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公开(公告)号：US07805978B2
公开(公告)日：2010-10-05
申请号：US11876692
申请日：2007-10-22
IPC分类号： G01N29/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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公开(公告)号：US07726174B2
公开(公告)日：2010-06-01
申请号：US11876609
申请日：2007-10-22
IPC分类号： G01N29/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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13.发明授权Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages 失效具有与非膦酸酯核苷间键合混合的具有手性纯的磷酸酯核苷间键的合成低聚物
公开(公告)号：US5792615A
公开(公告)日：1998-08-11
申请号：US812861
申请日：1997-03-06
申请人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
发明人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
摘要： Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
摘要翻译： 提供了具有与RNA靶序列杂交的非膦酸酯核苷间键的手性纯膦酸核苷间键的寡聚物及其制备方法。
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公开(公告)号：US09433684B2
公开(公告)日：2016-09-06
申请号：US12737833
申请日：2009-08-19
申请人： Samuel P. McManus , Timothy A. Riley , Sean M. Culbertson , Antoni Kozlowski , Dennis G. Fry , Xuejun Yuan , Dawei Sheng , Vidula R. Dixit
发明人： Samuel P. McManus , Timothy A. Riley , Sean M. Culbertson , Antoni Kozlowski , Dennis G. Fry , Xuejun Yuan , Dawei Sheng , Vidula R. Dixit
IPC分类号： C12Q1/68 , C12N15/11 , A61K47/48 , C08G65/329
CPC分类号： A61K47/48215 , A61K47/549 , A61K47/60 , A61K47/61 , A61K47/64 , C08G65/329 , C08L2203/02
摘要： The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
摘要翻译： 本发明涉及小干扰核酸（siNA）的结合物。 描述适合于给予患者的siNA的组合物。 还描述了递送组合物的方法。
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公开(公告)号：US09006219B2
公开(公告)日：2015-04-14
申请号：US12921697
申请日：2009-03-12
申请人： Timothy A. Riley , Lin Cheng
发明人： Timothy A. Riley , Lin Cheng
IPC分类号： A61K31/662 , C07F9/38 , C07F9/40 , A61P31/18 , A61K47/48
CPC分类号： A61K31/662 , A61K47/60 , C07F9/40 , C08G65/3355 , C08G2650/02 , C08G2650/04 , C08G2650/38
摘要： The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
摘要翻译： 本发明涉及（尤其）低聚物 - 膦甲酸共轭物和相关化合物。 当通过任何多种施用途径给药时，本发明的缀合物显示出优于先前施用的未缀合的膦甲酸酯化合物的优点。
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公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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17.发明授权Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 有权寡核苷酸探针和引物包含用于诊断目的的通用碱基公开(公告)号：US08153772B2
公开(公告)日：2012-04-10
申请号：US10375504
申请日：2003-02-25
申请人： Bob D. Brown , Timothy A. Riley
发明人： Bob D. Brown , Timothy A. Riley
CPC分类号： C07H21/04 , C07H21/00 , C12N15/1034 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/12 , C12N2310/31 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/351 , C12N2310/3533 , C12Q1/6883 , C12Q2600/156 , C12N2310/3521
摘要： Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease.
摘要翻译： 本发明的方面涉及包含用作引物和探针的通用碱基和通用碱基的新型寡核苷酸，以及使用所述寡核苷酸进行疾病诊断的方法。
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公开(公告)号：US20110105438A1
公开(公告)日：2011-05-05
申请号：US12921697
申请日：2009-03-12
申请人： Timothy A. Riley , Lin Cheng
发明人： Timothy A. Riley , Lin Cheng
IPC分类号： A61K31/662 , C07F9/38 , C07F9/40 , A61P31/18
CPC分类号： A61K31/662 , A61K47/60 , C07F9/40 , C08G65/3355 , C08G2650/02 , C08G2650/04 , C08G2650/38
摘要： The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
摘要翻译： 本发明涉及（尤其）低聚物 - 膦甲酸共轭物和相关化合物。 当通过任何多种施用途径给药时，本发明的缀合物显示出优于先前施用的未缀合的膦甲酸酯化合物的优点。
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公开(公告)号：US20100306986A1
公开(公告)日：2010-12-09
申请号：US12856447
申请日：2010-08-13
IPC分类号： B23P11/00
CPC分类号： G01N29/02 , A61M1/3626 , A61M5/365 , A61M2205/3375 , G01N29/032 , G01N29/221 , G01N29/222 , G01N29/2468 , G01N2291/02433 , G01N2291/02854 , G01N2291/048 , Y10T29/42 , Y10T29/49005 , Y10T29/4908 , Y10T29/4979 , Y10T29/49826
摘要： A universal air bubble detector allows for use with a variety of sizes and types of tubing. The detector maintains proper alignment of a sensor emitter and receiver with different sizes of tubing. The detector may be mounted on existing equipment or may be used to monitor a tubing at any position along the tubing, and may operate in a stand alone mode or in combination with existing equipment.
摘要翻译： 通用气泡检测器可用于各种尺寸和类型的管道。 检测器保持传感器发射器和接收器与不同尺寸的管道的正确对准。 检测器可以安装在现有的设备上，或者可以用于在沿着管道的任何位置处监测管道，并且可以以独立模式运行或者与现有设备组合。
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公开(公告)号：US5837856A
公开(公告)日：1998-11-17
申请号：US814053
申请日：1997-03-06
IPC分类号： C12N15/09 , A61K31/70 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1131 , C07H21/00
摘要： Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.
摘要翻译： 提供了具有与RNA靶序列杂交的预选手性的富含膦酸酯键合的膦酸酯核苷间键的低聚物及其制备方法。
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