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公开(公告)号：US5725860A
公开(公告)日：1998-03-10
申请号：US687518
申请日：1996-08-07
CPC分类号： A61K38/28 , A61K39/0008 , A61K39/39 , A61K2039/55544 , A61K2039/55594
摘要： The incidence of the autoimmune disease, diabetes mellitus, is well controlled in the nude-obese-diabetic (NOD) mouse model using injections of the A chain fragment (or parts thereof) of the insulin molecule as an antigen in combination with killed cells (or parts thereof) of Haemophilus pertussis, acting as an adjuvant. This leads to the convenient prevention of diabetes in humans using the common "Triple vaccine" (DPT) diphtheria/whooping cough/tetanus vaccine (or versions thereof) in combination with A chain fragment of insulin. This mixture can be given to an at-risk population in which diabetes is expected to occur at an abnormally high rate, or it can be given to the entire population.
摘要翻译： PCT No.PCT / NZ95 / 00025 Sec。 371日期：1996年8月7日 102（e）日期1996年8月7日PCT Filed Mar. 6，1995 PCT Pub。 出版物WO95 / 24216 PCT 日期1995年9月14日自身免疫性疾病，糖尿病的发病率在裸鼠肥胖 - 糖尿病（NOD）小鼠模型中得到很好的控制，使用胰岛素分子的A链片段（或其部分）作为抗原进行注射 与作为佐剂的百日咳嗜血杆菌的杀死细胞（或其部分）组合。 这导致使用普通的“三联疫苗”（DPT）白喉/百日咳/破伤风疫苗（或其版本）与胰岛素的A链片段组合来方便地预防人体中的糖尿病。 这种混合物可以被给予预期以异常高的速率发生糖尿病的高危人群，或者可以给予整个人群。
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公开(公告)号：US20100130406A1
公开(公告)日：2010-05-27
申请号：US12597421
申请日：2008-04-24
CPC分类号： A61K35/20 , A23C9/20 , A23K20/147 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/018 , A23V2200/322 , A23V2250/54246
摘要： Milk-based products and drinks are provided including specified forms of identified proteins or fragments thereof, as are methods for the use of such milk-based products and drinks in the promotion of sleep.
摘要翻译： 提供基于乳的产品和饮料，包括确定的蛋白质或其片段的特定形式，以及在促进睡眠中使用这种基于乳的产品和饮料的方法。
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公开(公告)号：US20090181064A1
公开(公告)日：2009-07-16
申请号：US12398642
申请日：2009-03-05
CPC分类号： A61L27/3821 , A61K35/12 , A61K35/30 , A61K2035/128 , A61L27/3813 , A61L27/383 , A61L27/3878 , C12N5/0618 , C12N5/069
摘要： A “supplementary choroid plexus” comprising preferably a xenotransplant of choroid plexus cells from a neonatal mammal provides a steady supply of trophic factors for administration to a central nervous system in need of treatment for a neurological disease. Choroid plexus cells manufacture a range of trophic factors, particularly during fetal development. This neurotrophic factor therapy may be useful in treating clinical and subclinical neurodegenerative diseases particularly those in which the choroid plexus has often become atrophic. The xenotransplant is cloaked in a protective layer (such as of alginate) capable of concealing the foreign nature of the transplant. Lateral ventricles are the preferred implantation site, from where the trophic factors are carried through the neuropil by the circulation of cerebrospinal fluid.
摘要翻译： 优选地包含来自新生儿哺乳动物的脉络丛神经细胞的异种移植物的“补充性脉络丛”为营养因子提供了稳定的供给给需要治疗神经疾病的中枢神经系统的营养因子。 脉络丛细胞产生一系列营养因子，特别是在胎儿发育过程中。 这种神经营养因子治疗可用于治疗临床和亚临床神经变性疾病，特别是其中脉络丛经常萎缩的疾病。 异种移植物被掩盖在能够隐藏移植物的外来性质的保护层（例如藻酸盐）中。 侧脑室是优选的植入部位，营养因子由脑脊液循环通过神经纤维运送。
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公开(公告)号：US20080292611A1
公开(公告)日：2008-11-27
申请号：US12146895
申请日：2008-06-26
CPC分类号： A61K9/5036 , A61K9/0019 , A61K9/5073 , A61K35/42 , A61K38/4886 , A61K48/0075 , C12Y304/24017 , A61K2300/00
摘要： The invention relates to a novel method of administration, and device employed in the method, for administering a treatment species to the lungs of a recipient patient. The method involves introducing the device of the invention to the venous system of the patient, the size of the treatment species being such that, upon introduction to the venous system of the patient, the device will impact in a region of a lung capillary of the patient. The treatment species gains access to the lung and/or lung epithelia due to proteases associated with the treatments species. The application of the method to the treatment of cystic fibrosis is also claimed.
摘要翻译： 本发明涉及一种新的给药方法和该方法中使用的装置，用于将受治疗物种给予接受者患者的肺。 该方法包括将本发明的装置引入到患者的静脉系统中，治疗种类的大小使得在引入患者的静脉系统时，该装置将影响患者的肺毛细血管区域 患者。 由于与处理物种相关的蛋白酶，处理物种获得进入肺和/或肺上皮细胞的能力。 还要求使用该方法治疗囊性纤维化。
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公开(公告)号：US20080286864A1
公开(公告)日：2008-11-20
申请号：US11911961
申请日：2006-04-18
申请人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
发明人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
IPC分类号： C12N5/02
CPC分类号： C12N5/0018 , C12N2502/08
摘要： The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.
摘要翻译： 本发明涉及脉络丛神经细胞和/或脉络丛条件培养基用于增强长期或短期培养中生长的非脉络丛神经细胞的生长，存活和/或维持功能的用途。
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公开(公告)号：US20090075375A1
公开(公告)日：2009-03-19
申请号：US12210696
申请日：2008-09-15
申请人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos , Thorsten Gorba
发明人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos , Thorsten Gorba
IPC分类号： C12N5/06
CPC分类号： C12N5/0018 , C12N2502/08
摘要： The present invention is directed to the use of choroids plexus cells and/or choroids plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.
摘要翻译： 本发明涉及脉络丛细胞和/或脉络丛丛状培养基用于增强长期或短期培养中生长的非脉络丛神经细胞的生长，存活和/或维持功能的用途。
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17.发明申请公开(公告)号：US20080254090A1
公开(公告)日：2008-10-16
申请号：US10562246
申请日：2004-06-24
CPC分类号： A61K35/39 , A61K35/12 , C12N5/0676 , C12N5/0677 , C12N2502/246 , C12N2510/02
摘要： Aggregates and their method of preparation suitable for implantation into a recipient in order to produce insulin in vivo. The methods involve culturing islet cells isolated from the pancreas of donor piglets with isolated Sertoli cells from the testes of donor piglets. A preferred period of culturing is 5 days and may be followed by a purification procedure.
摘要翻译： 聚集体及其制备方法适于植入受体以在体内产生胰岛素。 该方法包括培养从供体仔猪胰腺分离的胰岛细胞，并从供体仔猪的睾丸中分离出Sertoli细胞。 优选的培养时间为5天，然后进行纯化程序。
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公开(公告)号：US07323323B2
公开(公告)日：2008-01-29
申请号：US10443344
申请日：2003-05-22
IPC分类号： C12N11/04
CPC分类号： C12N5/0677 , A61K35/12 , A61K2035/128 , C12N2500/38 , C12N2501/998 , C12N2501/999 , C12N2509/00
摘要： The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of: (I) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide. Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.
摘要翻译： 本发明涉及哺乳动物糖尿病治疗的发展。 特别地涉及一种制备能够在合适的受体哺乳动物中异种移植产生猪胰岛素的异种移植的猪胰岛制剂的方法，所述方法包括或包括以下步骤：（I）在全期妊娠或接近全期妊娠收获仔猪的胰腺， 和（ii）从收获的胰腺中提取胰岛β岛细胞，其中胰岛（至少在该方法的某一阶段）暴露于烟酰胺。 此外，本发明涉及一种非异种移植的猪胰岛制剂的包封方法，以及将这种制剂或含有这种制剂的胶囊移植到合适的受体哺乳动物中。
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