公开(公告)号：US20190160309A1

公开(公告)日：2019-05-30

申请号：US16202992

申请日：2018-11-28

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini ,  Dalong Liu ,  Hasan Aldiabat ,  Parker O'Brien

IPC: A61N7/00 ,  A61B8/00 ,  A61B8/14 ,  A61B8/08

Abstract: A dual-mode ultrasound system provides real-time imaging and therapy delivery using a transducer array. The system may use various imaging modes to provide image data that may be used to select control points within an imaging field of view. The control points along with the image data may be used to solve an optimization problem to achieve desired focusing gains at one or more of the control points. The optimized solution may be used to produce excitation waveforms to generate new image data. The focusing gains may be evaluated and the optimization problem may be iterated until desired focusing gains are achieved. Virtual arrays may be defined and cascaded to provide flexibility in solving the optimization problem.

公开(公告)号：US20230346354A1

公开(公告)日：2023-11-02

申请号：US18119039

申请日：2023-03-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini ,  Andrew J. Casper ,  Dalong Liu ,  John R. Ballard

IPC: A61B8/14 ,  A61B8/00 ,  A61N7/02 ,  A61B8/08 ,  G01S15/89 ,  G01S7/52

CPC classification number: A61B8/54 ,  A61B8/00 ,  A61B8/08 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/4438 ,  A61B8/4488 ,  A61B8/5207 ,  A61B8/5223 ,  A61N7/02 ,  G01S7/5202 ,  G01S7/52046 ,  G01S15/8915 ,  G01S15/8952 ,  G01S15/8959 ,  G01S15/8997 ,  A61B8/485 ,  A61N2007/0052

Abstract: A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multichannel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multimodal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

公开(公告)号：US20230293911A1

公开(公告)日：2023-09-21

申请号：US18117643

申请日：2023-03-06

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini

IPC: A61N7/00 ,  A61B8/00 ,  B06B1/06

CPC classification number: A61N7/00 ,  A61B8/4494 ,  B06B1/0688 ,  A61N2007/0086 ,  A61N2007/0052 ,  A61N2007/006 ,  A61N2007/0026

Abstract: An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count.

公开(公告)号：US11116474B2

公开(公告)日：2021-09-14

申请号：US14904568

申请日：2014-07-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini ,  Dalong Liu ,  Andrew J. Casper

IPC: A61B8/14 ,  A61B8/08 ,  A61N7/00 ,  G01S15/89 ,  G01S7/52 ,  A61B8/00

Abstract: Ultrasound adaptive imaging methods and/or systems provide for modification of waveform generation to drive a plurality of transducer elements. The modification may be based on at least one of contrast ratio or signal to noise ratio as determined with respect to control points in a region of interest. Further, image reconstruction may be performed upon separating, from pulse echo data received, at least a portion thereof received at each ultrasound transducer element from the region of interest in response to the delivered ultrasound energy corresponding to a single frequency of one or more image frequencies within a transducer apparatus bandwidth. The image reconstructed from the separated pulse-echo data corresponding to the single frequency of the one or more image frequencies may be used alone or combined with like image data (e.g., to provide an image representative of one or more properties in the region of interest).

公开(公告)号：US20190269385A1

公开(公告)日：2019-09-05

申请号：US16262138

申请日：2019-01-30

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini ,  Andrew J. Casper ,  Dalong Liu ,  John R. Ballard

IPC: A61B8/00 ,  A61B8/08 ,  A61N7/02

Abstract: A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multi-channel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multi-modal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data.

公开(公告)号：US20160143617A1

公开(公告)日：2016-05-26

申请号：US14904568

申请日：2014-07-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Emad S. Ebbini ,  Dalong Liu ,  Andrew J. Casper

IPC: A61B8/14 ,  A61N7/00 ,  A61B8/08

CPC classification number: A61B8/14 ,  A61B8/0891 ,  A61B8/4438 ,  A61B8/5207 ,  A61N7/00 ,  G01S7/5202 ,  G01S7/52046 ,  G01S15/8915 ,  G01S15/8952 ,  G01S15/8959 ,  G01S15/8997

Abstract: Ultrasound adaptive imaging methods and/or systems provide for modification of waveform generation to drive a plurality of transducer elements. The modification may be based on at least one of contrast ratio or signal to noise ratio as determined with respect to control points in a region of interest. Further, image reconstruction may be performed upon separating, from pulse echo data received, at least a portion thereof received at each ultrasound transducer element from the region of interest in response to the delivered ultrasound energy corresponding to a single frequency of one or more image frequencies within a transducer apparatus bandwidth. The image reconstructed from the separated pulse-echo data corresponding to the single frequency of the one or more image frequencies may be used alone or combined with like image data (e.g., to provide an image representative of one or more properties in the region of interest).

Abstract translation: 超声自适应成像方法和/或系统提供波形产生的修改以驱动多个换能器元件。 修改可以基于相对于感兴趣区域中的控制点确定的对比度比或信噪比中的至少一个。 此外，可以响应于对应于一个或多个图像频率的单个频率的递送的超声能量，从与所接收的脉冲回波数据分离其在每个超声换能器元件处的感兴趣区域的至少一部分，来执行图像重建 在换能器设备带宽内。 从与一个或多个图像频率的单个频率相对应的分离的脉冲 - 回波数据重建的图像可以单独使用或与相似的图像数据组合使用（例如，提供代表感兴趣区域中的一个或多个属性的图像 ）。