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公开(公告)号：US5434131A
公开(公告)日：1995-07-18
申请号：US67684
申请日：1993-05-26
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K20060101 , C07K14/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/00 , C07K16/28 , C07K16/42 , C07K19/00 , C12N5/06 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/564 , G01N33/566 , G01N33/577
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/02 , C07K2319/30 , C07K2319/32 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US06887471B1
公开(公告)日：2005-05-03
申请号：US09454651
申请日：1999-12-06
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , A61K38/17 , C12N15/12 , C12N15/63
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： This invention provides methods for regulating T cell interactions with B7 positive cells. Methods are provided for using B7 antigen, its fragments and derivatives reactive with CTLA4 receptor, to regulate CTLA4 positive T cell responses, and immune responses mediated by T cells.
摘要翻译： 本发明提供了调节与B7阳性细胞的T细胞相互作用的方法。 提供了使用B7抗原及其与CTLA4受体反应的衍生物调节CTLA4阳性T细胞应答和T细胞介导的免疫应答的方法。
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公开(公告)号：US5977318A
公开(公告)日：1999-11-02
申请号：US488062
申请日：1995-06-07
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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公开(公告)号：US5521288A
公开(公告)日：1996-05-28
申请号：US219116
申请日：1994-03-29
IPC分类号： A61K38/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N15/12 , G01N33/569 , C07K16/46 , C07H21/04 , C07K14/00
CPC分类号： C07K14/70532 , C07K14/705 , C07K14/70521 , C07K16/2803 , C07K16/2818 , C07K16/2827 , G01N33/56972 , A61K38/00 , C07K2317/73 , C07K2319/00 , Y10S514/885 , Y10S530/866 , Y10S530/867 , Y10S530/868
摘要： The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C.gamma.1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
摘要翻译： 本发明将B7抗原鉴定为与T细胞上的CD28受体反应的配体。 描述了B7抗原和CD28受体的片段和衍生物，包括与编码部分人免疫球蛋白Cγ1的氨基酸序列连接的与B7或CD28的细胞外结构域相对应的氨基酸序列的融合蛋白。 提供了使用B7抗原，其片段和衍生物以及CD28受体，其片段和衍生物以及与B7抗原和/或CD28受体反应的抗体和其它分子调节CD28阳性T细胞应答的方法，以及 由T细胞介导的免疫应答。 本发明还包括检测与介导细胞间粘附的细胞受体反应的配体的测定方法。
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公开(公告)号：US07572772B2
公开(公告)日：2009-08-11
申请号：US11725384
申请日：2007-03-19
IPC分类号： C07K14/705
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US07070776B1
公开(公告)日：2006-07-04
申请号：US08459766
申请日：1995-06-02
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： G01N33/56972 , A61K38/00 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/2818 , C07K16/2827 , C07K2317/74 , C07K2319/00
摘要： The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. The invention further provides methods for using antibodies to B7, or fragments thereof, to regulate CD28 positive T cell response and immune responses mediated by T cells.
摘要翻译： 本发明将B7抗原鉴定为与T细胞上的CD28受体反应的配体。 本发明还提供了使用B7抗体或其片段调节CD28阳性T细胞应答和由T细胞介导的免疫应答的方法。
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公开(公告)号：US5968510A
公开(公告)日：1999-10-19
申请号：US725776
申请日：1996-10-04
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K39/395
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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公开(公告)号：US5885579A
公开(公告)日：1999-03-23
申请号：US889666
申请日：1997-07-08
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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公开(公告)号：US5851795A
公开(公告)日：1998-12-22
申请号：US459818
申请日：1995-06-02
IPC分类号： A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12P21/08 , A61K38/02 , A61K39/395
CPC分类号： C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S424/809 , Y10S424/81 , Y10S530/861 , Y10S530/866 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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20.发明授权Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules 失效使用B7结合分子和IL4结合分子调节免疫应答的方法
公开(公告)号：US5770197A
公开(公告)日：1998-06-23
申请号：US8898
申请日：1993-01-22
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P31/12 , A61P31/14 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K20060101 , C07K14/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/00 , C07K16/28 , C07K16/42 , C07K19/00 , C12N5/06 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/564 , G01N33/566 , G01N33/577 , C07K16/46
CPC分类号： C07K16/2827 , C07K14/70521 , C07K14/7155 , C07K16/2818 , A61K38/00 , C07K2317/73 , C07K2319/02 , C07K2319/036 , C07K2319/30 , C07K2319/32 , Y10S424/81 , Y10S530/868
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译： 本发明鉴定CTLA4受体作为B7抗原的配体。 提供编码人CTLA4受体基因的完整氨基酸序列。 提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导 通过这种互动。
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