摘要:
The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要:
The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要:
An image is saved to a contact record or set as a home screen directly from a camera application of a portable electronic device. The method includes: capturing an image using a camera that is integrated into the portable electronic device, selecting at least a portion of the image, selecting a contact record from an address book application or selecting a set as home screen option.
摘要:
Displaying information in a column of a user interface (UI) on a display screen is enhanced by a column scroll control that displays information that is otherwise truncated from display in the space allocated to the column. The control is sensitive to a threshold limited scrolling input from a user to activate the display of the information ticker style. The display of the remainder of the user interface may be maintained while the column is scrolled. The controls are advantageous for trackball and similar pointing devices especially those used with handheld wireless communication devices (cellular phones, PDAs, smart phones, etc.) where one handed operation is desirable and where display screen sizes and resolutions often require truncation of information in a particular column entry or entries.
摘要:
System and method that provides audible feedback through a speaker of a handheld electronic device upon actuation of a navigation tool. The audible feedback produced by the speaker is capable of being modified based upon the location, speed, and other characteristics of the movement of a cursor on the display of a handheld electronic device. The sound produced by the speaker can originate from an audio file stored or otherwise available on the handheld electronic device.
摘要:
A novel method and apparatus for controlling operation of a photosensor array in a portable electronic device to reduce flicker resulting from fluorescent light having a periodic intensity. The method comprises selecting a time zone in which the device is to be operated, correlating the time zone with a corresponding frequency of the fluorescent light, and signaling the photosensor array to operate in accordance with a mode optimized to reduce flicker based on the selected time zone.
摘要:
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要:
Selected compounds are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要:
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要:
A method and application for previewing themes for a mobile device are provided. Theme files comprising theme preview files are stored on the mobile device for each theme that can be activated. The theme preview files comprise an image representing the appearance of the theme when activated. The images may be displayed in a preview pane in a theme option. The theme preview files may also be displayed in a list for those themes that are not stored on the mobile device but are available to be downloaded. The list can be updated as new themes become available by polling a new theme service. A theme builder for creating theme definitions and theme preview files, and web interfaces for previewing and downloading new themes are also provided.