公开(公告)号：US20220401562A1

公开(公告)日：2022-12-22

申请号：US17569720

申请日：2022-01-06

Applicant: President and Fellows of Harvard College

Inventor： Yevgeny Brudno ,  Cathal J. Kearney ,  Eduardo Alexandre Barros E Silva ,  Michael Aizenberg ,  Brian Kwee ,  Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney

IPC: A61K47/54 ,  A61K9/00 ,  A61K9/06 ,  A61K47/69 ,  A61K47/36 ,  A61K31/704 ,  A61K49/00 ,  C12N15/113

Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.

公开(公告)号：US20200291078A1

公开(公告)日：2020-09-17

申请号：US15776998

申请日：2016-11-18

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Quoc Nguyen

IPC: C07K14/435 ,  C07K14/78 ,  C07K14/47

Abstract: Methods of making recombinant secretion of silk and silk-amyloid proteins using bacteria are provided.

公开(公告)号：US20250161536A1

公开(公告)日：2025-05-22

申请号：US18752542

申请日：2024-06-24

Applicant: President and Fellows of Harvard College

Inventor： Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney ,  Sandeep T. Koshy ,  Alexander Stafford

IPC: A61L27/52 ,  A61L27/20 ,  A61L27/22 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54 ,  C07D237/26 ,  C07K14/78 ,  C08B37/00

Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.

公开(公告)号：US20220280575A1

公开(公告)日：2022-09-08

申请号：US17698596

申请日：2022-03-18

Applicant: President and Fellows of Harvard College

Inventor： Peter Q. Nguyen ,  Neel Satish Joshi

IPC: A61K35/74 ,  C07K14/245 ,  C12P21/02 ,  A61P1/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  C07K19/00

Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.

公开(公告)号：US11365225B2

公开(公告)日：2022-06-21

申请号：US15776998

申请日：2016-11-18

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Quoc Nguyen

IPC: C07K19/00 ,  C07K14/435 ,  C12N15/70 ,  C07K14/47 ,  C07K14/78 ,  C12N1/20 ,  C12R1/19

Abstract: Methods of making recombinant secretion of silk and silk-amyloid proteins using bacteria are provided.

公开(公告)号：US11352397B2

公开(公告)日：2022-06-07

申请号：US16713368

申请日：2019-12-13

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Q. Nguyen ,  Zsofia Magarian

IPC: C07K14/245 ,  C07K14/21

Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.

公开(公告)号：US11286491B2

公开(公告)日：2022-03-29

申请号：US16785874

申请日：2020-02-10

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Q. Nguyen ,  Anna M. Duraj-Thatte ,  Pichet Praveschotinunt

IPC: C12N15/62 ,  C07K14/245 ,  A61K35/74 ,  A61P1/00 ,  C07K14/33 ,  C12N15/70

Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.

公开(公告)号：US20190201457A1

公开(公告)日：2019-07-04

申请号：US16328303

申请日：2017-08-31

Applicant: President and Fellows of Harvard College

Inventor： Peter Q. Nguyen ,  Neel Satish Joshi

IPC: A61K35/74 ,  A61K9/00 ,  C07K19/00 ,  C07K14/245 ,  A61K9/20 ,  A61K9/48 ,  A61K9/02 ,  A61P1/00

CPC classification number: A61K35/74 ,  A61K9/0031 ,  A61K9/0056 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61P1/00 ,  C07K14/245 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/036 ,  C07K2319/21 ,  C12P21/02

Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.

公开(公告)号：US20180186840A1

公开(公告)日：2018-07-05

申请号：US15808237

申请日：2017-11-09

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Q. Nguyen ,  Zsofia Magarian

IPC: C07K14/245 ,  C07K14/21

CPC classification number: C07K14/245 ,  C07K14/21 ,  C07K2319/20 ,  C07K2319/735

Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.

公开(公告)号：US20170189581A1

公开(公告)日：2017-07-06

申请号：US15301466

申请日：2015-04-06

Applicant: President and Fellows of Harvard College

Inventor： Rajiv Desai ,  Neel Satish Joshi ,  David J. Mooney ,  Sandeep T. Koshy ,  Alexander G. Stafford

IPC: A61L27/52 ,  A61L27/38 ,  C07K14/78 ,  A61L27/22 ,  A61L27/54 ,  C08B37/00 ,  A61L27/26 ,  A61L27/20

Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.