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公开(公告)号：US09481730B2
公开(公告)日：2016-11-01
申请号：US13498390
申请日：2010-09-27
申请人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
发明人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
CPC分类号： C07K16/2878 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及包含对死亡受体特异性的第一抗原结合位点和第二抗原特异性的第二抗原结合位点的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120184718A1
公开(公告)日：2012-07-19
申请号：US13498390
申请日：2010-09-27
申请人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
发明人： Peter Bruenker , Claudia Ferrara Koller , Sandra Grau , Sylvia Herter , Christoph Lampert , Ekkehard Moessner , Pablo Umana , Inja Waldhauer
CPC分类号： C07K16/2878 , C07K16/18 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及包含对死亡受体特异性的第一抗原结合位点和第二抗原特异性的第二抗原结合位点的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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13.发明申请公开(公告)号：US20100256338A1
公开(公告)日：2010-10-07
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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14.发明授权Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function 有权融合构建体及其使用以产生具有增加的Fc受体结合亲和力和效应子功能的抗体公开(公告)号：US08367374B2
公开(公告)日：2013-02-05
申请号：US10761435
申请日：2004-01-22
申请人： Pablo Umaña , Peter Bruenker , Claudia Ferrara , Tobias Suter
发明人： Pablo Umaña , Peter Bruenker , Claudia Ferrara , Tobias Suter
CPC分类号： C07K16/2887 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/05 , C12N9/1051 , C12N9/2488 , C12N15/62 , C12P21/005 , C12Y204/01038 , C12Y204/01144 , C12Y302/01024 , C12Y302/01096 , C12Y302/01114
摘要： The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
摘要翻译： 本发明涉及蛋白质的糖基化工程领域。 更具体地说，本发明涉及具有催化活性的核酸分子，包括具有催化活性的核糖分子，以及其在宿主细胞糖基化工程中的用途，以产生具有改善的治疗性质的多肽，包括具有增加的Fc受体结合和增加的效应子功能的抗体。
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公开(公告)号：US20080248510A1
公开(公告)日：2008-10-09
申请号：US12056310
申请日：2008-03-27
申请人： Ulrich Brinkmann , Peter Bruenker , Claudia Ferrara Koller , Martin Lanzendoerfer , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Anne Zeck
发明人： Ulrich Brinkmann , Peter Bruenker , Claudia Ferrara Koller , Martin Lanzendoerfer , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Anne Zeck
IPC分类号： G01N33/53 , G01N33/566 , C12P21/04 , C07K14/00
CPC分类号： C07K14/70535 , G01N2333/70535
摘要： The present invention relates to the field of human immunoglobulin receptors, specifically the glycostructure of a human Fc gamma receptor IIIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.
摘要翻译： 本发明涉及人免疫球蛋白受体的领域，特别涉及人胚胎肾细胞和中国仓鼠卵巢细胞中重组表达的人Fcγ受体IIIa的糖结构。
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