公开(公告)号：US20070079836A1

公开(公告)日：2007-04-12

申请号：US11610269

申请日：2006-12-13

申请人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

发明人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

IPC分类号： A61B19/00

CPC分类号： A61B5/14532 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61M39/0208

摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.

摘要翻译： 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。 优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。 此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。

公开(公告)号：US20050033263A1

公开(公告)日：2005-02-10

申请号：US10638215

申请日：2003-08-07

申请人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

发明人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

IPC分类号： A61F2/90 ,  A61M31/00

CPC分类号： A61F2/90 ,  A61F2230/0054 ,  A61M2025/105

摘要： A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.

摘要翻译： 在脉管系统内的创伤部位减轻再狭窄的系统和方法。 该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。 导管可以定位在创伤部位附近，并且再狭窄缓解药物可以通过导管输送到创伤部位。 再狭窄缓解药物或某些其他参数可由传感器检测。

公开(公告)号：US08086323B2

公开(公告)日：2011-12-27

申请号：US10669426

申请日：2003-09-23

申请人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

发明人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

IPC分类号： A61N1/05

CPC分类号： A61B5/6852 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/412 ,  A61B5/7275

摘要： A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.

摘要翻译： 一种感测多个参数的系统和方法。 该方法可以包括将可植入传感器植入患者体内并读取至少一个可植入感测元件的输出。 可植入传感器可以具有壳体，其中设置有多个可植入感测元件。 植入式感测元件中的至少一个可以响应于乳酸盐。 此外，医疗专业人员可以根据输出读取对患者进行心肌缺血，心肌梗塞心绞痛，败血症。 医疗专业人员还可以向具有可植入的心血管除颤器或正在接受体外膜氧合的患者施用。 该方法可用于外科或重症监护环境。

公开(公告)号：US20060247603A1

公开(公告)日：2006-11-02

申请号：US11477744

申请日：2006-06-28

申请人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

发明人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

IPC分类号： A61M25/00 ,  A61B5/00

CPC分类号： A61F2/90 ,  A61F2230/0054 ,  A61M2025/105

摘要： A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.

摘要翻译： 在脉管系统内的创伤部位减轻再狭窄的系统和方法。 该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。 导管可以定位在创伤部位附近，并且再狭窄缓解药物可以通过导管输送到创伤部位。 再狭窄缓解药物或某些其他参数可由传感器检测。

公开(公告)号：US20050065556A1

公开(公告)日：2005-03-24

申请号：US10669426

申请日：2003-09-23

申请人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

发明人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61N1/39

CPC分类号： A61B5/6852 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/412 ,  A61B5/7275

摘要： A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.

摘要翻译： 一种感测多个参数的系统和方法。 该方法可以包括将可植入传感器植入患者体内并读取至少一个可植入感测元件的输出。 可植入传感器可以具有壳体，其中设置有多个可植入感测元件。 植入式感测元件中的至少一个可以响应于乳酸盐。 此外，医疗专业人员可以根据输出读取对患者进行心肌缺血，心肌梗塞心绞痛，败血症。 医疗专业人员还可以向具有可植入的心血管除颤器或正在接受体外膜氧合的患者施用。 该方法可用于外科或重症监护环境。

公开(公告)号：US20060052745A1

公开(公告)日：2006-03-09

申请号：US10935954

申请日：2004-09-08

申请人： Nannette Van Antwerp ,  Bradley Enegren ,  John Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent Clark

发明人： Nannette Van Antwerp ,  Bradley Enegren ,  John Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent Clark

IPC分类号： A61M31/00 ,  A61M37/00 ,  A61B5/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

公开(公告)号：US20080077081A1

公开(公告)日：2008-03-27

申请号：US11759725

申请日：2007-06-07

申请人： R. Mounce ,  Melissa Norton ,  Robert Guezuraga ,  Bradley Enegren ,  Paul Bente ,  Ian Hanson ,  Julian Kavazov ,  Christopher Griffin ,  Sheldon Moberg ,  Mark Holt ,  Susie Maule ,  Paul Kovelman

发明人： R. Mounce ,  Melissa Norton ,  Robert Guezuraga ,  Bradley Enegren ,  Paul Bente ,  Ian Hanson ,  Julian Kavazov ,  Christopher Griffin ,  Sheldon Moberg ,  Mark Holt ,  Susie Maule ,  Paul Kovelman

IPC分类号： A61M5/172 ,  A61M5/14 ,  A61M5/145

CPC分类号： A61M5/5086 ,  A61M5/1413 ,  A61M5/14236 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/14526 ,  A61M5/1456 ,  A61M2005/14268 ,  A61M2005/14573 ,  A61M2205/0266 ,  A61M2205/103 ,  A61M2205/58 ,  A61M2205/6054 ,  Y10T29/49826

摘要： A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

摘要翻译： 输送装置包括选择性地接合和分离的第一和第二壳体部分。 一个壳体部分上的储存器可操作地接合另一壳体部分上的驱动装置和/或针插入装置。 在壳体部分适当接合时，储存器可操作地耦合到驱动装置和/或针插入装置。 第一壳体部分上的第一磁体和第二壳体部分上的第二磁体（或磁性吸引材料）定位成在壳体部分的操作接合时彼此磁性地相互作用。 第二壳体部分上的第三磁体可以与第一磁体相对，以帮助对准壳体部分用于连接。 磁体响应装置可以在一个或两个壳体部分上，以检测壳体部分的对准和/或连接。

公开(公告)号：US20070112261A1

公开(公告)日：2007-05-17

申请号：US11466532

申请日：2006-08-23

申请人： Bradley Enegren ,  David Kerr

发明人： Bradley Enegren ,  David Kerr

IPC分类号： A61B5/00

CPC分类号： A61B5/0002 ,  A61B5/18 ,  A61B5/7445 ,  B60K28/063 ,  G06F19/3418

摘要： An automobile monitoring system is for monitoring patient body characteristics. The automobile monitoring system includes at least one sensor to monitor at least one patient body characteristic, at least one transmitter operatively coupled to the at least one sensor to communicate sensor data, at least one monitor operatively coupled to the at least one transmitter to receive the sensor data, and automobile electronics operatively coupled to the at least one transmitter to receive sensor data. The at least one monitor and the automobile electronics display the sensor data to the patient. The at least one transmitter communicates with the at least one monitor and the automobile electronics using at least one wireless protocol including Bluetooth, infrared, radio frequency, 802.11a, 802.11b, or 802.11g. The automobile electronics include at least one of a GPS navigation system, a DVD entertainment system, an on-system computer, or a stereo system.

摘要翻译： 汽车监控系统用于监测患者的身体特征。 所述汽车监控系统包括至少一个用于监测至少一个患者身体特征的传感器，至少一个发射器，可操作地耦合到所述至少一个传感器以传送传感器数据;至少一个监视器，可操作地耦合到所述至少一个发射器， 传感器数据和可操作地耦合到所述至少一个发射器的汽车电子装置以接收传感器数据。 至少一个监视器和汽车电子装置将传感器数据显示给患者。 至少一个发射机使用至少一个包括蓝牙，红外，射频，802.11a，802.11b或802.11g的无线协议与至少一个监视器和汽车电子通信。 汽车电子产品包括GPS导航系统，DVD娱乐系统，系统计算机或立体声系统中的至少一个。

公开(公告)号：US20060253085A1

公开(公告)日：2006-11-09

申请号：US11149119

申请日：2005-06-08

申请人： Eric Geismar ,  Bradley Enegren ,  Paul Kovelman

发明人： Eric Geismar ,  Bradley Enegren ,  Paul Kovelman

IPC分类号： A61M5/32 ,  A61B5/00

CPC分类号： A61M5/14244 ,  A61B5/14532 ,  A61B2562/0295 ,  A61M5/14248 ,  A61M5/1723 ,  A61M2005/14252 ,  A61M2005/1726 ,  A61M2205/15 ,  A61M2205/8206 ,  A61M2230/201

摘要： A dual insertion set includes a base, an infusion portion, a sensor portion, and at least one piercing member. The base is adapted to secure the dual insertion set to the skin of a patient. The infusion portion includes a cannula for supplying a fluid to a placement site. The cannula is coupled to and extends from the base and has at least one lumen with a distal end for fluid communication with the placement site. The cannula has at least one port structure formed near another end of the lumen opposite the distal end. The sensor portion includes a sensor coupled to and extending from the base having at least one sensor electrode formed on a substrate. The sensor is for determining a body characteristic of the patient at the placement site. The at least one piercing member is coupled to and extends from the base to facilitate insertion of the cannula and the sensor.

摘要翻译： 双插入组包括基座，输注部分，传感器部分和至少一个刺穿构件。 基座适于将双重插入件固定到患者的皮肤上。 输注部分包括用于将流体供应到放置位置的套管。 套管联接到基座并从基座延伸并且具有至少一个具有远端的内腔，用于与放置位置的流体连通。 插管具有至少一个端口结构，其形成在与远端相对的内腔的另一端附近。 传感器部分包括传感器，该传感器耦合到基底并且具有在基底上形成的至少一个传感器电极的基底。 传感器用于确定放置位置处患者的身体特征。 所述至少一个刺穿构件联接到所述底座并从所述底座延伸，以便于所述套管和所述传感器的插入。

公开(公告)号：US20050148928A1

公开(公告)日：2005-07-07

申请号：US10749468

申请日：2003-12-31

申请人： Adam Molina ,  Poonam Gulati ,  Bradley Enegren ,  Eric Geismar ,  Philip Hudak

发明人： Adam Molina ,  Poonam Gulati ,  Bradley Enegren ,  Eric Geismar ,  Philip Hudak

IPC分类号： A61L29/04 ,  A61L29/06 ,  A61L29/08 ,  B32B1/08 ,  B32B27/36 ,  C08L23/06 ,  C08L23/08 ,  C08L75/04 ,  F16L11/04 ,  F16L11/06 ,  A61M31/00

CPC分类号： B32B1/08 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  B32B27/08 ,  B32B27/304 ,  B32B27/306 ,  B32B27/32 ,  B32B27/36 ,  B32B27/40 ,  B32B2307/546 ,  B32B2323/043 ,  B32B2597/00 ,  C08L23/06 ,  C08L23/0853 ,  C08L75/04 ,  F16L11/06 ,  Y10T428/1393 ,  C08L23/08 ,  C08L67/02

摘要： A multiple layer tubing for conveying a fluidic media in a medical or laboratory environment includes at least one outer layer of a copolyester ether (COPE) material. The tubing also includes an inner layer of a material compatible with sensitive fluidic media and at least one intermediate layer for bonding the outer layer to the inner layer. The material of the inner layer may be a high density polyethylene or a polyurethane material. The material of the intermediate layer may be ethylene-vinyl acetate (EVA). With the use of a COPE outer layer, a multiple layer medical tubing may be made without polyvinylchloride (PVC) or PVC plasticizers. The multiple layer tubing may be made by extrusion. The three layers may be co-extruded, simultaneously, as part of an efficient manufacturing processes.

摘要翻译： 用于在医疗或实验室环境中输送流体介质的多层管道包括共聚酯醚（COPE）材料的至少一个外层。 管道还包括与敏感流体介质相容的材料的内层和用于将外层粘合到内层的至少一个中间层。 内层的材料可以是高密度聚乙烯或聚氨酯材料。 中间层的材料可以是乙烯 - 乙酸乙烯酯（EVA）。 通过使用COPE外层，可以在不使用聚氯乙烯（PVC）或PVC增塑剂的情况下制造多层医用管。 多层管可以通过挤压制成。 作为有效制造工艺的一部分，三层可以同时共挤出。