoshiki MAEDA ,  Arimichi OKAZAKI ,  Daisuke ASARI ,  Mitsuhiko HORI

IPC: A61K39/39 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0011 ,  A61K45/00 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55516

Abstract: The present invention aims to provide a vaccine pharmaceutical composition that can be universally used for induction of cellular immunity to various antigens and that exerts a high inducing effect. The present invention relates to a vaccine pharmaceutical composition that suppresses apoptosis of CTL or inhibits suppression of induction of CTL.

公开(公告)号：US20170007703A1

公开(公告)日：2017-01-12

申请号：US15113275

申请日：2015-01-28

Applicant: NITTO DENKO CORPORATION

Inventor： Kyohei MATSUSHITA ,  Yoshiki MAEDA ,  Wenjing LI ,  Katsuyuki OKUBO ,  Mitsuhiko HORI

IPC: A61K47/22 ,  A61K31/616 ,  A61K38/45 ,  A61K31/192 ,  A61K9/00 ,  A61K9/70

CPC classification number: A61K47/22 ,  A61K9/0014 ,  A61K9/7053 ,  A61K31/192 ,  A61K31/352 ,  A61K31/366 ,  A61K31/616 ,  A61K38/45 ,  A61K47/08 ,  C12Y207/10001 ,  A61K2300/00

Abstract: The present invention provides a skin penetration-accelerating composition that eliminates the need for forming a drug into a particle structure and dramatically improves the skin penetration properties of a drug without breaking the skin tissue. The present invention also provides a preparation for transdermal administration containing the skin penetration-accelerating composition and a patch preparation containing the skin penetration-accelerating composition. The present invention provides a skin penetration-accelerating composition containing a flavonoid compound and a surfactant and used for accelerating skin penetration of a drug.

Abstract translation: 本发明提供了一种皮肤渗透促进组合物，其消除了将药物形成颗粒结构的需要，并且显着改善药物的皮肤渗透性而不破坏皮肤组织。 本发明还提供了含有皮肤渗透促进组合物和含有皮肤渗透促进组合物的贴剂的透皮给药制剂。 本发明提供含有类黄酮化合物和表面活性剂的皮肤渗透促进组合物，用于加速药物的皮肤渗透。

公开(公告)号：US20140234377A1

公开(公告)日：2014-08-21

申请号：US14166945

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Arimichi OKAZAKI ,  Kyohei MATSUSHITA ,  Daisuke ASARI ,  Takuya SHISHIDO ,  Yoshiki MAEDA ,  Katsuyuki OKUBO ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/572

Abstract: The present invention provides a vaccine composition which comprises a cellular immunity induction promoter universally usable against various antigens in cellular immunity induction by mucosal administration of the antigen and exerts a high cellular immunity inducing effect by mucosal administration. The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.

Abstract translation: 本发明提供一种疫苗组合物，其包含通过粘膜施用抗原而在细胞免疫诱导中抵抗各种抗原通用的细胞免疫诱导启动子，并通过粘膜施用发挥高细胞免疫诱导作用。 本发明提供了用于诱导细胞免疫的粘膜给药用疫苗组合物，其包含：（i）抗原; 和（ii）选自TLR配体，环二核苷酸，辅助肽和免疫调节小分子药物的一种或多种细胞免疫诱导启动子。

公开(公告)号：US20140220063A1

公开(公告)日：2014-08-07

申请号：US14166965

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Daisuke ASARI ,  Katsuyuki OKUBO ,  Takuya SHISHIDO ,  Arimichi OKAZAKI ,  Yoshiki MAEDA ,  Kyohei MATSUSHITA ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K9/00 ,  A61K31/407 ,  A61K31/192 ,  A61K31/405 ,  A61K31/616 ,  A61K31/196 ,  A61K31/415 ,  A61K31/42 ,  A61K31/4035 ,  A61K31/353 ,  A61K31/5575 ,  A61K31/216 ,  A61K31/426 ,  A61K39/29 ,  A61K38/10 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K9/0014 ,  A61K31/192 ,  A61K31/196 ,  A61K31/216 ,  A61K31/353 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/407 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/5575 ,  A61K31/616 ,  A61K38/10 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/572

Abstract: The invention provides a vaccine composition containing an antigen for inducing cellular immunity, comprising at least one first cellular immunity induction promoter.

Abstract translation: 本发明提供含有用于诱导细胞免疫的抗原的疫苗组合物，其包含至少一种第一细胞免疫诱导启动子。

公开(公告)号：US20240024252A1

公开(公告)日：2024-01-25

申请号：US18247612

申请日：2021-10-01

Applicant: National University Corporation Hokkaido University ,  Nitto Denko Corporation

Inventor： Yusuke SATO ,  Hideyoshi HARASHIMA ,  Kazuki HASHIBA ,  Masamitsu TAGUCHI ,  Sachiko SAKAMOTO ,  Takuya SHISHIDO ,  Ayaka OTSU ,  Yoshiki MAEDA

IPC: A61K9/51 ,  C12N15/113 ,  A61K48/00 ,  C12N15/88

CPC classification number: A61K9/5123 ,  C12N15/113 ,  A61K48/0041 ,  C12N15/88 ,  C12N2320/32 ,  C12N2310/14

Abstract: The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).


(R1)(R2)C(OH)—(CH2)a—(O—CO)b—X  (I)



(R11)(R12)—CH—(CO—O)c—(CH2)v-  (A)



—(CH2)d—N(R3)(R4)  (B)