-
1.发明授权Synthetic oligomers having chirally pure phoshonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages 失效具有与非膦酸酯核苷间键合混合的具有手性纯的磷酸酯核苷间键的合成低聚物
公开(公告)号：US5792615A
公开(公告)日：1998-08-11
申请号：US812861
申请日：1997-03-06
申请人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
发明人： Lyle J. Arnold, Jr. , Richard I. Hogrefe , Mark A. Reynolds , Timothy A. Riley , David A. Schwartz
摘要： Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.
摘要翻译： 提供了具有与RNA靶序列杂交的非膦酸酯核苷间键的手性纯膦酸核苷间键的寡聚物及其制备方法。
-
公开(公告)号：US07732628B2
公开(公告)日：2010-06-08
申请号：US10936751
申请日：2004-09-08
IPC分类号： C07F9/02
CPC分类号： C08G65/329 , A61K47/61 , A61K47/62 , A61K47/643 , A61K47/645 , A61K47/6801 , C04B35/632 , C07D207/452 , C07D207/46 , C07D213/82 , C07D401/12 , C07F7/1804 , C07F9/2408 , C07F9/58 , C07H21/00
摘要： Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供肼基，氧基氨基和羰基试剂以及在其固相合成期间掺入寡核苷酸的方法。 提供了掺入本文提供的试剂的修饰的寡核苷酸。 提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：US07999098B2
公开(公告)日：2011-08-16
申请号：US11638062
申请日：2006-12-11
IPC分类号： C07H21/00
摘要： Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供了肼基，氧基氨基和羰基单体以及在酶合成期间掺入寡核苷酸的方法。 提供了引入本文提供的单体的修饰的寡核苷酸。 提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：US07102024B1
公开(公告)日：2006-09-05
申请号：US09630060
申请日：2000-08-01
CPC分类号： C08G65/329 , A61K47/61 , A61K47/62 , A61K47/643 , A61K47/645 , A61K47/6801 , C04B35/632 , C07D207/452 , C07D207/46 , C07D213/82 , C07D401/12 , C07F7/1804 , C07F9/2408 , C07F9/58 , C07H21/00
摘要： Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供肼基，氧基氨基和羰基试剂以及在其固相合成期间掺入寡核苷酸的方法。 提供了掺入本文提供的试剂的修饰的寡核苷酸。提供了含有共价腙或肟键的固定的寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：US06686461B1
公开(公告)日：2004-02-03
申请号：US09630627
申请日：2000-08-01
IPC分类号： C07H1904
摘要： Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供了肼基，氧基氨基和羰基单体以及在酶合成期间掺入寡核苷酸的方法。 提供了引入本文提供的单体的修饰的寡核苷酸。 提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：USRE46171E1
公开(公告)日：2016-10-04
申请号：US13491563
申请日：2012-06-07
IPC分类号： C07F9/02 , A61K47/48 , C04B35/632 , C07D207/46 , C07D207/452 , C07D213/82 , C07D401/12 , C07F7/18 , C07F9/24 , C07F9/58 , C07H21/00
CPC分类号： C08G65/329 , A61K47/61 , A61K47/62 , A61K47/643 , A61K47/645 , A61K47/6801 , C04B35/632 , C07D207/452 , C07D207/46 , C07D213/82 , C07D401/12 , C07F7/1804 , C07F9/2408 , C07F9/58 , C07H21/00
摘要： Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供肼基，氧基氨基和羰基试剂以及在其固相合成期间掺入寡核苷酸的方法。 提供了掺入本文提供的试剂的修饰的寡核苷酸。 提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：US07173125B2
公开(公告)日：2007-02-06
申请号：US10720840
申请日：2003-11-24
摘要： Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译： 提供了肼基，氧基氨基和羰基单体以及在酶合成期间掺入寡核苷酸的方法。 提供了引入本文提供的单体的修饰的寡核苷酸。 提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。 提供了制备表面结合寡核苷酸的方法。 还提供了制备寡核苷酸缀合物的方法。
-
公开(公告)号：US06320041B1
公开(公告)日：2001-11-20
申请号：US09834828
申请日：2001-04-13
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07B2200/11 , C07F9/2408 , C07F9/4883 , C07F9/5537 , C07F9/65188 , C07H19/10
摘要： The present invention provides a variety of compositions that comprise an activated carboxylic ester moiety on one end of an alkyl tether and a nucleic acid binding moiety on the other end for use as crosslinking reagents in conjugation reactions of nucleotides with solid support matrixes, organic molecules, reporter groups or other biomolecules.
摘要翻译： 本发明提供了多种组合物，其包含在烷基系链的一端上的活化羧酸酯部分和另一端的核酸结合部分，用作核苷酸与固体支持基质，有机分子的缀合反应中的交联试剂， 记者组或其他生物分子。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.035 秒)
