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17 条记录 (耗时 0.02 秒)

    NOVEL COMPOUNDS
    1.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：US20090131463A1

    公开(公告)日：2009-05-21

    申请号：US12359541

    申请日：2009-01-26

    申请人： Bernard Barlaam ,  Andrew Pape ,  Andrew Thomas

    发明人： Bernard Barlaam ,  Andrew Pape ,  Andrew Thomas

    IPC分类号： A61K31/506 ,  C07D401/02 ,  A61P35/00

    CPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

    摘要： The invention provides compounds of formula in which R1, R2, R3 and R4 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

    摘要翻译： 本发明提供式R1化合物，其中R1，R2，R3和R4具有本说明书中定义的含义; 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。

    Therapeutic benzoxazole compounds
    5.
    发明授权
    Therapeutic benzoxazole compounds 失效
    治疗性苯并恶唑化合物

    公开(公告)号：US07045539B2

    公开(公告)日：2006-05-16

    申请号：US10450927

    申请日：2001-12-19

    申请人： Bernard Barlaam ,  Peter Bernstein ,  Cathy Dantzman ,  Paul Warwick

    发明人： Bernard Barlaam ,  Peter Bernstein ,  Cathy Dantzman ,  Paul Warwick

    IPC分类号： A61K31/425 ,  C07D277/62 ,  A61P25/00

    CPC分类号： C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D417/04

    摘要： Compounds of the formula (I) for use as an estrogen receptor-β-selective ligand are described wherein: X is O or S; and R1, R3 R6 are as described in the specification. The use of these compounds in treating Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis, cardiovascular disease, rheumatoid arthritis and prostate cancer is described; as are processes for making them.

    摘要翻译： 描述了用作雌激素受体-β-选择性配体的式（I）化合物，其中：X为O或S; 和R 1，R 3，R 6和S 6如说明书中所述。 描述了这些化合物在治疗阿尔茨海默病，焦虑障碍，抑郁障碍，骨质疏松症，心血管疾病，类风湿性关节炎和前列腺癌中的用途。 制作它们的过程也是如此。

    Therapeutic benzothiazole compounds
    7.
    发明申请
    Therapeutic benzothiazole compounds 审中-公开
    治疗性苯并噻唑化合物

    公开(公告)号：US20060111408A1

    公开(公告)日：2006-05-25

    申请号：US11246663

    申请日：2006-01-03

    申请人： Bernard Barlaam ,  Peter Bernstein ,  Cathy Dantzman ,  Paul Warwick

    发明人： Bernard Barlaam ,  Peter Bernstein ,  Cathy Dantzman ,  Paul Warwick

    IPC分类号： A61K31/428 ,  C07D417/02 ,  C07D277/60

    CPC分类号： C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D417/04

    摘要： Compounds of the formula (I) for use as an estrogen receptor -β-selective ligand are described wherein: X is O or S; and R1, R3-R6 are as described in the specification. The use of these compounds in treating Alzheimer's disease, anxiety disorders, depressive disorders, osteoporosis, cardiovascular disease, rheumatoid arthritis and prostate cancer is described; as are processes for making them.

    摘要翻译： 描述了用作雌激素受体 - 选择性配体的式（I）化合物，其中：X为O或S; R 1，R 3，R 6和R 6如说明书中所述。 描述了这些化合物在治疗阿尔茨海默病，焦虑障碍，抑郁障碍，骨质疏松症，心血管疾病，类风湿性关节炎和前列腺癌中的用途。 制作它们的过程也是如此。

    4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same
    9.
    发明授权
    4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same 有权
    4-（3-氯-2-氟苯胺基）-7-甲氧基-6 - {[1-（N-甲基氨基甲酰基 - 甲基）哌啶-4-基]氧基}喹唑啉，其药学上可接受的盐和包含它们的药物组合物

    公开(公告)号：US08318752B2

    公开(公告)日：2012-11-27

    申请号：US10571991

    申请日：2004-09-15

    申请人： Bernard Barlaam

    发明人： Bernard Barlaam

    IPC分类号： A61K31/517

    CPC分类号： C04B35/632 ,  C07D401/12

    摘要： The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.

    摘要翻译： 本发明涉及式（I）的喹唑啉衍生物：其中R1，X1，R2，R3，R5，n和m各自具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对EGF和erbB受体酪氨酸激酶的抑制敏感的肿瘤中作为抗增殖剂的药物中的用途。