公开(公告)号：US20240043903A1

公开(公告)日：2024-02-08

申请号：US18268560

申请日：2021-12-17

Applicant: PROTEOMETECH INC.

Inventor： Kook Jin LIM ,  Han Seung JOO ,  Je Seung OH ,  Chang Su LIM

IPC: C12Q1/18 ,  G01N27/02 ,  G01N27/30

CPC classification number: C12Q1/18 ,  G01N27/021 ,  G01N27/30

Abstract: The present invention relates to a biosensor for inspecting the susceptibility of a microorganism to an antibiotic, a fabrication method therefor, and a method for inspecting the susceptibility of a microorganism to an antibiotic by using same, wherein the biosensor comprises: a substrate including polyethylene terephthalate; and a sensor part formed on one surface or both surfaces of the substrate and comprising an electrode inclusive of a first electrode and a second electrode which interdigitate with each other.

公开(公告)号：US20230405872A1

公开(公告)日：2023-12-21

申请号：US18035482

申请日：2021-11-17

Applicant: THE BOARD OF REGENTS FOR THE OKLAHOMA GRICULTURAL AND MECHANICAL COLLEGES

Inventor： Lichun Chen ,  Tyler Ley

IPC: B28B17/00 ,  G01N27/02 ,  B28B11/24

CPC classification number: B28B17/0081 ,  G01N27/021 ,  B28B11/245

Abstract: A system and method monitoring the properties of curing concrete systems to assist in adjusting curing conditions to produce predetermined properties in the hardened or cured concrete. The apparatus and method achieves this by providing a low-cost, minimally invasive means for gaining insight into the conditions of the curing concrete by using electrical impedance analysis. Sensors are distributed throughout the system to collect and transmit electrical impedance data, which is then interpreted in reference to correlations with other relevant physical and chemical properties.

公开(公告)号：US20230393087A1

公开(公告)日：2023-12-07

申请号：US18144506

申请日：2023-05-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Steven Koester

IPC: G01N27/02 ,  G01N27/22

CPC classification number: G01N27/021 ,  G01N27/221 ,  G01N27/227 ,  G01N33/0036

Abstract: Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.

公开(公告)号：US10067121B2

公开(公告)日：2018-09-04

申请号：US14541024

申请日：2014-11-13

Applicant: ACEA Biosciences, Inc.

Inventor： Yama A. Abassi ,  Naichen Yu ,  Josephine Atienza ,  Xiao Xu ,  Xiaobo Wang

IPC: G01N33/50 ,  C12Q1/00 ,  G01N27/02 ,  G01N33/543

CPC classification number: G01N33/5041 ,  C12Q1/002 ,  G01N27/021 ,  G01N33/5014 ,  G01N33/5438 ,  G01N2333/4716 ,  G01N2333/705 ,  G01N2333/91205 ,  G01N2500/04 ,  G01N2500/10

Abstract: Use of cell-substrate impedance based methods for screening for agonists of G-Protein Coupled Receptors (GPCRs) or inhibitors of a Receptor Tyrosine Kinases (RTKs), identifying compounds that affect GPCR or RTK pathways, validating molecular targets involved in a GPCR or RTK signaling pathways, monitoring dose-dependent functional activation of GPCR or RTK; determining desensitization of a GPCR and identifying a compound capable of affecting RTK activity in cancer cell proliferation.

公开(公告)号：US20180231514A1

公开(公告)日：2018-08-16

申请号：US15376562

申请日：2016-12-12

Applicant: University of Utah Research Foundation

Inventor： Hanseup Kim ,  Carlos Mastrangelo

IPC: G01N33/00 ,  G01N27/02 ,  B01D46/00 ,  A62D3/11

CPC classification number: G01N33/0057 ,  A62D3/11 ,  B01D46/0032 ,  B01L2300/0645 ,  B82Y15/00 ,  B82Y40/00 ,  G01N27/021 ,  G01N33/0063

Abstract: A zero-power digital chemical analyzer can include a chemically-selective percolation switch. The chemically selected percolation switch can include a positive electrode and a negative electrode separated from the positive electrode by a gap. A binding agent can be located at binding sites in the gap. The binding agent can be selective for binding to a target chemical compound. The binding sites can be distributed in the gap so that target chemical molecules binding to the binding sites can form an electrically conductive pathway via a natural percolation phenomenon between the electrodes when the ambient concentration of the target chemical compound reaches a threshold concentration.

公开(公告)号：US20180136189A1

公开(公告)日：2018-05-17

申请号：US15853888

申请日：2017-12-25

Applicant: Mohammad Abdolahad ,  Milad Gharooni ,  Shamsoddin Mohajerzadeh ,  Hamed Abiri ,  Mohsen Janmaleki

Inventor： Mohammad Abdolahad ,  Milad Gharooni ,  Shamsoddin Mohajerzadeh ,  Hamed Abiri ,  Mohsen Janmaleki

IPC: G01N33/483 ,  H01L21/02 ,  G01N27/02 ,  G01N33/574 ,  G01N33/50 ,  G01N27/327

CPC classification number: G01N33/4836 ,  G01N27/02 ,  G01N27/021 ,  G01N27/3278 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/574 ,  H01L21/02381 ,  H01L21/02488 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/02645 ,  H01L21/02653

Abstract: A method for detection and monitoring a therapeutic effect of a cancer treatment drug is disclosed. The method includes steps of removing a malignant biological cell lines from a tumor; culturing the removed biological cell lines in a controlled set of conditions; seeding the cultured biological cell lines on silicon nanowire electrode arrays of an electrical cell-substrate impedance sensor (ECIS); adding a cancer treatment drug to the seeded biological cell lines to treat the seeded biological cell lines; and measuring an electrical impedance of the treated biological cell lines for detection and monitoring a therapeutic effect of the cancer treatment drug.

公开(公告)号：US20180051311A1

公开(公告)日：2018-02-22

申请号：US15669069

申请日：2017-08-04

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Kamil Ekinci ,  Le Li ,  Chuanhua Duan ,  Vural Kara ,  Deborah Stearns-Kurosawa

IPC: C12Q1/18 ,  G01N33/487 ,  G01N27/02

CPC classification number: C12Q1/18 ,  B01L3/502761 ,  G01N27/021 ,  G01N33/48735

Abstract: A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing device includes at least one reservoir into which a bacteria solution is introduced and a microfluidic channel connected to the reservoir, wherein the cross-sectional size of the microfluidic channel is selected to be comparable to the size of the bacterium to be tested. Furthermore, the electrical resistance or voltage signal across the microchannel is monitored as bacteria swim into and out of the channel. Alternatively, a small population of bacteria can be immobilized in the microchannel. The resistance or voltage signal fluctuates when the bacteria are alive and moving in and out of the channel or wiggling on the microchannel walls. If the bacteria are dead, they have limited motility and the signal fluctuations are significantly smaller. By monitoring the signal fluctuations, the antibiotic susceptibility testing device can determine whether or not bacteria are alive, thus enabling antibiotic susceptibility testing of bacteria.

公开(公告)号：US09851343B2

公开(公告)日：2017-12-26

申请号：US15058922

申请日：2016-03-02

Applicant: Mohammad Abdolahad ,  Milad Gharooni ,  Shamsoddin Mohajerzadeh ,  Hamed Abiri ,  Mohsen Janmaleki

Inventor： Mohammad Abdolahad ,  Milad Gharooni ,  Shamsoddin Mohajerzadeh ,  Hamed Abiri ,  Mohsen Janmaleki

IPC: C12Q1/02 ,  G01N33/483 ,  H01L21/02 ,  G01N27/02 ,  G01N33/50 ,  G01N33/574 ,  G01N27/327

CPC classification number: G01N33/4836 ,  G01N27/02 ,  G01N27/021 ,  G01N27/3278 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/574 ,  H01L21/02381 ,  H01L21/02488 ,  H01L21/02532 ,  H01L21/02603 ,  H01L21/02645 ,  H01L21/02653

Abstract: A method for detection and monitoring a therapeutic effect of a cancer treatment drug is disclosed. The method includes steps of removing a malignant biological cell lines from a tumor; culturing the removed biological cell lines in a controlled set of conditions; seeding the cultured biological cell lines on silicon nanowire electrode arrays of an electrical cell-substrate impedance sensor (ECIS); adding a cancer treatment drug to the seeded biological cell lines to treat the seeded biological cell lines; and measuring an electrical impedance of the treated biological cell lines for detection and monitoring a therapeutic effect of the cancer treatment drug.

公开(公告)号：US09488635B2

公开(公告)日：2016-11-08

申请号：US13333124

申请日：2011-12-21

Applicant: Zongjin Li ,  Shengwen Tang ,  Youyuan Lu

Inventor： Zongjin Li ,  Shengwen Tang ,  Youyuan Lu

IPC: G01N33/38 ,  G01N27/02 ,  G01N27/04

CPC classification number: G01N33/383 ,  G01N27/021 ,  G01N27/048

Abstract: Measurement of the impedance and complex resistivity of a sample is used for measuring parameters resulting from a change in physical or chemical state. A variable frequency signal is provided by a transformer primary coil. A secondary coil of the transformer with a closed loop and electrically coupled said sample is monitored along with a leakage current sensor. Sampling at multiple signal frequencies is performed at the multiple signal frequencies.

Abstract translation: 样品的阻抗和复电阻率的测量用于测量由物理或化学状态的变化引起的参数。 可变频率信号由变压器初级线圈提供。 具有闭环和电耦合的所述样品的变压器的次级线圈与泄漏电流传感器一起被监测。 在多个信号频率下进行采样。

公开(公告)号：US09435788B2

公开(公告)日：2016-09-06

申请号：US14434257

申请日：2013-10-09

Applicant: Dublin City University

Inventor： Anthony Killard ,  Troy Hibbard ,  Karl Crowley

IPC: G01N33/497 ,  G01N27/02 ,  A61B5/08 ,  A61B5/097

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/097 ,  G01N27/021 ,  G01N2033/4975 ,  Y10T436/175383 ,  Y10T436/255 ,  Y10T436/25875

Abstract: A system for sensing and measuring ammonia in a breath sample is described. The system includes a sampling means for capturing and directing a breath sample from a subject to an ammonia sensor, the ammonia sensor including a conducting polymer polyaniline sensor. The sampling means includes a breath sample capture chamber, the chamber having an inlet and outlet, the inlet having a first valve through which a breath is exhaled into the sample capture chamber, the outlet having a second valve through which breath surplus to the volume of the chamber is expelled, to provide capture of a breath sample of predefined volume.

Abstract translation: 描述了用于感测和测量呼吸样品中的氨的系统。 该系统包括用于捕获并将呼吸样本从受试者引导到氨传感器的采样装置，氨传感器包括导电聚合物聚苯胺传感器。 采样装置包括呼吸样本捕获室，所述腔室具有入口和出口，所述入口具有第一阀，通过所述第一阀将呼吸呼出到所述样品捕获室中，所述出口具有第二阀，通过所述第二阀， 腔室被排出，以提供捕获预定体积的呼气样本。