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公开(公告)号：US3937635A
公开(公告)日：1976-02-10
申请号：US539731
申请日：1975-01-09
Applicant: Ralph T. Mead , Wilson Greatbatch
Inventor： Ralph T. Mead , Wilson Greatbatch
Abstract: A lithium-iodine cell including a lithium anode, a lithium iodine electrolyte and a cathode comprising a source of iodine in the form of a substantially solid block or pellet of iodine and iodine-containing depolarizer material applied in the form of a relatively thin layer or coating to a lithium surface of the anode and to a surface of the iodine block. The depolarizer material serves to transport iodine ions from the source to the electrolyte, and the material is a charge transfer complex of an organic donor component and iodine such as 2-vinyl pyridine iodide.
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公开(公告)号：US4203201A
公开(公告)日：1980-05-20
申请号：US921905
申请日：1978-07-05
Applicant: Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph , Norbert W. Frenz, Jr.
Inventor： Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph , Norbert W. Frenz, Jr.
CPC classification number: H01M2/1205 , H01M2/065 , H01M6/182 , Y10T29/49108 , Y10T29/4911
Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode is enclosed within an insulator element within the casing and a ferrule having one end within the insulator and the other end extending from the casing.
Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 阳极工作表面设置有有机电子给体材料的涂层。 阳极被封装在壳体内的绝缘体元件内，并且套管具有在绝缘体内的一端，另一端从壳体延伸。
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公开(公告)号：US4166158A
公开(公告)日：1979-08-28
申请号：US865849
申请日：1977-12-30
Applicant: Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
Inventor： Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
CPC classification number: H01M6/182 , H01M2/065 , Y10T29/49108
Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end within the insulator and the other end extending from the casing. During assembly, the cathode material is introduced in heated form and a filling element is employed which serves to keep the edge of the casing open end clean to facilitate subsequent welding of a lid to the casing.
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公开(公告)号：US4164070A
公开(公告)日：1979-08-14
申请号：US861527
申请日：1977-12-19
Applicant: Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
Inventor： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
CPC classification number: H01M6/182 , H01M2/065 , H01M4/60 , Y10T29/4911
Abstract: A lithium-bromine cell comprising a casing which can be of electrically conducting material and containing a lithium anode element from which a sealed conductor extends through the casing. A filling element which can be of electrically conducting material and which has a passage therethrough is fixed to the sealed casing with one end of the passage in communication with the interior of the casing and the other end externally exposed. Bromine is introduced through the passage to the interior of the casing into operative relationship with the lithium anode whereupon the passage is closed to complete the cell. The electrically conducting casing serves as a cathode current collector in operative contact with the bromine cathode, and after closing of the passage the electrically conducting filling element serves as an electrical terminal for the cell. An electrical potential difference exists between the terminal and the anode conductor during operation of the cell.
Abstract translation: 一种锂 - 溴电池，其包括可以是导电材料并且包含锂阳极元件的壳体，密封导体从该锂阳极元件穿过壳体。 可以是导电材料并且具有穿过其的通道的填充元件被固定到密封壳体，通道的一端与壳体的内部连通，另一端从外部暴露。 通过通向壳体内部的通道将溴引入与锂阳极的操作关系，由此通道封闭以完成电池。 导电壳体用作与溴阴极有效接触的阴极集电器，并且在通路关闭之后，导电填充元件用作电池的电端子。 在电池工作期间，端子和阳极导体之间存在电位差。
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公开(公告)号：US3994747A
公开(公告)日：1976-11-30
申请号：US617280
申请日：1975-09-29
Applicant: Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank Rudolph , Norbert W. Frenz
Inventor： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank Rudolph , Norbert W. Frenz
Abstract: A solid electrolyte primary cell comprising a lithium anode, a bromine cathode and a lithium bromide electrolyte. A solid lithium element operatively contacts the cathode material, and one form of cathode material is a charge transfer complex of an organic donor component material and bromine. The organic donor component material can be poly-2-vinyl pyridine. Another cathode material is liquid bromine. The surface of the lithium anode element which operatively contacts the cathode material can be provided with a coating of an organic electron donor component material. When the lithium anode operatively contacts the bromine cathode, a solid lithium bromide electrolyte begins to form at the interface and an electrical potential difference exists between conductors operatively connected to the anode and cathode.
Abstract translation: 一种固体电解质原电池，其包含锂阳极，溴阴极和溴化锂电解质。 固体锂元素可操作地接触阴极材料，并且一种形式的阴极材料是有机供体组分材料和溴的电荷转移络合物。 有机供体组分材料可以是聚-2-乙烯基吡啶。 另一种阴极材料是液态溴。 可操作地接触阴极材料的锂阳极元件的表面可以提供有机电子给体组分材料的涂层。 当锂阳极可操作地接触溴阴极时，固体溴化锂电解质开始在界面处形成，并且在可操作地连接到阳极和阴极的导体之间存在电势差。
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Patent Agency Ranking
公开(公告)号：US3944433A
公开(公告)日：1976-03-16
申请号：US539730
申请日：1975-01-09
Applicant: Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Inventor： Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Abstract: A lithium-iodine cell comprising a lithium anode and a cathode comprising an iodine element, a charge transfer complex of an organic donor component and iodine, and a cathode current collector operatively positioned between the iodine element and the charge transfer complex. The iodine element comprises a solid pellet of pure, non-conductive iodine, and the organic donor component of the charge transfer complex is two-vinyl pyridine polymer. The current collector is a screen or the equivalent which allows iodine to diffuse from the iodine element through the collector to the charge transfer complex. The iodine element is optimized for maximum iodine content without regard for conductivity, and the cathode material is optimized for maximum conductivity without regard for excess iodine content.
Abstract translation: 包含锂阳极和包含碘元素，有机供体组分的电荷转移络合物和碘的锂阳极和可操作地位于碘元素和电荷转移络合物之间的阴极集电器的锂碘电池。 碘元素包括纯的非导电碘的固体颗粒，电荷转移络合物的有机供体组分是双乙烯基吡啶聚合物。 集电器是屏幕或等效物，其允许碘从碘元素通过收集器扩散到电荷转移络合物。 碘元素针对最大碘含量进行了优化，而不考虑电导率，阴极材料针对最大导电率进行了优化，而不考虑过量的碘含量。
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公开(公告)号：US06988001B2
公开(公告)日：2006-01-17
申请号：US10283530
申请日：2002-10-30
Applicant: Wilson Greatbatch , Michael L. Weiner
Inventor： Wilson Greatbatch , Michael L. Weiner
IPC: A61N1/362
CPC classification number: A61N1/056 , A61N1/0565
Abstract: A hermetic component housing for use with a photonic catheter connected to a photonic pacemaker or other medical system designed for compatibility with Magnetic Resonance Imaging (MRI) procedures. The hermetic housing includes a housing body having a proximal end and a distal end. The body is formed with a hermetically sealed interior for carrying one or more electrical and/or optical components therein. The proximal end of the body is adapted to mount to a distal end of a photonic catheter carrying a fiber optic element or bundle. A hermetic terminal is provided to allow the fiber optic element or bundle to communicate with the body interior. The body can be adapted to mount (or function as) one or more electrodes designed for delivering or sensing electrical signals to body tissue, or it may be adapted to mount no electrodes. The component housing may be implemented by itself at the distal end of the photonic catheter, or it may be used in conjunction with other housings of like or different construction.
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公开(公告)号：US5324643A
公开(公告)日：1994-06-28
申请号：US739718
申请日：1991-07-29
Applicant: Wilson Greatbatch , John C. Sanford
Inventor： Wilson Greatbatch , John C. Sanford
IPC: A61K48/00 , C07K14/15 , C07K14/155 , C12N15/113 , C12N15/867 , C12N15/11 , C07H21/02 , C07H21/04 , C12N5/10
CPC classification number: C12N15/1131 , C07K14/005 , C12N15/1132 , C12N15/86 , A61K48/00 , C12N2740/13022 , C12N2740/13043 , C12N2740/15022 , C12N2740/16043
Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or homologous, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting retroviral replication and/or interfering with assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using cells upon which resistance to infection has been conferred.
Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，所述多核苷酸指导宿主细胞内的RNA，所述RNA是a）与取决于靶区域互补或同源的RNA与一个或多个核酸序列内的核酸序列 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，有效地抑制逆转录病毒复制和/或干扰组装成病毒颗粒。 还公开了使用其上赋予抗感染性的细胞的治疗方法。
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公开(公告)号：US4313438A
公开(公告)日：1982-02-02
申请号：US167752
申请日：1980-07-14
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: A method and apparatus for providing germicidal and healing treatment of tissue such as bone wherein an electrode of silver or like material is applied to a living tissue site to be healed, initially a direct voltage is applied to the electrode of a polarity driving the electrode as an anode to release silver ions to create a germicidal environment at the site, and thereafter a direct voltage of opposite polarity is applied to the electrode driving it as a cathode to stimulate healing of the tissue at the site. The apparatus is implanted in the body of a patient, and in one embodiment a battery is connected through a switch to the electrode and a reference electrode, the switch initially connecting the electrode as an anode and thereafter changeable by an external operator such as a magnet to connect the electrode as a cathode. In another embodiment, another electrode and an element cooperate with the treating electrode to form a galvanic couple with the treating electrode to create a germicidal environment and a predetermined time thereafter the arrangement changes to a biogalvanic couple with body fluid to cause healing of the tissue. In either embodiment a wave shaping circuit can be operatively associated with the treating electrode to facilitate external monitoring of the apparatus when implanted.
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公开(公告)号：US4157720A
公开(公告)日：1979-06-12
申请号：US833920
申请日：1977-09-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A61N1/375 , A61N1/3756
Abstract: A cardiac pacemaker including a pulse generator and an electrical source such as a battery completely enveloped in a small size housing. An electrode operatively connected to the pulse generator has a helically-shaped portion extending outwardly from the housing in fixed relation thereto. The housing is of sufficiently small size to permit the pacemaker to be implanted in conjunction with a limited thoracotomy by turning the housing to rotatively insert the electrode into the heart tissue of the patient, i.e. into the myocardium. The housing can be of electrically conducting material, insulated from the electrode, and a portion of the housing can serve as an indifferent electrode.
Abstract translation: 一种心脏起搏器，包括脉冲发生器和电源，例如完全包围在小尺寸壳体中的电池。 可操作地连接到脉冲发生器的电极具有螺旋状部分，其从壳体以固定关系向外延伸。 外壳的尺寸足够小以通过转动外壳将电极转移到患者的心脏组织，即心肌中，使起搏器能够与有限的开胸手术一起植入。 壳体可以是导电材料，与电极绝缘，并且壳体的一部分可以用作无关电极。
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