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    CLOSURE VALVE ASSEMBLY FOR A CONTAINER
    12.
    发明申请
    CLOSURE VALVE ASSEMBLY FOR A CONTAINER 有权
    集装箱封闭阀组件

    公开(公告)号：US20120031923A1

    公开(公告)日：2012-02-09

    申请号：US12850811

    申请日：2010-08-05

    申请人： Mark Smith ,  Carsten Pfromm

    发明人： Mark Smith ,  Carsten Pfromm

    IPC分类号： B65D47/00

    CPC分类号： B65D51/002 ,  B65D47/2031 ,  B65D75/5877 ,  B67D7/06

    摘要： The present invention provides a closure assembly for a container having a housing, a retaining ring and a valve. The closure assembly is useful for attachment to a container to provide flowable, aseptic access to the contents of the container.

    摘要翻译： 本发明提供了一种用于具有壳体，保持环和阀的容器的闭合组件。 闭合组件可用于连接到容器以提供可容许的，无菌的进入容器内容物的通道。

    Modified nucleotides
    13.
    发明授权
    Modified nucleotides 有权
    修饰的核苷酸

    公开(公告)号：US08071739B2

    公开(公告)日：2011-12-06

    申请号：US12804352

    申请日：2010-07-20

    申请人： John Milton ,  Xiaolin Wu ,  Mark Smith ,  Joseph Brennan ,  Colin Barnes ,  Xiaohai Liu ,  Silke Ruediger

    发明人： John Milton ,  Xiaolin Wu ,  Mark Smith ,  Joseph Brennan ,  Colin Barnes ,  Xiaohai Liu ,  Silke Ruediger

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C07H19/04 ,  C12Q1/68

    CPC分类号： C12Q1/6869 ,  C07H1/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12Q2525/186 ,  C12Q2535/113 ,  Y02P20/55 ,  C12Q2525/197

    摘要： The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.

    摘要翻译： 本发明提供了修饰的核苷酸或核苷分子，其包含嘌呤或嘧啶碱基和核糖或脱氧核糖糖部分，其具有共价连接到其上的可移除的3'-OH封闭基团，使得3'碳原子连接一组结构-O -Z其中Z是-C（R'）2 -O-R“，-C（R'）2 -N（R”）2，-C（R'）2 -N（H）R“ -C（R'）2 -S-R“和-C（R'）2 -F，其中每个R”为或可移除的保护基团的一部分; 每个R'独立地是氢原子，烷基，取代的烷基，芳基烷基，烯基，炔基，芳基，杂芳基，杂环，酰基，氰基，烷氧基，芳氧基，杂芳氧基或酰氨基，或通过连接基团连接的可检测标记; 或（R'）2表示式≡C（R'“）2的亚烷基，其中每个R”可以相同或不同，并且选自氢和卤素原子和烷基; 并且其中所述分子可以反应以产生其中每个R“被交换为H的中间体，或其中Z是-C（R'）2 -F，F被交换成OH，SH或NH 2，优选OH，其中 中间体在水性条件下解离得到具有游离3'OH的分子; 条件是其中Z是-C（R'）2 -S-R“，两个R'基团不是H.

    Face protector and protective system
    14.
    发明授权
    Face protector and protective system 有权
    面部保护和保护系统

    公开(公告)号：US07805776B2

    公开(公告)日：2010-10-05

    申请号：US11425598

    申请日：2006-06-21

    申请人： Daniel Crossman ,  Clint Alexander Hedge ,  Mark Smith ,  Justin Myles

    发明人： Daniel Crossman ,  Clint Alexander Hedge ,  Mark Smith ,  Justin Myles

    IPC分类号： A42B1/08 ,  A42B1/06 ,  F41H1/04

    CPC分类号： A42B3/326 ,  A42B3/044 ,  A42B3/185 ,  A42B3/20

    摘要： A face protector comprises a protective structure shaped for extending about a person's mandibular region and a mounting for mounting the face protector to a military combat helmet. The protective structure comprises a front portion and opposed left and right side portions extending from the front portion, the front portion having a free upper edge for positioning below eye level and above mouth level when mounted to the helmet, and being size to extend to below a person's chin. The front portion has inner and outer surfaces, and the mounting is positioned to space the inner surface and the upper edge away from the person's mouth and nose when mounted to the helmet to provide a gap for the passage of ambient air therebetween to permit unobstructed breathing. The protective structure comprises a ballistic resistant material for providing protection against high velocity fragments from explosive devices.

    摘要翻译： 面部保护器包括形状用于围绕人的下颌区域延伸的保护结构和用于将面部保护器安装到军事作战头盔的安装件。 保护结构包括前部和从前部延伸的相对的左右侧部分，前部具有自由上边缘，用于定位在眼睛水平下方并且在安装到头盔上时在嘴高度上，并且尺寸延伸到下面 一个人的下巴。 前部具有内表面和外表面，并且安装件被定位成当安装到头盔上时使内表面和上边缘远离人的嘴和鼻部，以提供用于其间的环境空气通过的间隙，以允许畅通无阻的呼吸 。 保护结构包括防弹材料，用于提供防止爆炸装置的高速碎片的保护。

    Non-nucleoside reverse transcriptase inhibitors
    16.
    发明授权
    Non-nucleoside reverse transcriptase inhibitors 失效
    非核苷逆转录酶抑制剂

    公开(公告)号：US07625897B2

    公开(公告)日：2009-12-01

    申请号：US11541011

    申请日：2006-09-29

    申请人： Yoshihito David Saito ,  Mark Smith ,  Zachary Kevin Sweeney

    发明人： Yoshihito David Saito ,  Mark Smith ,  Zachary Kevin Sweeney

    IPC分类号： C07D253/06 ,  A61K31/53 ,  A61P31/18

    CPC分类号： C07D237/04 ,  C07D237/02 ,  C07D253/06 ,  C07D253/07 ,  C07D273/04

    摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.

    摘要翻译： 本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗AIDS或ARC。 本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。 本发明还提供制备其中R 4为Al且X 1为NH或O的式I化合物的方法。

    RICH MEDIA COLLABORATION SYSTEM
    17.
    发明申请
    RICH MEDIA COLLABORATION SYSTEM 有权
    多媒体合作系统

    公开(公告)号：US20090260060A1

    公开(公告)日：2009-10-15

    申请号：US12102670

    申请日：2008-04-14

    申请人： Mark Smith ,  Kevin Anderson ,  Michael Harvey

    发明人： Mark Smith ,  Kevin Anderson ,  Michael Harvey

    IPC分类号： G06F3/048 ,  G06F21/00

    CPC分类号： H04L63/105 ,  G06Q10/10

    摘要： A user annotates a shared document with text, sound, images, video, an e-mail message, graphics, screen snapshots, web site snapshots to share with others. The document and its annotations are stored in a digital object repository to which other users have access. Within the closed collaboration system, only users who are authenticated may upload digital objects, annotate digital objects and view objects and their annotations. The user sends a message to other users to invite them to view the object and its annotations and to add their own annotations. An annotated object generates an alert for all of the invited users. A remote authentication gateway authenticates users and has a repository for user metadata. Digital object repositories are separate from the authentication gateway, thus providing for disintermediation of the user metadata from the digital object data. The collaboration system may be hosted by a third party on a server computer available over the Internet that displays a web site. A user is not required to have collaboration system software on his or her computer and may annotate any image on the web site for later viewing by other users of the web site.

    摘要翻译： 用户使用文本，声音，图像，视频，电子邮件消息，图形，屏幕快照，与其他人共享的网站快照来注释共享文档。 文档及其注释存储在其他用户可访问的数字对象存储库中。 在封闭的协作系统中，只有经过身份验证的用户才能上传数字对象，注释数字对象，查看对象及其注释。 用户向其他用户发送消息，邀请他们查看对象及其注释，并添加自己的注释。 注释对象会为所有受邀用户生成警报。 远程验证网关对用户进行身份验证，并具有用户元数据的存储库。 数字对象存储库与认证网关分离，从而提供用户元数据从数字对象数据的中介。 协作系统可以由可通过因特网可用的显示网站的服务器计算机上的第三方托管。 用户不需要在他或她的计算机上拥有协作系统软件，并且可以在网站上注释任何图像，以供该网站的其他用户稍后查看。

    Synchronous mirroring including writing image updates to a file
    18.
    发明授权
    Synchronous mirroring including writing image updates to a file 有权
    同步镜像包括将图像更新写入文件

    公开(公告)号：US07596672B1

    公开(公告)日：2009-09-29

    申请号：US10692495

    申请日：2003-10-24

    申请人： Abhijeet Gole ,  Nitin Muppalaneni ,  Mark Smith ,  Mike Federwisch

    发明人： Abhijeet Gole ,  Nitin Muppalaneni ,  Mark Smith ,  Mike Federwisch

    IPC分类号： G06F12/00

    CPC分类号： G06F11/2038 ,  G06F11/2048 ,  G06F11/2097

    摘要： A destination storage server, which may be a filer, mirrors a volume managed by a source storage server, which may also be a filer. According to an embodiment of the invention, changes made to the source volume are logged and persistently stored on a data container, such as a file, on the destination volume. The source storage server is coupled to clients that make data access requests to the volume. When an access request is made by a client, the request is written to a log on the source storage server. At the same time, the request is written to a data container on a volume managed by the destination storage server. Each source storage server coupled to the destination storage server has its own file on the volume.

    摘要翻译： 可以是文件管理器的目标存储服务器镜像由源存储服务器（也可以是文件管理器）管理的卷。 根据本发明的实施例，对源卷的变化被记录并持久地存储在目的地卷上的数据容器（诸如文件）上。 源存储服务器耦合到使数据访问请求到卷的客户端。 当客户端进行访问请求时，将请求写入源存储服务器上的日志。 同时，请求被写入由目标存储服务器管理的卷上的数据容器。 耦合到目标存储服务器的每个源存储服务器在卷上都有自己的文件。

    Data adaptation protocol
    19.
    发明授权
    Data adaptation protocol 有权
    数据适配协议

    公开(公告)号：US07586925B2

    公开(公告)日：2009-09-08

    申请号：US10658352

    申请日：2003-09-09

    申请人： Mark Smith ,  Shiping Li ,  James Pasco-Anderson

    发明人： Mark Smith ,  Shiping Li ,  James Pasco-Anderson

    IPC分类号： H04L12/28

    CPC分类号： H04J3/0685

    摘要： A gateway apparatus includes multiple network server cards which are synchronized with each other to allow time slot switching of synchronous data across an asynchronous medium between source and destination server cards. The gateway includes synchronization logic and a data adaptation layer which implements a protocol for formatting of synchronous serial data. The data undergoes serial to parallel conversion and is formed into per time slot subpackets which are further packetized along with context and synchronization data. The packet is transmitted through an asynchronous switch after which the packet is disassembled into its constituent subpackets and queued into play-out buffers according to each subpackets' associated context and synchronization data. The apparatus allows synchronous data to be switched from a source time slot to a destination time slot across the asynchronous switch with a known, fixed delay. The gateway apparatus requires only a single asynchronous switch to transmit data between and among both the synchronous and asynchronous domains.

    摘要翻译： 网关装置包括彼此同步的多个网络服务器卡，以允许在源服务器卡和目的地服务器卡之间的异步介质上的同步数据的时隙切换。 网关包括同步逻辑和实现用于格式化同步串行数据的协议的数据适配层。 数据经历串行到并行转换，并且形成为每个时隙子分组，其随着上下文和同步数据进一步分组化。 分组通过异步交换机传输，之后分组被拆分成其组成子分组，并根据每个子分组的相关上下文和同步数据排队到播出缓冲器中。 该装置允许同步数据以已知的固定延迟从异常交换机的源时隙切换到目的时隙。 网关设备只需要一个异步交换机来在同步和异步域之间进行数据传输。

    Child resistant closure for a tap
    20.
    发明申请
    Child resistant closure for a tap 有权
    用于水龙头的儿童防护盖

    公开(公告)号：US20090014479A1

    公开(公告)日：2009-01-15

    申请号：US12074349

    申请日：2008-03-04

    申请人： Mark Smith ,  Loren L. Brelje ,  James L. Richards

    发明人： Mark Smith ,  Loren L. Brelje ,  James L. Richards

    IPC分类号： B67D3/04

    CPC分类号： F16K35/025 ,  B67D3/043 ,  F16K31/508

    摘要： The present invention provides a tap assembly including: (1) a first wall defining a valve chamber having a top surface and a pair of opposed tracks extending axially along an inner surface of the wall, and a fluid outlet; (2) a tap handle mounted to the top surface for rotational movement of the tap handle with respect to the wall, the tap handle having a second wall defining an annular chamber supporting a set of threads; and (3) a generally tubular valve member having a first end and an opposed second end, the first end having a pair of lugs circumferentially spaced from one another, the lugs being positioned within the threads, the second end of the valve member extending into the valve chamber, the valve member is responsive to movement of the tap handle to move from a first position where the fluid outlet is sealed by the second end of the valve member to a second position where the fluid outlet is not sealed by the second end of the valve member and fluid is allowed to flow through the fluid outlet.

    摘要翻译： 本发明提供了一种龙头组件，其包括：（1）限定阀室的第一壁，其具有顶壁表面和沿壁的内表面轴向延伸的一对相对的轨道，以及流体出口; （2）安装在所述顶表面上用于相对于所述壁旋转移动所述水龙头的水龙头手柄，所述水龙头具有限定支撑一组螺纹的环形室的第二壁; 和（3）具有第一端和相对的第二端的大致管状的阀构件，所述第一端具有彼此周向间隔开的一对凸耳，所述凸耳定位在所述螺纹内，所述阀构件的第二端延伸到 阀室，阀构件响应于水龙头手柄的移动，以从第一位置移动，在第一位置，流体出口被阀构件的第二端密封到第二位置，在第二位置，流体出口未被第二端密封 并允许流体流过流体出口。