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公开(公告)号：US20060252758A1
公开(公告)日：2006-11-09
申请号：US11402200
申请日：2006-04-11
申请人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
IPC分类号： A61K31/519 , A61K31/4747 , A61K31/407 , C07D498/14 , C07D487/14
CPC分类号： C07D491/22 , C07D495/22
摘要： This invention is directed to spiroheterocyclic compounds of formula (I) wherein k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明涉及式（I）的螺杂环化合物，其中k，j，p，Q，R 1，R 3a，R 3b， 作为其立体异构体，对映异构体，互变异构体或其混合物; R 3，R 3，R 3和R 3如本文所定义。 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含该化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US07112222B2
公开(公告)日：2006-09-26
申请号：US10403930
申请日：2003-03-31
IPC分类号： A61F2/44
CPC分类号： A61B17/8047 , A61B17/7059 , A61F2/4455 , A61F2002/30331 , A61F2002/30504 , A61F2002/30563 , A61F2002/30578 , A61F2002/30604 , A61F2002/30904 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033
摘要： A spinal fixation assembly is provided including a fusion cage with posterior, anterior, superior, and inferior faces, and a plate having at least one aperture for receiving a bone screw and having a mating element adapted to slidably engage and mate to the anterior face of the fusion cage. The cage is adapted to be positioned between adjacent vertebrae, and the plate is effective to mate to the cage and to receive one or more bone screws to fasten the plate and secure the fusion cage to the adjacent vertebrae.
摘要翻译： 提供脊柱固定组件，其包括具有后部，前部，上部和下部面的融合器，以及具有至少一个用于接收骨螺钉的孔的板，并且具有适于可滑动地接合并配合到 融合笼。 笼子适于定位在相邻的椎骨之间，并且板有效地与笼子配合并且接收一个或多个骨螺钉以固定板并将融合器固定到相邻的椎骨。
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13.发明申请公开(公告)号：US20120122909A9
公开(公告)日：2012-05-17
申请号：US13078678
申请日：2011-04-01
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Ralna , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Ralna , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/4747 , A61K31/407 , A61P25/24 , A61P25/04 , A61P9/00 , A61P11/00 , A61P25/18 , A61P29/00 , A61P25/06 , A61P25/00 , A61P43/00 , A61P25/22 , A61P9/10 , A61P19/02 , A61P35/00 , A61P25/08 , A61P9/06 , C07D491/20
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义，作为立体异构体， 其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含化合物的药物组合物以及制备和使用化合物的方法。
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公开(公告)号：US20120035199A9
公开(公告)日：2012-02-09
申请号：US12855514
申请日：2010-08-12
申请人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
IPC分类号： A61K31/438 , C07D495/22 , A61K31/407 , A61P29/00 , A61P25/04 , A61P9/00 , A61P11/00 , A61P25/00 , A61P25/06 , C07D491/22 , A61P25/24
CPC分类号： C07D491/22 , C07D495/22
摘要： This invention is directed to spiroheterocyclic compounds of formula (I): wherein k, j, p, Q, R1, R3a, R3b, R3e, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明涉及式（I）的螺杂环化合物：其中k，j，p，Q，R1，R3a，R3b，R3e和R3d如本文所定义，作为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂化物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含该化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US08106087B2
公开(公告)日：2012-01-31
申请号：US12650196
申请日：2009-12-30
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/407 , A61K31/5377
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义，作为立体异构体， 其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含化合物的药物组合物以及制备和使用化合物的方法。
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公开(公告)号：US20110172282A9
公开(公告)日：2011-07-14
申请号：US12445264
申请日：2007-10-12
申请人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
发明人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
IPC分类号： A61K31/404 , A61P9/10 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
摘要翻译： 本发明涉及使用式（I）的螺 - 羟吲哚化合物的方法：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义， 立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗和/或预防高胆固醇血症，良性前列腺增生，瘙痒症和癌症。
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公开(公告)号：US20110004253A1
公开(公告)日：2011-01-06
申请号：US12883832
申请日：2010-09-16
IPC分类号： A61B17/88
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/86 , A61B2017/564 , A61B2017/681 , A61F2/4455 , A61F2002/30228 , A61F2002/30331 , A61F2002/30504 , A61F2002/30563 , A61F2002/30578 , A61F2002/30604 , A61F2002/30904 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033
摘要： Spinal fixation plates for maintaining adjacent vertebrae in and fixed position are provided. In an exemplary embodiment, the plate includes opposed superior and inferior portions that are angled in a direction anterior to an anterior face of a mid-portion of the plate. The plate also includes a curvature formed therein about a longitudinal axis in a sagittal plane thereof. In use, when the plate is attached to adjacent vertebrae, the angle of the superior and inferior portions and the curvature in the plate are effective to position one or more thru-bores formed in the superior and inferior portions at the anterior rims of the adjacent vertebrae. In another embodiment, a spinal fixation plate is provided that is adapted to engage and mate to a fusion cage or other vertebral implant disposed between adjacent vertebra. The present invention also provides spinal fixation kits or assemblies, and methods for implanting the same.
摘要翻译： 提供用于将相邻椎骨保持在固定位置的脊椎固定板。 在一个示例性实施例中，板包括相对的上部和下部，其在板的中间部分的前表面的前方的方向成角度。 该板还包括围绕其矢状平面中的纵向轴线形成的曲率。 在使用中，当板附接到相邻的椎骨时，上部和下部的角度和板中的曲率有效地将形成在上部和下部的一个或多个穿孔定位在相邻的前边缘 椎骨 在另一个实施例中，提供脊柱固定板，其适于接合并配合到设置在相邻椎骨之间的融合笼或其它椎骨植入物。 本发明还提供了脊柱固定套件或组件，以及用于植入它们的方法。
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18.发明申请公开(公告)号：US20100130487A1
公开(公告)日：2010-05-27
申请号：US12650218
申请日：2009-12-30
申请人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
发明人： Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
IPC分类号： A61K31/407 , C07D491/20 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61P25/24 , A61P9/00 , A61P11/00 , A61P25/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
摘要翻译： 本发明涉及式（I）的螺 - 羟吲哚化合物：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义，作为立体异构体， 其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，其可用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。 还公开了包含化合物的药物组合物以及制备和使用化合物的方法。
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公开(公告)号：US06432106B1
公开(公告)日：2002-08-13
申请号：US09449105
申请日：1999-11-24
申请人： Robert Fraser
发明人： Robert Fraser
IPC分类号： A61B1770
CPC分类号： A61F2/30771 , A61B17/7059 , A61B17/80 , A61B17/86 , A61F2/30965 , A61F2/442 , A61F2/4465 , A61F2/4611 , A61F2002/2835 , A61F2002/30112 , A61F2002/30187 , A61F2002/3023 , A61F2002/30329 , A61F2002/30387 , A61F2002/30398 , A61F2002/30578 , A61F2002/30604 , A61F2002/30774 , A61F2002/30787 , A61F2002/30841 , A61F2002/30848 , A61F2002/30892 , A61F2002/4475 , A61F2220/0025 , A61F2230/0004 , A61F2230/0034 , A61F2230/0069 , A61F2310/00023
摘要： A spinal fixation assembly includes a fusion cage to which a plate is mated. The plate is configured to receive, retain and orient bone screws.
摘要翻译： 脊柱固定组件包括与板相配合的融合笼。 板被配置为接收，保持和定向骨螺钉。
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公开(公告)号：US08466188B2
公开(公告)日：2013-06-18
申请号：US12445264
申请日：2007-10-12
申请人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
发明人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
IPC分类号： A61K31/40 , A61K31/5377
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
摘要翻译： 本发明涉及使用式（I）的螺 - 羟吲哚化合物的方法：其中k，j，Q，R1，R2a，R2b，R2c，R2d，R3a，R3b，R3c和R3d如本文所定义， 立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗和/或预防高胆固醇血症，良性前列腺增生，瘙痒症和癌症。
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