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23 条记录 (耗时 0.037 秒)

    Blood contacting sensor
    1.
    发明授权
    Blood contacting sensor 有权
    血液接触传感器

    公开(公告)号：US07468033B2

    公开(公告)日：2008-12-23

    申请号：US10935954

    申请日：2004-09-08

    申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    IPC分类号： A61B5/00 ,  A61M37/00

    CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

    摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

    摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

    BLOOD CONTACTING SENSOR
    2.
    发明申请
    BLOOD CONTACTING SENSOR 有权
    血液接触传感器

    公开(公告)号：US20090149728A1

    公开(公告)日：2009-06-11

    申请号：US12264810

    申请日：2008-11-04

    申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

    IPC分类号： A61B5/1468

    CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

    摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

    摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

    Monitoring of cleaning process
    4.
    发明授权
    Monitoring of cleaning process 有权
    清洁过程监控

    公开(公告)号：US07246627B2

    公开(公告)日：2007-07-24

    申请号：US10326041

    申请日：2002-12-20

    申请人： Paul T. Jacobs ,  Jenn-Hann Wang ,  Szu-Min Lin

    发明人： Paul T. Jacobs ,  Jenn-Hann Wang ,  Szu-Min Lin

    IPC分类号： B08B3/02

    CPC分类号： A61L2/186 ,  A61B90/70 ,  A61L2/183 ,  A61L2202/17 ,  A61L2202/24 ,  B08B3/00

    摘要： An apparatus for monitoring a cleaning process for a medical device includes a cleaning chamber for receiving and cleaning the instrument with a cleaning liquid, a receiving well within the cleaning chamber, a removable soil standard receivable within the receiving well whereby to be exposed to the cleaning process within the cleaning chamber; and a soil detector coupled to the cleaning chamber and adapted to provide an indication of the amount of the soil on the soil standard while the soil standard is received within the receiving well.

    摘要翻译： 一种用于监测医疗装置的清洁过程的装置包括清洁室，用于接收和清洁具有清洁液体的仪器，清洁室内的接收井，可接收在接收井内的可移除的土壤标准，从而暴露于清洁 清洁室内的过程; 以及土壤检测器，其耦合到所述清洁室并且适于在所述接收井内接收到土壤标准的同时提供土壤标准上土壤的量的指示。

    Microelectrogravimetric method for plating a biosensor
    6.
    发明授权
    Microelectrogravimetric method for plating a biosensor 有权
    用于电镀生物传感器的微电子重量法

    公开(公告)号：US06340421B1

    公开(公告)日：2002-01-22

    申请号：US09642623

    申请日：2000-08-18

    申请人： David J. Vachon ,  Jenn-Hann Wang

    发明人： David J. Vachon ,  Jenn-Hann Wang

    IPC分类号： C25D500

    CPC分类号： C12Q1/001

    摘要： Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications. The method reduce costs, provides increased reproducibility in the plating process and avoids contamination of the solution, and is particularly suited for plating of enzymes, such as glucose oxidase, or metals, such as platinum, onto electrodes for use as biosensors.

    摘要翻译： 公开了一种将电活性物质微电离沉积在电极或多个电极上的方法，包括从微分配器中分配含有电活性物质的溶液以形成悬滴液并使电极与溶液的悬滴接触，其中 电极与微型分散器电耦合以形成电化学电池，并向电化学电池施加电位。 将电活性物质沉积在电极上的潜在效应的应用。 本发明的方法消除了将电极浸入浴中的需要，将所需溶液的体积减少至少10-100倍，并避免了在连续应用中溶液的各种组分的不均匀耗尽。 该方法降低成本，在电镀过程中提供增加的再现性并避免溶液的污染，并且特别适用于将酶如葡萄糖氧化酶或诸如铂的金属电镀到用作生物传感器的电极上。

    Microelectrogravimetrically plated biosensors and apparatus for producing same
    8.
    发明授权
    Microelectrogravimetrically plated biosensors and apparatus for producing same 失效
    微电重分析电镀生物传感器及其制造装置

    公开(公告)号：US06811659B2

    公开(公告)日：2004-11-02

    申请号：US10021993

    申请日：2001-12-13

    申请人： David J. Vachon ,  Jenn-Hann Wang

    发明人： David J. Vachon ,  Jenn-Hann Wang

    IPC分类号： C25B1100

    CPC分类号： C12Q1/001

    摘要： Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications. The method reduces costs, provides for increased reproducibility in the plating process and avoids contamination of the solution, and is particularly suited for plating of enzymes, such as glucose oxidase, or metals, such as platinum, onto electrodes for use as biosensors.

    摘要翻译： 公开了一种将电活性物质微电离沉积在电极或多个电极上的方法，包括从微分配器中分配含有电活性物质的溶液以形成悬滴液并使电极与溶液的悬滴接触，其中 电极与微型分散器电耦合以形成电化学电池，并向电化学电池施加电位。 将电活性物质沉积在电极上的潜在效应的应用。 本发明的方法消除了将电极浸入浴中的需要，将所需溶液的体积减少至少10-100倍，并避免了在连续应用中溶液的各种组分的不均匀耗尽。 该方法降低了成本，提高了电镀过程中的再现性，并避免了溶液的污染，并且特别适用于将酶如葡萄糖氧化酶或诸如铂的金属电镀到用作生物传感器的电极上。

    Sterilization of diffusion-restricted area by revaporizing the condensed vapor
    9.
    发明授权
    Sterilization of diffusion-restricted area by revaporizing the condensed vapor 失效
    通过蒸发冷凝蒸气灭菌扩散限制区域

    公开(公告)号：US06451254B1

    公开(公告)日：2002-09-17

    申请号：US09223594

    申请日：1998-12-30

    申请人： Jenn-Hann Wang ,  Szu-Min Lin ,  Paul T. Jacobs

    发明人： Jenn-Hann Wang ,  Szu-Min Lin ,  Paul T. Jacobs

    IPC分类号： A01N100

    CPC分类号： A61L2/208 ,  A01N25/18 ,  A01N59/00 ,  A61L2/14 ,  A61L2202/122 ,  A61L2202/24 ,  A01N2300/00

    摘要： A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.

    摘要翻译： 一种通过在室中引入消毒剂来消毒扩散受限区域的内部的方法，使蒸汽冷凝，减小腔室中的压力以再蒸发冷凝的蒸汽，并将该装置保持在腔室中，直到该装置被灭菌。 灭菌剂的蒸气压小于水的蒸气压，优选为过氧化氢。 保持室内的装置的腔室中的压力可以保持恒定，变化或增加。 另外可以将等离子体引入腔室以提高灭菌速率。

    Apparatus and process for concentrating a liquid sterilant and sterilizing articles therewith
    10.
    发明授权
    Apparatus and process for concentrating a liquid sterilant and sterilizing articles therewith 有权
    用于浓缩液体灭菌剂和与其灭菌的装置和方法

    公开(公告)号：US06325972B1

    公开(公告)日：2001-12-04

    申请号：US09223479

    申请日：1998-12-30

    申请人： Paul Jacobs ,  Suz-Min Lin ,  Jenn-Hann Wang

    发明人： Paul Jacobs ,  Suz-Min Lin ,  Jenn-Hann Wang

    IPC分类号： A61L220

    摘要： A method for sterilizing a device, includes the following steps: contacting the device with liquid sterilant outside or inside a sterilization chamber at a first pressure, placing the device in the chamber before or after the contacting step, and decreasing the pressure of the chamber to a second pressure below the vapor pressure of the liquid sterilant. At least the decrease in pressure below about the vapor pressure of the liquid sterilant occurs at a pumpdown rate of less than 0.8 liters per second, calculated based on the time required to evacuate the chamber from atmospheric pressure to 20 torr when the chamber is empty and dry.

    摘要翻译： 一种对装置进行灭菌的方法包括以下步骤：在第一压力下使装置与灭菌室外部或内部接触液体杀菌剂，在接触步骤之前或之后将该装置放置在腔室中，并将该腔室的压力降低至 第二压力低于液体杀菌剂的蒸气压。 至少低于液体灭菌剂蒸汽压力的压力降低至少以0.8升/秒的抽吸速率发生，这是基于当室为空时将室从大气压降至20托所需的时间计算的， 干。