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公开(公告)号：US20060052745A1
公开(公告)日：2006-03-09
申请号：US10935954
申请日：2004-09-08
申请人： Nannette Van Antwerp , Bradley Enegren , John Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent Clark
发明人： Nannette Van Antwerp , Bradley Enegren , John Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
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公开(公告)号：US07468033B2
公开(公告)日：2008-12-23
申请号：US10935954
申请日：2004-09-08
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20090149728A1
公开(公告)日：2009-06-11
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
IPC分类号： A61B5/1468
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20050272989A1
公开(公告)日：2005-12-08
申请号：US10861837
申请日：2004-06-04
申请人： Rajiv Shah , Bahar Reghabi , Rebecca Gottlieb , Udo Hoss , John Mastrototaro
发明人： Rajiv Shah , Bahar Reghabi , Rebecca Gottlieb , Udo Hoss , John Mastrototaro
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1486 , C12Q1/005 , C12Q1/26 , G01N33/4905
摘要： Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings.
摘要翻译： 本发明的实施方案提供了具有稳定的涂料组合物的分析物传感器和用于制造和使用这种传感器 示例性实施方案包括具有稳定的葡萄糖氧化酶涂层的电化学葡萄糖传感器。
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公开(公告)号：US20110101995A1
公开(公告)日：2011-05-05
申请号：US13004660
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
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公开(公告)号：US09163273B2
公开(公告)日：2015-10-20
申请号：US12784220
申请日：2010-05-20
申请人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
发明人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca K. Gottlieb , Udo Hoss , Eric A. Grovender , Shaun M. Pendo
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译： 本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。 本发明的实施例还提供分析物传感器，例如具有涂覆有分析物感测组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的 示例性实施方案包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。
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公开(公告)号：US20110125447A1
公开(公告)日：2011-05-26
申请号：US13004691
申请日：2011-01-11
申请人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
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公开(公告)号：US20110106479A1
公开(公告)日：2011-05-05
申请号：US13004608
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundarapajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundarapajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
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公开(公告)号：US20070135698A1
公开(公告)日：2007-06-14
申请号：US11301512
申请日：2005-12-13
申请人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca Gottlieb , Udo Hoss , Eric Grovender , Shaun Pendo
发明人： Rajiv Shah , Gopikrishnan Soundararajan , Rebecca Gottlieb , Udo Hoss , Eric Grovender , Shaun Pendo
IPC分类号： A61B5/05 , B01D59/42 , B01D59/50 , B01D61/00 , C25B15/00 , C02F1/469 , B01D57/02 , C07K1/26 , C08F2/58 , C25B7/00
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译： 本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。 本发明的实施例还提供分析物传感器，例如具有涂覆有分析物感测组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的 示例性实施方案包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。
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