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11.发明申请公开(公告)号：US20080294027A1
公开(公告)日：2008-11-27
申请号：US11823098
申请日：2007-06-25
申请人： Peter Frinking , Marcel Arditi , Nicolas Rognin
发明人： Peter Frinking , Marcel Arditi , Nicolas Rognin
IPC分类号： A61B5/145
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part, means for associating the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape includes an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion, means for determining at least one shape indicator of the probability density distribution, and means for comparing the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.
摘要翻译： 提出了灌注评估系统。 该系统包括用于在毁坏身体部位中的大部分造影剂之后提供指示生物体的身体部分中的造影剂再灌注的回波功率信号的装置， 根据具有所述S形的多个基本灌注函数的具有S形的灌注功能的功能信号，每个具有至少一个灌注参数的对应值，所述基本灌注函数根据概率密度分布进行加权 所述至少一个灌注参数，其中所述S形包括具有基本为零的一阶导数的初始部分，具有基本为零的一阶导数的最终部分，以及初始部分与最终部分之间的中心部分从 初始部分到最终部分的值，用于确定概率密度分布的至少一个形状指示符的装置 离子，以及用于将所述至少一个形状指示器与至少一个预定的另外的形状指示器进行比较的装置，以根据比较的结果来识别身体部位的形态特征。
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公开(公告)号：US08929634B2
公开(公告)日：2015-01-06
申请号：US13393633
申请日：2010-09-01
申请人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
发明人： Nicolas Rognin , Marcel Arditi , Laurent Mercier , Peter Frinking
CPC分类号： G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location.
摘要翻译： 提出了一种用于分析患者身体部位的实施例。 相应的数据处理方法包括以下步骤：在分析周期内提供表示身体部分的输入图像序列，每个输入图像包括一组输入值，每个输入值指示对相应位置的询问信号的响应 在分析周期中包括的相应采集时刻的身体部分相关联，将时间分析功能与一组选定位置中的每一个相关联，分析功能模拟所选位置的输入值的趋势， 输入图像，并提供分析功能的时间参考功能; 在一个实施例中，数据处理方法还包括将每个所选择的位置的分析功能与参考功能进行比较，以确定代表所选位置的分析功能的极性的分析周期的趋势的极性趋势和 参考功能，以及创建包括每个选定位置的参数值的参数图像，参数值表示所选位置的极性趋势。
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13.发明授权公开(公告)号：US08021303B2
公开(公告)日：2011-09-20
申请号：US11823098
申请日：2007-06-25
申请人： Peter Frinking , Marcel Arditi , Nicolas Rognin
发明人： Peter Frinking , Marcel Arditi , Nicolas Rognin
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part, means for associating the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape includes an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion, means for determining at least one shape indicator of the probability density distribution, and means for comparing the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.
摘要翻译： 提出了灌注评估系统。 该系统包括用于在毁坏身体部位中的大部分造影剂之后提供指示生物体的身体部分中的造影剂再灌注的回波功率信号的装置， 根据具有所述S形的多个基本灌注函数的具有S形的灌注功能的功能信号，每个具有至少一个灌注参数的对应值，所述基本灌注函数根据概率密度分布进行加权 所述至少一个灌注参数，其中所述S形包括具有基本为零的一阶导数的初始部分，具有基本为零的一阶导数的最终部分，以及初始部分与最终部分之间的中心部分从 初始部分到最终部分的值，用于确定概率密度分布的至少一个形状指示符的装置 离子，以及用于将所述至少一个形状指示器与至少一个预定的另外的形状指示器进行比较的装置，以根据比较的结果来识别身体部位的形态特征。
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公开(公告)号：US20080139942A1
公开(公告)日：2008-06-12
申请号：US11885723
申请日：2006-03-03
申请人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
发明人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
IPC分类号： A61B8/00
CPC分类号： A61K49/223 , Y10S128/916
摘要： A medical imaging system is proposed. The system includes means for providing a plurality of echo signals indicative of a response of a body part to a plurality of ultrasound pulsed waves having different acoustic pressures, the body part including a tissue being perfused with a contrast agent, and means for discriminating in the echo signals a contribution of a first type of contrast agent from a contribution of a second type of contrast agent and/or of the tissue, at least one harmonic component of the contribution of the first type of contrast agent having an acoustic power changing according to a first dependency law on the acoustic pressure and the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue having an acoustic power changing according to at least one second dependency law on the acoustic pressure, wherein the means for discriminating includes means for significantly reducing the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue with respect to the at least one harmonic component of the contribution of the first type of contrast agent according to the corresponding dependency laws.
摘要翻译： 提出了一种医学成像系统。 该系统包括用于提供指示体部分对具有不同声压的多个超声脉冲波的响应的多个回波信号的装置，身体部分包括用造影剂灌注的组织，以及用于在 回波信号是来自第二类型的造影剂和/或组织的贡献的第一类型的造影剂的贡献，第一类型的造影剂的贡献的至少一个谐波分量具有根据 第二类造影剂和/或组织的声压和至少一个谐波分量的第一依赖规律具有根据至少一个第二依赖规律改变的声功率对声压，其中 用于鉴别的装置包括用于显着减少第二类型c的贡献的至少一个谐波分量的装置 根据相应的依赖规律相对于第一类型造影剂的贡献的至少一个谐波分量的组织和/或组织。
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公开(公告)号：US10278612B2
公开(公告)日：2019-05-07
申请号：US13127389
申请日：2009-11-23
申请人： Peter Frinking , Laurent Mercier , Nicolas Rognin , Marcel Arditi
发明人： Peter Frinking , Laurent Mercier , Nicolas Rognin , Marcel Arditi
IPC分类号： A61B5/055 , A61B8/06 , A61B8/08 , G01R33/563 , A61B6/00
摘要： A solution for diagnostic applications is proposed. Particularly, a corresponding diagnostic system includes means (903-906) for providing (A1-A3) a plurality of input signals representative of a body-part being perfused with a contrast agent over time, each input signal being indicative of a response to an interrogating stimulus of a corresponding location of the body-part possibly including the contrast agent, means (909-930) for generating (A4.1-A4.3) a plurality of filtered signals from selected input signals of selected locations, each filtered signal at each instant over time being generated from a corresponding selected input signal according to a portion of the selected input signal including said instant, and means (933-939) for monitoring (A4.4-A4.6) each filtered signal to detect a peak in the response to the interrogation stimulus of the corresponding selected location, the peak being detected in response to the fulfillment of a stability condition by a corresponding portion of the filtered signal.
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16.发明授权公开(公告)号：US10130342B2
公开(公告)日：2018-11-20
申请号：US13607354
申请日：2012-09-07
申请人： Peter Frinking , Nicolas Rognin , Marcel Arditi
发明人： Peter Frinking , Nicolas Rognin , Marcel Arditi
摘要： An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent.
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公开(公告)号：US09307957B2
公开(公告)日：2016-04-12
申请号：US13377143
申请日：2010-06-08
CPC分类号： A61B8/5215 , A61B5/72 , A61B6/5211 , A61B8/06 , A61B8/481 , G06T5/009 , G06T5/40 , G06T2207/10132
摘要： A data-processing method includes providing a parametric map including a plurality of parameter values, each one characterizing a corresponding location of a body-part. The method includes determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations.
摘要翻译： 数据处理方法包括提供包括多个参数值的参数图，每个参数值表征身体部位的对应位置。 该方法包括确定对应于所选分析位置的多个分析参数值的至少一个分布的至少一个统计指标，每个统计指标指示由分析位置定义的身体部分的分析区域的状况。
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18.发明授权公开(公告)号：US08634608B2
公开(公告)日：2014-01-21
申请号：US12084934
申请日：2006-11-10
申请人： Peter Frinking , Nicolas Rognin , Marcel Arditi
发明人： Peter Frinking , Nicolas Rognin , Marcel Arditi
IPC分类号： G06K9/00
CPC分类号： G06T5/50 , A61B8/06 , A61B8/481 , G06T5/008 , G06T5/40 , G06T2207/10016 , G06T2207/10132 , G06T2207/30004
摘要： An embodiment of a system is proposed for imaging a body part including a tissue, the body part being perfused with a contrast agent. The system includes means for providing a sequence of original images offering a digital representation over time of the body-part, each original image including a plurality of original values each one indicative of a response to an interrogation signal of a corresponding location of the body-part possibly including the contrast agent with a contribution of the tissue substantially reduced. The system further includes means for generating an overlaid image for each one of a set of selected original images, for each one of a set of selected locations the overlaid image including an overlaid value consisting of a) a linearized value derived from the corresponding original value to be substantially proportional to a concentration of the contrast agent in the selected location when the linearized value reaches a predefined threshold, or otherwise b) a compressed value depending non-linearly on the corresponding response to the interrogation signal; and means for displaying the overlaid images in succession.
摘要翻译： 提出了一种系统的实施例，用于对包括组织的身体部位进行成像，身体部分被造影剂灌注。 该系统包括用于提供在身体部位随时间提供数字表示的原始图像序列的装置，每个原始图像包括多个原始值，每个原始值指示对身体部分的对应位置的询问信号的响应， 部分可能包括造影剂与组织的贡献显着减少。 该系统还包括用于为一组所选位置中的每一个生成针对一组所选原始图像中的每一个的重叠图像的装置，所述重叠图像包括由a）从相应的原始值导出的线性化值 当线性化值达到预定阈值时，与所选择的位置中的造影剂的浓度成基本成比例，或者b）与对询问信号的相应响应呈非线性关系的压缩值; 以及用于连续显示重叠图像的装置。
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公开(公告)号：US07846100B2
公开(公告)日：2010-12-07
申请号：US11885723
申请日：2006-03-03
申请人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
发明人： Emmanuel Gaud , Peter Frinking , Nicolas Rognin , Sibylle Pochon , Nathalie Biolluz , Marcel Arditi
IPC分类号： A61B8/14
CPC分类号： A61K49/223 , Y10S128/916
摘要： A medical imaging system is proposed. The system includes means for providing a plurality of echo signals indicative of a response of a body part to a plurality of ultrasound pulsed waves having different acoustic pressures, the body part including a tissue being perfused with a contrast agent, and means for discriminating in the echo signals a contribution of a first type of contrast agent from a contribution of a second type of contrast agent and/or of the tissue, at least one harmonic component of the contribution of the first type of contrast agent having an acoustic power changing according to a first dependency law on the acoustic pressure and the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue having an acoustic power changing according to at least one second dependency law on the acoustic pressure, wherein the means for discriminating includes means for significantly reducing the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue with respect to the at least one harmonic component of the contribution of the first type of contrast agent according to the corresponding dependency laws.
摘要翻译： 提出了一种医学成像系统。 该系统包括用于提供指示体部分对具有不同声压的多个超声脉冲波的响应的多个回波信号的装置，身体部分包括用造影剂灌注的组织，以及用于在 回波信号是来自第二类型的造影剂和/或组织的贡献的第一类型的造影剂的贡献，第一类型的造影剂的贡献的至少一个谐波分量具有根据 关于第二类造影剂和/或具有根据至少一个第二依赖规律改变声学力的组织的声压和至少一个谐波分量对声压的第一依赖规律，其中 用于鉴别的装置包括用于显着减少第二类型c的贡献的至少一个谐波分量的装置 根据相应的依赖规律相对于第一类型造影剂的贡献的至少一个谐波分量的组织和/或组织。
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公开(公告)号：US20080228080A1
公开(公告)日：2008-09-18
申请号：US11794182
申请日：2005-12-21
申请人： Marcel Arditi , Peter Frinking , Nicolas Rognin
发明人： Marcel Arditi , Peter Frinking , Nicolas Rognin
IPC分类号： A61B8/00
摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a perfusion of a contrast agent in a body-part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body-part, means for associating the echo-power signal to a model function including the product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and means for estimating at least one perfusion indicator from the bolus function and/or the reperfusion function.
摘要翻译： 提出了灌注评估系统。 该系统包括用于提供指示在分析的身体部位中的造影剂的灌注的回波功率信号的装置，所述造影剂作为推注施用并在造影剂在体内通过期间经历显着的破坏 - 将所述回波功率信号与模型功能相关联的模块功能，所述模型功能包括所述产品在指示所述造影剂通过之前没有所述破坏的推注功能和指示所述造影剂在体内部分再灌注的再灌注功能 对应于造影剂的基本上恒定的流入的破坏，以及用于从推注功能和/或再灌注功能估计至少一个灌注指示符的装置。
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