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公开(公告)号：US11512987B2
公开(公告)日：2022-11-29
申请号：US17229457
申请日：2021-04-13
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates , Dean C. Richards , Scott Bendon
Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.
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公开(公告)号：US11384848B2
公开(公告)日：2022-07-12
申请号：US16994436
申请日：2020-08-14
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.
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13.发明授权公开(公告)号：US11112021B2
公开(公告)日：2021-09-07
申请号：US16794160
申请日：2020-02-18
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates , Scott Bendon
IPC: F16L3/26 , F16K27/00 , F16K7/07 , F16L3/24 , A61M5/14 , F16L3/13 , A23C7/00 , A61J3/00 , A61M39/28
Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.
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公开(公告)号：US11898645B2
公开(公告)日：2024-02-13
申请号：US16930300
申请日：2020-07-15
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates , Dean C. Richards , Scott Bendon
CPC classification number: F16K11/22 , B29C45/14614 , B29C66/01 , F16K7/06 , F16K7/07 , F16K27/003 , F16K27/0236 , F16B13/00
Abstract: A valve assembly with a multidirectional flow path includes a valve body that includes respective hinged portions defining respective passageways extending through the valve body when in a closed state. A flexible conduit or tubing having a loop portion and a plurality of branches extending from the loop portion is at least partially positioned within the valve body. Portions of the loop that extend beyond the valve body are encapsulated by respective rigid jackets. Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches. The valve assembly may be integrated into a manufacturing or other production process with optional additional jackets used to encapsulate the flexible conduit branches.
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公开(公告)号：US20230211292A1
公开(公告)日：2023-07-06
申请号：US18071899
申请日：2022-11-30
Applicant: Repligen Corporation
Inventor： Steven V. Cates , Rudolf Pavlik , Bao Le
CPC classification number: B01D61/18 , C12M47/02 , B01D61/145 , B01F27/851 , B01D2315/10 , B01D63/02
Abstract: Vessel configured to facilitate concentration of a product in a solution. The vessel may include outlet ports to deliver the solution to a processing system (such as a filtration system), and inlet ports. The inlet ports may be at progressively lower levels for return of fluid thereto reduced in volume as a result of filtration thereof. A smaller volume sump may be provided below a main tank of the vessel to facilitate concentration of the solution. The sump may include ridges facilitating collection of the product of interest from the solution, and/or reinforcing the sump walls, and optionally forming a vortex breaker. A spray ball may be provided to spray materials, such as buffer solution, into the vessel. The spray ball may direct materials to facilitate retrieval of product from the vessel. One or more components of the vessel may be advantageously formed of disposable material for single use thereof.
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Patent Agency Ranking
公开(公告)号：US20220356955A1
公开(公告)日：2022-11-10
申请号：US17869031
申请日：2022-07-20
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.
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公开(公告)号：US20220356954A1
公开(公告)日：2022-11-10
申请号：US17869009
申请日：2022-07-20
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates
Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.
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公开(公告)号：US20220196162A1
公开(公告)日：2022-06-23
申请号：US17690169
申请日：2022-03-09
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Steven V. Cates
Abstract: An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.
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公开(公告)号：US11274954B2
公开(公告)日：2022-03-15
申请号：US16718084
申请日：2019-12-17
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: A method of using a fluid monitoring assembly for measuring the flow rate of a fluid through a flexible conduit comprising a wall that defines a lumen through which the fluid passes. The assembly includes a housing having first and second portions each defining respective recessed interior portions that define a cavity that is configured to encapsulate and retain the flow sensor and the flexible tubing contained therein. The flow sensor may be removably secured around the outside of the flexible conduit and include one or more transducer/receiver pairs.
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公开(公告)号：US20220299121A1
公开(公告)日：2022-09-22
申请号：US17835166
申请日：2022-06-08
Applicant: Repligen Corporation
Inventor： Michael C. Gagne , Dean C. Richards , Steven V. Cates
Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.
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