公开(公告)号：US20050112174A1

公开(公告)日：2005-05-26

申请号：US10951264

申请日：2004-09-27

Applicant: Robert Herrmann

Inventor： Robert Herrmann

IPC: A61L29/16 ,  A61L31/16 ,  A61K31/445 ,  A61F2/00

CPC classification number: A61L31/16 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/602

Abstract: An implantable or insertable medical device is provided which comprises (a) a superoxide dismutase mimic and (b) a polymeric release region. Upon administration to a patient, the polymeric release region controls the release of the superoxide dismutase mimic, which is beneficially selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic. Also provided is a method of making an implantable or insertable medical device.

Abstract translation: 提供了可植入或可插入的医疗装置，其包括（a）超氧化物歧化酶模拟物和（b）聚合物释放区域。 在给予患者时，聚合物释放区域控制超氧化物歧化酶模拟物的释放，其有利地选自金属螯合物超氧化物歧化酶模拟物和氮氧化物超氧化物歧化酶模拟物。 还提供了制造可植入或可插入的医疗装置的方法。

公开(公告)号：US20050038235A1

公开(公告)日：2005-02-17

申请号：US10881713

申请日：2004-06-30

Applicant: Robert Herrmann ,  David Knapp

Inventor： Robert Herrmann ,  David Knapp

IPC: C07C381/00 ,  C08B37/00 ,  C08B37/16 ,  C07C29/02 ,  C07H5/04 ,  C07K14/00

CPC classification number: C07C381/00 ,  C08B37/00 ,  C08B37/0012

Abstract: A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently mixing the solution (e.g., by vigorously stirring the solution) to produce the S-nitrosylated species; and (c) isolating the S-nitrosylated species. The nitrite-bearing species can be, for example, an inorganic nitrite, such as an alkali metal nitrite, or an organic nitrite, such as an alkyl nitrite (e.g., ethyl nitrite, amyl nitrite, isobutyl nitrite or t-butyl nitrite). The thiol is preferably a thiol-containing polysaccharide, a thiol-containing lipoprotein, a thiol-containing amino acid or a thiol-containing protein, and more preferably a thiol-containing polysaccharide such as thiolated cyclodextrin. In many preferred embodiments, the S-nitrosylated species is insoluble in the acidified solution, precipitating upon formation. The S-nitrosylated species can be isolated, for example, by a process in which the precipitate is removed from the solution (e.g., by centrifugation) and the aqueous solvent remaining in the precipitate is sublimated (e.g., by freezing the precipitate and subjecting it to a vacuum). The isolated S-nitrosylated product is preferably protected from heat, light, moisture and oxygen.

Abstract translation: 提供了生产S-亚硝基化物质的方法。 该方法包括：（a）提供包含硫醇和含亚硝酸盐的物质的脱氧碱性水溶液; （b）通过向溶液中加入酸来酸化溶液，同时混合溶液（例如通过剧烈搅拌该溶液）以产生S-亚硝基化物质; 和（c）分离S-亚硝基化物质。 含有亚硝酸盐的物质可以是例如无机亚硝酸盐，例如碱金属亚硝酸盐或有机亚硝酸盐，例如亚硝酸烷基酯（例如亚硝酸亚乙酯，亚硝酸戊酯，亚硝酸异丁酯或亚硝酸叔丁酯）。 硫醇优选为含硫醇的多糖，含硫醇的脂蛋白，含巯基的氨基酸或含硫醇的蛋白质，更优选含硫醇的多糖如硫醇化环糊精。 在许多优选实施方案中，S-亚硝基化物质不溶于酸化溶液，在形成时沉淀。 S-亚硝基化物质可以例如通过其中从溶液中除去沉淀物（例如通过离心）并且残留在沉淀物中的水性溶剂升华的方法分离（例如，通过冷冻沉淀物并使其沉淀 到真空）。 分离的S-亚硝基化产物优选保护免受热，光，水分和氧气的影响。

公开(公告)号：US5243932A

公开(公告)日：1993-09-14

申请号：US866516

申请日：1992-04-10

Applicant: Robert Herrmann

Inventor： Robert Herrmann

IPC: F02D19/08 ,  F02B3/06 ,  F02B7/02 ,  F02B47/00 ,  F02B47/02 ,  F02D41/38 ,  F02M25/022 ,  F02M43/00 ,  F02M45/04

CPC classification number: F02M25/0228 ,  F02B47/02 ,  F02B7/02 ,  F02B2201/064 ,  F02B3/06

Abstract: A fuel injection method for diesel internal combustion engines uses main injection of a gas main fuel and pilot injection of a liquid secondary fuel to initialize combustion of the main fuel. The liquid fuel is injected by an injector pump designed to enable the engine to achieve its maximum power with the liquid fuel only. The pilot injection comprises a mixture of water and liquid fuel.

Abstract translation: 用于柴油内燃机的燃料喷射方法使用主喷射气体主燃料和先导喷射液体二次燃料来初始化主燃料的燃烧。 液体燃料由注射泵注射，该注射泵设计成使得发动机仅能够利用液体燃料来实现其最大功率。 引燃喷射包括水和液体燃料的混合物。