公开(公告)号：US20230265480A1

公开(公告)日：2023-08-24

申请号：US18184249

申请日：2023-03-15

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron SHABAT ,  Michal Eli ROTH-KONFORTI ,  Nir HANANYA ,  Ori GREEN ,  Urs SPITZ ,  Lukas WICK ,  Julian IHSSEN ,  Raffael VORBERG ,  Riccardo CRIBIU ,  Zuzana BABJAKOVÀ ,  Chunyan YAO

IPC: C12Q1/04 ,  C12Q1/54

CPC classification number: C12Q1/04 ,  C12Q1/54

Abstract: A method is for the detection of presence or absence, quantification, and identification of target microorganisms, such as bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence. The method include providing a medium with one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the dioxetane compound emits light, and detecting the emitted light.

公开(公告)号：US20200237932A1

公开(公告)日：2020-07-30

申请号：US16850333

申请日：2020-04-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron SHABAT ,  Ronit SATCHI-FAINARO ,  Nir HANANYA ,  Ori GREEN ,  Tal EILON

IPC: A61K49/00 ,  C07H15/26 ,  C07F9/12 ,  C09B11/24 ,  C07D321/00 ,  C07F7/18 ,  C09B23/01 ,  C09B23/04 ,  C07F5/02 ,  C07F5/04 ,  C09B23/08 ,  C07F9/655 ,  C09K11/06 ,  C07H15/203

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US20210214766A1

公开(公告)日：2021-07-15

申请号：US17058623

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron SHABAT ,  Michal Eli ROTH-KONFORTI ,  Nir HANANYA ,  Ori GREEN ,  Urs SPITZ ,  Lukas WICK ,  Julian IHSSEN ,  Raffael VORBERG ,  Riccardo CRIBIU ,  Zuzana BABJAKOVÀ ,  Chunyan YAO

IPC: C12Q1/10 ,  C07D407/04 ,  C07D321/00 ,  C12Q1/44 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/76

Abstract: Dioxetane compounds can be used in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods. A method for the detection of a target analyte, a target microorganism or a target metabolite includes providing a medium including one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the compound emits light, and detecting the emitted light.

公开(公告)号：US20210214607A1

公开(公告)日：2021-07-15

申请号：US17058453

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Julian IHSSEN ,  Urs SPITZ ,  Doron SHABAT ,  Ori GREEN ,  Nir HANANYA

IPC: C09K11/06 ,  C07F5/04 ,  C07D405/10 ,  C07D321/00 ,  G01N33/58 ,  G01N21/76

Abstract: Improved long wavelength-emitting chemiluminescent probes are easy to synthesize and are well-suited for both in vitro and in vivo applications, but are particularly well-suited for in vivo applications. The wavelengths of the emissions of the probes include those in the orange, red or NIR range. Dioxetane compounds and phenolic ester compounds are included.

公开(公告)号：US20230094870A1

公开(公告)日：2023-03-30

申请号：US17904527

申请日：2021-02-17

Applicant: Ramot at Tel-Aviv University Ltd. ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： Doron SHABAT ,  Ori GREEN ,  Matthew BOGYO

IPC: C07D321/00 ,  C12Q1/18 ,  C12Q1/04

Abstract: Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light.

公开(公告)号：US20190290787A1

公开(公告)日：2019-09-26

申请号：US16072848

申请日：2017-01-24

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron SHABAT ,  Ronit SATCHI-FAINARO ,  Nir HANANYA ,  Ori GREEN ,  Tal EILON

IPC: A61K49/00 ,  C07H15/26 ,  C07F5/04 ,  C07F9/655 ,  C09K11/06 ,  C09B11/24 ,  C09B23/08 ,  C09B23/04

Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.