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    Rapid sterilization system
    11.
    发明申请
    Rapid sterilization system 审中-公开
    快速灭菌系统

    公开(公告)号：US20070014691A1

    公开(公告)日：2007-01-18

    申请号：US11414003

    申请日：2006-04-28

    申请人： Szu-Min Lin ,  Paul Jacobs ,  Jenn-Hann Wang ,  James Kohler ,  Jed Kendall ,  Harold Williams ,  Robert Lukasik

    发明人： Szu-Min Lin ,  Paul Jacobs ,  Jenn-Hann Wang ,  James Kohler ,  Jed Kendall ,  Harold Williams ,  Robert Lukasik

    IPC分类号： A61L2/24 ,  A61L2/20

    CPC分类号： A61L2/24 ,  A61L2/208 ,  A61L2202/122 ,  A61L2202/14

    摘要： A sterilization system includes a sterilization chamber, a vacuum pump associated with the sterilization chamber, a vaporizer in association with the sterilization chamber, a sterilant distillation system associated with the chamber, a source of sterilant solution associated with the vaporizer and with the sterilant distillation system, and a control system which has programmed therein a first cycle in which the sterilant is admitted to the sterilization chamber at a first concentration, and a second cycle in which sterilant is concentrated in the sterilant distillation system to a second concentration, higher than the first concentration and from there admitted into the sterilization chamber and wherein the first and second cycles are selectable.

    摘要翻译： 灭菌系统包括灭菌室，与灭菌室相连的真空泵，与灭菌室相结合的蒸发器，与该室相关联的消毒剂蒸馏系统，与蒸发器相关的灭菌剂溶液源和消毒剂蒸馏系统 ，以及控制系统，其中编程有第一循环，其中灭菌剂以第一浓度进入灭菌室;以及第二循环，其中灭菌剂在灭菌蒸馏系统中浓缩至高于第一浓度的第二循环 浓度和从那里进入灭菌室，并且其中第一和第二循环是可选择的。

    Microelectrogravimetric method for plating a biosensor
    16.
    发明授权
    Microelectrogravimetric method for plating a biosensor 有权
    用于电镀生物传感器的微电子重量法

    公开(公告)号：US06340421B1

    公开(公告)日：2002-01-22

    申请号：US09642623

    申请日：2000-08-18

    申请人： David J. Vachon ,  Jenn-Hann Wang

    发明人： David J. Vachon ,  Jenn-Hann Wang

    IPC分类号： C25D500

    CPC分类号： C12Q1/001

    摘要： Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications. The method reduce costs, provides increased reproducibility in the plating process and avoids contamination of the solution, and is particularly suited for plating of enzymes, such as glucose oxidase, or metals, such as platinum, onto electrodes for use as biosensors.

    摘要翻译： 公开了一种将电活性物质微电离沉积在电极或多个电极上的方法，包括从微分配器中分配含有电活性物质的溶液以形成悬滴液并使电极与溶液的悬滴接触，其中 电极与微型分散器电耦合以形成电化学电池，并向电化学电池施加电位。 将电活性物质沉积在电极上的潜在效应的应用。 本发明的方法消除了将电极浸入浴中的需要，将所需溶液的体积减少至少10-100倍，并避免了在连续应用中溶液的各种组分的不均匀耗尽。 该方法降低成本，在电镀过程中提供增加的再现性并避免溶液的污染，并且特别适用于将酶如葡萄糖氧化酶或诸如铂的金属电镀到用作生物传感器的电极上。

    Microelectrogravimetrically plated biosensors and apparatus for producing same
    17.
    发明授权
    Microelectrogravimetrically plated biosensors and apparatus for producing same 失效
    微电重分析电镀生物传感器及其制造装置

    公开(公告)号：US06811659B2

    公开(公告)日：2004-11-02

    申请号：US10021993

    申请日：2001-12-13

    申请人： David J. Vachon ,  Jenn-Hann Wang

    发明人： David J. Vachon ,  Jenn-Hann Wang

    IPC分类号： C25B1100

    CPC分类号： C12Q1/001

    摘要： Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications. The method reduces costs, provides for increased reproducibility in the plating process and avoids contamination of the solution, and is particularly suited for plating of enzymes, such as glucose oxidase, or metals, such as platinum, onto electrodes for use as biosensors.

    摘要翻译： 公开了一种将电活性物质微电离沉积在电极或多个电极上的方法，包括从微分配器中分配含有电活性物质的溶液以形成悬滴液并使电极与溶液的悬滴接触，其中 电极与微型分散器电耦合以形成电化学电池，并向电化学电池施加电位。 将电活性物质沉积在电极上的潜在效应的应用。 本发明的方法消除了将电极浸入浴中的需要，将所需溶液的体积减少至少10-100倍，并避免了在连续应用中溶液的各种组分的不均匀耗尽。 该方法降低了成本，提高了电镀过程中的再现性，并避免了溶液的污染，并且特别适用于将酶如葡萄糖氧化酶或诸如铂的金属电镀到用作生物传感器的电极上。

    Apparatus and process for concentrating a liquid sterilant and sterilizing articles therewith
    18.
    发明授权
    Apparatus and process for concentrating a liquid sterilant and sterilizing articles therewith 有权
    用于浓缩液体灭菌剂和与其灭菌的装置和方法

    公开(公告)号：US06325972B1

    公开(公告)日：2001-12-04

    申请号：US09223479

    申请日：1998-12-30

    申请人： Paul Jacobs ,  Suz-Min Lin ,  Jenn-Hann Wang

    发明人： Paul Jacobs ,  Suz-Min Lin ,  Jenn-Hann Wang

    IPC分类号： A61L220

    摘要： A method for sterilizing a device, includes the following steps: contacting the device with liquid sterilant outside or inside a sterilization chamber at a first pressure, placing the device in the chamber before or after the contacting step, and decreasing the pressure of the chamber to a second pressure below the vapor pressure of the liquid sterilant. At least the decrease in pressure below about the vapor pressure of the liquid sterilant occurs at a pumpdown rate of less than 0.8 liters per second, calculated based on the time required to evacuate the chamber from atmospheric pressure to 20 torr when the chamber is empty and dry.

    摘要翻译： 一种对装置进行灭菌的方法包括以下步骤：在第一压力下使装置与灭菌室外部或内部接触液体杀菌剂，在接触步骤之前或之后将该装置放置在腔室中，并将该腔室的压力降低至 第二压力低于液体杀菌剂的蒸气压。 至少低于液体灭菌剂蒸汽压力的压力降低至少以0.8升/秒的抽吸速率发生，这是基于当室为空时将室从大气压降至20托所需的时间计算的， 干。

    BLOOD CONTACTING SENSOR
    19.
    发明申请
    BLOOD CONTACTING SENSOR 有权
    血液接触传感器

    公开(公告)号：US20090149728A1

    公开(公告)日：2009-06-11

    申请号：US12264810

    申请日：2008-11-04

    申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    IPC分类号： A61B5/1468

    CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

    摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

    摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

    Blood contacting sensor
    20.
    发明授权
    Blood contacting sensor 有权
    血液接触传感器

    公开(公告)号：US07468033B2

    公开(公告)日：2008-12-23

    申请号：US10935954

    申请日：2004-09-08

    申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    IPC分类号： A61B5/00 ,  A61M37/00

    CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

    摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

    摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。