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    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
    11.
    发明申请
    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 审中-公开
    I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡

    公开(公告)号：US20060240036A1

    公开(公告)日：2006-10-26

    申请号：US11445311

    申请日：2006-06-02

    申请人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

    发明人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

    IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

    摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

    Death domain containing receptor 4
    13.
    发明申请
    Death domain containing receptor 4 有权
    死亡域含受体4

    公开(公告)号：US20050112090A9

    公开(公告)日：2005-05-26

    申请号：US10648786

    申请日：2003-08-27

    申请人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

    发明人： Jian Ni ,  Craig Rosen ,  Reiner Gentz

    IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  A61K38/19

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K39/39541 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/30 ,  C12N2799/026 ,  Y02A50/412 ,  A61K2300/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    Death domain containing receptor 5
    15.
    发明申请
    Death domain containing receptor 5 审中-公开
    含有受体5的死亡域

    公开(公告)号：US20050233958A1

    公开(公告)日：2005-10-20

    申请号：US10979831

    申请日：2004-11-03

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig Rosen

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig Rosen

    IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  C07K14/70578 ,  C07K2317/622 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。 本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。