公开(公告)号：US20230390287A1

公开(公告)日：2023-12-07

申请号：US18235392

申请日：2023-08-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Helena FLORINDO ,  Rita GUEDES ,  Rita ACÚRCIO

IPC: A61K31/506 ,  A61K31/428 ,  A61K31/351 ,  A61K31/135 ,  A61K31/44

CPC classification number: A61K31/506 ,  A61K31/428 ,  A61K31/44 ,  A61K31/135 ,  A61K31/351

Abstract: Compounds (small molecules) capable of interfering with an interaction between PD-1 and PD-L1, and thereby are usable in treating cancer and/or in increasing T-cell function and/or in treating a medical condition associate with PD1, PD-L1 and/or T-cell function on cells, pharmaceutical compositions and kits comprising same and uses thereof, are provided.

公开(公告)号：US20220111029A1

公开(公告)日：2022-04-14

申请号：US17418977

申请日：2019-12-27

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Helena FLORINDO ,  Joao CONNIOT ,  Anna SCOMPARIN

IPC: A61K39/00 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/395 ,  A61K45/06 ,  A61K47/69 ,  A61K39/39 ,  A61P35/00

Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle; (ii) at least one adjuvant; and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.

公开(公告)号：US20170182176A1

公开(公告)日：2017-06-29

申请号：US15447257

申请日：2017-03-02

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Ela MARKOVSKY ,  Hemda BAABUR-COHEN

IPC: A61K47/48 ,  A61K31/704 ,  A61K31/337 ,  C08G69/08 ,  A61K9/51

CPC classification number: A61K47/48315 ,  A61K31/337 ,  A61K31/704 ,  A61K38/484 ,  A61K47/55 ,  A61K47/58 ,  A61K47/593 ,  A61K47/64 ,  A61K47/645 ,  A61K2300/00

Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.

公开(公告)号：US20170014531A1

公开(公告)日：2017-01-19

申请号：US15124360

申请日：2015-03-13

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/48

CPC classification number: A61K49/0054 ,  A61K31/337 ,  A61K47/58 ,  A61K47/593 ,  A61K47/65 ,  A61K49/0032

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

Abstract translation: 公开了可用于有机应用的聚合体系。 聚合体系包含荧光或荧光部分和治疗活性剂，各自连接到相同或不同的聚合物部分。 聚合物体系被设计成使得响应于化学事件产生荧光信号，优选在接触在患病组织或器官中过度表达的分析物（例如酶）时产生荧光信号。 还公开了可用于包含在这种聚合物体系中的探针，制备这种探针的方法和聚合物体系，以及其在诊断和/或治疗应用中的用途。

公开(公告)号：US20200078475A1

公开(公告)日：2020-03-12

申请号：US16687789

申请日：2019-11-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Doron SHABAT ,  Rachel BLAU ,  Yana EPSHTEIN ,  Hemda BAABUR-COHEN ,  Shiran FERBER ,  Orit REDY-KEISAR ,  Einat KISIN-FINFER

IPC: A61K49/00 ,  A61K31/337 ,  A61K47/65 ,  A61K47/59 ,  A61K47/58

Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

公开(公告)号：US20190290787A1

公开(公告)日：2019-09-26

申请号：US16072848

申请日：2017-01-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron SHABAT ,  Ronit SATCHI-FAINARO ,  Nir HANANYA ,  Ori GREEN ,  Tal EILON

IPC: A61K49/00 ,  C07H15/26 ,  C07F5/04 ,  C07F9/655 ,  C09K11/06 ,  C09B11/24 ,  C09B23/08 ,  C09B23/04

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.

公开(公告)号：US20190060477A1

公开(公告)日：2019-02-28

申请号：US16079123

申请日：2017-02-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K47/59 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/04

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.

公开(公告)号：US20160095838A1

公开(公告)日：2016-04-07

申请号：US14970660

申请日：2015-12-16

Applicant: Universita degli Studi di Padova ,  Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Gianfranco PASUT

IPC: A61K31/337 ,  A61K49/00 ,  A61K47/48

CPC classification number: A61K31/337 ,  A61K47/24 ,  A61K47/548 ,  A61K47/56 ,  A61K47/60 ,  A61K47/641 ,  A61K49/0008 ,  A61K49/0054 ,  G01N33/5091 ,  G01N33/574

Abstract: Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

Abstract translation: 聚合物缀合物，其包含连接有骨靶向部分和治疗活性剂的聚合物主链，其中骨靶向部分通过支化单元连接到聚合物骨架的一端，使得骨靶向部分与聚合物的摩尔比 至少为2：1。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。

公开(公告)号：US20150328330A1

公开(公告)日：2015-11-19

申请号：US14816228

申请日：2015-08-03

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Keren MILLER ,  Doron SHABAT ,  Rotem EREZ

IPC: A61K47/48 ,  A61K49/00 ,  A61K31/337

CPC classification number: A61K47/48084 ,  A61K9/1676 ,  A61K31/337 ,  A61K47/548 ,  A61K47/58 ,  A61K47/65 ,  A61K49/0017 ,  A61K49/0054 ,  A61K2800/57 ,  C07F9/3873 ,  C07F9/65517 ,  C07F9/65586 ,  C07K5/06078 ,  C07K5/1008

Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

Abstract translation: 公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。