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11.发明授权公开(公告)号：US09670147B2
公开(公告)日：2017-06-06
申请号：US14753297
申请日：2015-06-29
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07C271/24 , C07C275/26 , C07C311/07 , C07D209/56 , C07D211/44 , C07D231/12 , C07D261/08 , C07J63/00 , C07C311/09 , C07D307/20 , C07D487/08 , C07D295/195
CPC分类号： C07C255/47 , C07C271/24 , C07C275/26 , C07C311/07 , C07C311/09 , C07C2603/52 , C07D209/56 , C07D211/44 , C07D231/12 , C07D261/08 , C07D295/195 , C07D307/20 , C07D487/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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12.发明授权C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof 有权齐墩果酸的C17-烷二基和烯二基衍生物及其使用方法公开(公告)号：US09593074B2
公开(公告)日：2017-03-14
申请号：US14022986
申请日：2013-09-10
IPC分类号： C07C255/47 , C07J63/00 , C07D207/08 , C07D207/12 , C07D211/46 , C07D213/75 , C07D233/90 , C07D295/205 , C07D305/08
CPC分类号： C07J63/008 , C07C255/47 , C07D207/08 , C07D207/12 , C07D211/46 , C07D213/75 , C07D233/90 , C07D295/205 , C07D305/08
摘要： Disclosed herein are novel C17-alkanediyl and alkenediyl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
摘要翻译： 本文公开了齐墩果酸的新C17-烷二基和亚烯基二基衍生物，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物的方法，例如抗氧化剂炎症调节剂及其组合物。
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13.发明授权A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof 有权A环环氧化三萜类抗炎调节剂及其使用方法公开(公告)号：US09556222B2
公开(公告)日：2017-01-31
申请号：US14406854
申请日：2013-06-14
发明人： Eric Anderson , Christopher F. Bender , Xin Jiang , Xiaofeng Liu , Haizhou Sun , Melean Visnick
IPC分类号： C07J71/00 , C07J75/00 , C07D493/22 , A61K31/336 , C07J63/00
CPC分类号： C07J71/001 , A61K31/336 , C07D493/22 , C07J63/008 , C07J75/00
摘要： Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.
摘要翻译： 本文公开了新型的A环环氧化三萜化合物及其衍生物，包括式（I）的那些，其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用化合物的方法，例如抗氧化剂炎症调节剂及其组合物。
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14.发明授权公开(公告)号：US09278912B2
公开(公告)日：2016-03-08
申请号：US14023180
申请日：2013-09-10
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
IPC分类号： A61K31/343 , A61K31/16 , A61K31/122 , C07C69/74 , C07C233/58 , C07C35/44 , C07D307/00 , C07C255/47 , C07J63/00
CPC分类号： C07C255/47 , C07D307/00 , C07J63/008
摘要： Disclosed herein are novel C13-hydroxy derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
摘要翻译： 本文公开了齐墩果酸的新C13-羟基衍生物，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物的方法，例如抗氧化剂炎症调节剂及其组合物。
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15.发明授权Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring 有权抗氧化剂炎症调节剂：C环中饱和的齐墩果酸衍生物公开(公告)号：US09090574B2
公开(公告)日：2015-07-28
申请号：US13867797
申请日：2013-04-22
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： C07C49/115 , C07D285/12 , C07D271/10 , C07D257/04 , C07D491/22 , C07D313/06 , C07C61/125 , C07C233/00 , C07C69/753 , C07D261/20 , C07D207/27 , C07C69/757 , C07D413/08 , C07J63/00
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
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16.再颁专利公开(公告)号：USRE45325E1
公开(公告)日：2015-01-06
申请号：US14080414
申请日：2013-11-14
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： A61K31/277 , C07C255/03 , C07D223/14 , C07D285/12 , C07D271/10 , C07D313/06 , C07D257/04
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US11827664B2
公开(公告)日：2023-11-28
申请号：US17055331
申请日：2019-05-14
发明人： Xin Jiang , Melean Visnick , Christopher F. Bender , Gary Bolton , Bradley Caprathe , Chitase Lee
IPC分类号： C07H15/203 , A61P25/02 , C07H1/00
CPC分类号： C07H15/203 , A61P25/02 , C07H1/00
摘要： Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases associated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (III), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.
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公开(公告)号：US10398711B2
公开(公告)日：2019-09-03
申请号：US15861241
申请日：2018-01-03
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
IPC分类号： A61K31/58 , C07D271/10 , C07D271/06 , C07J63/00
摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
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19.发明申请公开(公告)号：US20190119202A1
公开(公告)日：2019-04-25
申请号：US16115028
申请日：2018-08-28
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07D487/08 , C07D295/195 , C07D211/44 , C07D231/12 , C07C311/07 , C07D209/56 , C07J63/00 , C07D307/20 , C07D261/08 , C07C311/09 , C07C275/26 , C07C271/24
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US09889143B2
公开(公告)日：2018-02-13
申请号：US15349086
申请日：2016-11-11
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick
CPC分类号： A61K31/58 , C07D271/06 , C07D271/10 , C07J63/008
摘要： Disclosed herein are novel C17-heteroaryl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
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