-
公开(公告)号：US20220380448A1
公开(公告)日：2022-12-01
申请号：US17816484
申请日：2022-08-01
Applicant: Pfizer Inc.
Inventor： Kevin Charles Beaumont , Danna M. Breen , Matthew Allister Lambert , Jeffrey Raymond Chabot , Tao He , Ksenya Shchors , James R. Apgar
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
-
公开(公告)号：US20210101998A1
公开(公告)日：2021-04-08
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K39/395 , A61K38/48
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
-
公开(公告)号：US08992913B2
公开(公告)日：2015-03-31
申请号：US13916379
申请日：2013-06-12
Applicant: Pfizer Inc.
Inventor： Michelle M. Mader , James R. Apgar , Kevin D. Parris
CPC classification number: C07K16/22 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/622 , C07K16/00 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
Abstract translation: 本公开提供与先前的抗GDF-8抗体相比，能够在宿主细胞中显着更高水平的表达的改进的中和抗GDF-8抗体。 还提供了使用包含此类抗体的组合物以增加肌肉质量或强度以及治疗或预防肌肉疾病，神经肌肉疾病，代谢障碍，脂肪组织病症或骨骼疾病的方法。
-
-
Search Results
13
records
(took 0.013 seconds)
