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公开(公告)号：US11293914B2
公开(公告)日：2022-04-05
申请号：US16393177
申请日：2019-04-24
IPC: G01N33/497 , G01N27/22 , G01N27/12
Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.
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公开(公告)号：US20210356457A1
公开(公告)日：2021-11-18
申请号：US17387503
申请日：2021-07-28
Inventor： Xue Zhen , Philippe Pierre Joseph Buhlmann , Steven Koester , Yao Zhang , Justin Theodore Nelson
Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.
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公开(公告)号：US11079371B2
公开(公告)日：2021-08-03
申请号：US16280635
申请日：2019-02-20
Inventor： Xue Zhen , Philippe Pierre Joseph Buhlmann , Steven J. Koester , Yao Zhang , Justin Theodore Nelson
IPC: G01N33/53 , G01N27/12 , G01N27/22 , A61B5/08 , G01N27/414
Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.
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公开(公告)号：US20190254538A1
公开(公告)日：2019-08-22
申请号：US16280644
申请日：2019-02-20
Inventor： Arthur Guy Erdman , Gregory J. Sherwood , Gregory Kermit Peterson , Justin Theodore Nelson , Michael Mathias Freking
IPC: A61B5/0205 , A61B5/00
Abstract: Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling mask. The breath sampling mask can include a mask housing configured to cover a portion of the face of a patient. The mask housing can define a breath receiving chamber. The breath sampling mask can include a chemical sensor element in fluid communication with the breath sampling mask, where the chemical sensor element can include a plurality of discrete binding detectors. The chemical sensor element can interface with a breath sample collected through the breath sampling mask. Other embodiments are also included herein.
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公开(公告)号：US12007385B2
公开(公告)日：2024-06-11
申请号：US17941364
申请日：2022-09-09
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Gregory Kermit Peterson , Justin Theodore Nelson , Gregory J. Sherwood
IPC: G01N33/497 , G01N1/22 , G01N27/22
CPC classification number: G01N33/497 , G01N1/2226 , G01N27/227 , G01N2001/2244 , G01N33/4972
Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.
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Patent Agency Ranking
公开(公告)号：US11835435B2
公开(公告)日：2023-12-05
申请号：US16696348
申请日：2019-11-26
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Gregory J. Sherwood , Justin Theodore Nelson
CPC classification number: G01N1/2226 , G01N27/22 , G16H15/00 , G16H20/00 , G16H50/20 , G16H50/30 , G01N2001/2229 , G01N2027/222
Abstract: Embodiments herein include a method for detecting a health condition of a subject. The method can include obtaining a biological sample from the subject and placing it into a container having a headspace surrounding the biological sample. The method can include contacting a gas from the headspace with a chemical sensor element, the chemical sensor element including one or more discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set. Other embodiments are also included herein.
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公开(公告)号：US11662325B2
公开(公告)日：2023-05-30
申请号：US16712255
申请日：2019-12-12
Inventor： Gregory J. Sherwood , Justin Theodore Nelson , Steven J. Koester
CPC classification number: G01N27/021 , G01N27/221 , G01N27/227 , G01N33/0036
Abstract: Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.
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公开(公告)号：US20220334075A1
公开(公告)日：2022-10-20
申请号：US17719760
申请日：2022-04-13
Inventor： Steven Koester , Qun Su , Philippe Pierre Joseph Buhlmann , Xue Zhen , Justin Theodore Nelson , Gregory J. Sherwood
IPC: G01N27/22 , G01N33/497
Abstract: Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.
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公开(公告)号：US20210369250A1
公开(公告)日：2021-12-02
申请号：US17328478
申请日：2021-05-24
IPC: A61B10/00 , C01B32/194 , C01G7/00
Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor. The graphene varactor includes a graphene layer and at least one non-covalent modification layer disposed on an outer surface of the graphene layer. The non-covalent modification layer can include nanoparticles selected from a group that can include one or more metals, metal oxides, or derivatives thereof. Other embodiments are also included herein.
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公开(公告)号：US11166636B2
公开(公告)日：2021-11-09
申请号：US16280644
申请日：2019-02-20
Inventor： Arthur Guy Erdman , Gregory J. Sherwood , Gregory Kermit Peterson , Justin Theodore Nelson , Michael Mathias Freking
Abstract: Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling mask. The breath sampling mask can include a mask housing configured to cover a portion of the face of a patient. The mask housing can define a breath receiving chamber. The breath sampling mask can include a chemical sensor element in fluid communication with the breath sampling mask, where the chemical sensor element can include a plurality of discrete binding detectors. The chemical sensor element can interface with a breath sample collected through the breath sampling mask. Other embodiments are also included herein.
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