公开(公告)号：US20080262588A1

公开(公告)日：2008-10-23

申请号：US12163869

申请日：2008-06-27

申请人： Paul E. Zarembo ,  John Greenland

发明人： Paul E. Zarembo ,  John Greenland

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0578

摘要： A lead assembly includes an elongate body having a conductor electrically coupled with an electrode coupled to the elongate body. The lead assembly includes a push tube extending along at least a portion of the elongate body. A distal tip is coupled to the elongate body substantially adjacent to the distal end of the elongate body. The distal tip is sized and shaped to couple with a push tube distal end. In one option, the distal tip includes a seat to receive the push tube distal end. In another option, the seat is a side rail seat and a guide wire extends along the elongate body and is slidably coupled with the side rail seat. The lead assembly includes, optionally, an active fixation device slidably coupled with a portion of the elongate body, and the active fixation device is sized and shaped to couple with the push tube.

摘要翻译： 引线组件包括细长主体，其具有与耦合到细长主体的电极电耦合的导体。 引线组件包括沿细长体的至少一部分延伸的推管。 远侧末端与细长体联接，基本上与细长体的远端相邻。 远侧末端的尺寸和形状与推管远端连接。 在一个选择中，远侧末端包括用于接收推管远端的座。 在另一种选择中，座椅是侧轨座，导线沿着细长主体延伸并与侧轨座滑动联接。 引导组件可选地包括与细长主体的一部分可滑动地联接的主动固定装置，并且主动固定装置的尺寸和形状与推管相连。

公开(公告)号：US20080262586A1

公开(公告)日：2008-10-23

申请号：US12144247

申请日：2008-06-23

申请人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

发明人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0585

摘要： A pacing lead having a lead body configured into a pre-formed J-shape. The lead includes a pacing electrode coupled to an intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead is adapted to be placed within a heart in a J-shaped configuration with the electrode positioned proximate a ventricular septum or a right ventricular outflow tract such that at least a portion of the distal end of the lead body is located within a pulmonary artery. In one embodiment, the distal end of the lead is configured to be passively fixated within the pulmonary artery. Another aspect includes a lead body wherein a section of the intermediate portion of the lead body is less stiff than adjacent sections of the lead body. The lead includes a pacing electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section. The lead is adapted to be placed within a heart in a J-shaped configuration with the less stiff section near a bottom of the J-shape such that the electrode is positioned proximate a ventricular septum or a right ventricular outflow tract and at least a portion of the distal end of the lead body is fixated within a pulmonary artery.

摘要翻译： 具有构造成预成形的J形的引线主体的起搏引线。 引线包括连接到引线主体的中间部分并且位于远离预成形的J形的底部的起搏电极。 引线适于放置在J形构型的心脏内，其中电极位于心室隔膜或右心室流出道附近，使得引线体的远端的至少一部分位于肺动脉内 。 在一个实施例中，引线的远端构造成被动地固定在肺动脉内。 另一方面包括引线体，其中引线主体的中间部分的部分比引线本体的相邻部分刚性差。 引线包括连接到引线主体的中间部分并位于较不硬的部分的远侧的起搏电极。 引线适于放置在心脏内的J形构型中，具有靠近J形底部的较硬的部分，使得电极位于靠近心室隔膜或右心室流出道和至少一部分 引导体的远端固定在肺动脉内。

公开(公告)号：US20070282415A1

公开(公告)日：2007-12-06

申请号：US11422014

申请日：2006-06-02

申请人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C.B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

发明人： Bruce A. Tockman ,  Brian D. Soltis ,  Eric T. Johnson ,  Kent C.B. Stalker ,  Peter J. D'aquanni ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573 ,  A61N2001/0585

摘要： A cardiac lead adapted for fixation at least partially within a cardiac vessel. The lead includes, in one embodiment, an elongate lead body defining a proximal region and a distal region including a distal end region having at least one electrode and a distal tip. The distal end region is configured such that the electrode and the distal tip can be implanted in the cardiac vessel. Stiffening structures in the distal region of the lead are adapted to stiffen selected portions of the lead for fixation of the electrode within the cardiac vessel. In some embodiments, the stiffening structures include an implantable member adapted to be implanted in a lumen of the lead. In other embodiments, the stiffening structures include a sheath adapted to be deployed over the lead body. In still other embodiments, the stiffening structures are integral to the lead and/or the lead body.

摘要翻译： 适于至少部分地固定在心脏血管内的心脏引线。 在一个实施例中，引线包括限定近端区域的细长引线体和包括具有至少一个电极和远端尖端的远端区域的远侧区域。 远端区域被构造成使得电极和远端尖端可以植入心脏血管。 铅的远端区域中的加强结构适于加强导线的选定部分，以将电极固定在心脏血管内。 在一些实施例中，加强结构包括适于植入在引导管腔中的可植入部件。 在其他实施例中，加强结构包括适于部署在引线主体上的护套。 在其他实施例中，加强结构与引线和/或引线主体成一体。

公开(公告)号：US07238883B2

公开(公告)日：2007-07-03

申请号：US10916313

申请日：2004-08-11

申请人： Paul E. Zarembo

发明人： Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： A lead assembly includes an outer insulative body, a conductor, and at least one electrode electrically coupled with the at least one conductor. The outer insulative body extends from a proximal end to a distal end and has an intermediate portion therebetween. A flexible portion for example having a bellows portion is disposed along the lead body.

摘要翻译： 引线组件包括外绝缘体，导体和与所述至少一个导体电耦合的至少一个电极。 外绝缘体从近端延伸到远端并且在其间具有中间部分。 具有波纹管部分的柔性部分沿引线主体设置。

公开(公告)号：US06983185B2

公开(公告)日：2006-01-03

申请号：US10210192

申请日：2002-07-31

申请人： Gregory R. Ley ,  Paul E. Zarembo

发明人： Gregory R. Ley ,  Paul E. Zarembo

IPC分类号： A61N1/05 ,  A61B5/0408

CPC分类号： A61N1/0563 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3752 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/49217

摘要： A lead includes a lead body extending from a distal end to a proximal end, and at least one conductor disposed within the lead body and extending from the distal end to the proximal end of the lead body. The lead further includes an outer terminal ring, a terminal pin, and an insulative sleeve disposed between the outer terminal ring and the terminal pin, where the insulative sleeve is coupled with the outer terminal ring with a snap-fit connection. A pin latch is disposed on an outer periphery surface of the insulative sleeve, where the pin latch is rotatable about a hinge point.

公开(公告)号：US08364282B2

公开(公告)日：2013-01-29

申请号：US13006156

申请日：2011-01-13

申请人： Paul E. Zarembo ,  Elliott Rodriquez Roman

发明人： Paul E. Zarembo ,  Elliott Rodriquez Roman

IPC分类号： A61N1/00

CPC分类号： A61B5/04 ,  A61N1/04 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/0587 ,  H01R13/5224 ,  Y10T29/49172

摘要： A lead assembly includes a ring component having mechanical coupling features, and at least one polymer component mechanically coupled with the mechanical coupling features of the ring component. Elongate tubing is disposed over the polymer component and is secured with the polymer component.

摘要翻译： 导线组件包括具有机械耦合特征的环组件和与环组件的机械耦合特征机械耦合的至少一个聚合物组件。 细长管被设置在聚合物组分上并用聚合物组分固定。

公开(公告)号：US08359106B2

公开(公告)日：2013-01-22

申请号：US12557375

申请日：2009-09-10

申请人： Kalpana Viswanathan ,  Paul E. Zarembo

发明人： Kalpana Viswanathan ,  Paul E. Zarembo

IPC分类号： A61N1/04 ,  B05D5/10

CPC分类号： B29C59/142 ,  A61N1/05 ,  B29C65/4895 ,  B29C65/66 ,  B29C65/8207 ,  B29C65/8215 ,  B29C65/8223 ,  B29C66/02 ,  B29C66/0222 ,  B29C66/028 ,  B29C66/1122 ,  B29C66/5225 ,  B29C66/71 ,  B29C66/7465 ,  B29C71/0009 ,  B29K2021/00 ,  B29K2027/12 ,  B29K2083/00 ,  B29K2305/00 ,  B29K2309/08 ,  B29L2023/007 ,  B29L2031/753

摘要： Adhesiveless direct bonding between polymeric tubular members assembled with an interference fit using an oxidative cold gas plasma treatment, and implantable medical leads manufactured in part using a cold gas plasma bonding process are disclosed. An illustrative method includes subjecting a number of polymeric tubular members to an oxidative cold gas plasma, creating an oxygen rich layer on each of the tubular members. The treated surfaces of the tubular members are assembled together, forming a direct bond along an overlapping region between the tubular members when in conformal contact with each other.

摘要翻译： 公开了使用氧化冷气等离子体处理与过盈配合组装的聚合物管状构件之间的无粘合剂直接粘合，以及部分地使用冷气等离子体粘合工艺制造的可植入医疗引线。 一种说明性的方法包括使若干聚合物管状构件经受氧化冷气体等离子体，在每个管状构件上产生富氧层。 管状构件的经处理的表面组装在一起，当彼此共形接触时，沿管状构件之间的重叠区域形成直接结合。

公开(公告)号：US08221323B2

公开(公告)日：2012-07-17

申请号：US11833502

申请日：2007-08-03

申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

公开(公告)号：US20120043016A1

公开(公告)日：2012-02-23

申请号：US13216339

申请日：2011-08-24

申请人： Peter Hall ,  Paul E. Zarembo

发明人： Peter Hall ,  Paul E. Zarembo

IPC分类号： B05D3/14 ,  B32B38/08

CPC分类号： A61N1/056

摘要： A medical device having at least one glass coating between a first and second component. The glass coating forms a portion of a strong, hydrothermally stable joint between components or provides insulation, or tailors an impedance and/or capacitance of an electrode.

摘要翻译： 一种在第一和第二部件之间具有至少一个玻璃涂层的医疗装置。 玻璃涂层在部件之间形成强的，水热稳定的接头的一部分，或提供绝缘，或调整电极的阻抗和/或电容。

公开(公告)号：US08055354B2

公开(公告)日：2011-11-08

申请号：US12467978

申请日：2009-05-18

申请人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

发明人： Paul E. Zarembo ,  Mohan Krishnan ,  David Durand

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  H01R13/18 ,  H01R2201/12 ,  Y10T29/49117

摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.

摘要翻译： 可植入引线包括从引线近端部分延伸到引线远端部分的引线体。 引线体包括一个或多个纵向延伸的腔。 导体被容纳在内腔中并沿着其延伸。 在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。 在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。 在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。 在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。 在另一示例中，轴向支撑构件将远端电极和引线体联接。 还讨论了与前述相关的方法。