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17 条记录 (耗时 0.04 秒)

    4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same
    14.
    发明授权
    4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same 有权
    4-（3-氯-2-氟苯胺基）-7-甲氧基-6 - {[1-（N-甲基氨基甲酰基 - 甲基）哌啶-4-基]氧基}喹唑啉，其药学上可接受的盐和包含它们的药物组合物

    公开(公告)号：US08318752B2

    公开(公告)日：2012-11-27

    申请号：US10571991

    申请日：2004-09-15

    申请人： Bernard Barlaam

    发明人： Bernard Barlaam

    IPC分类号： A61K31/517

    CPC分类号： C04B35/632 ,  C07D401/12

    摘要： The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物：其中R1，X1，R2，R3，R5，n和m各自具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对EGF和erbB受体酪氨酸激酶的抑制敏感的肿瘤中作为抗增殖剂的药物中的用途。

    Selective estrogen receptor-β ligands
    16.
    发明授权
    Selective estrogen receptor-β ligands 失效
    选择性雌激素受体-β配体

    公开(公告)号：US07256201B2

    公开(公告)日：2007-08-14

    申请号：US10450023

    申请日：2001-12-07

    申请人： Bernard Barlaam ,  Cathy Dantzman

    发明人： Bernard Barlaam ,  Cathy Dantzman

    IPC分类号： C07D217/02 ,  A61K31/47

    CPC分类号： C07D209/44 ,  C07D217/04 ,  C07D217/06 ,  C07D217/14 ,  C07D405/04 ,  C07D409/04

    摘要： The invention relates to novel compounds having the general formula: (I) and arc useful as selective ER-β ligands in the treatment or prophylaxis of Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis cardiovascular disease, rheumatoid arthritis or prostate cancer.

    摘要翻译： 本发明涉及具有以下通式的新化合物：（I）和弧用作治疗或预防阿尔茨海默氏病，焦虑障碍，抑郁障碍，骨质疏松性心血管疾病，类风湿性关节炎或前列腺癌的选择性ER-β配体。