公开(公告)号：US07108711B2

公开(公告)日：2006-09-19

申请号：US10420070

申请日：2003-04-18

申请人： Martin J. Vogel ,  Richard J. Nelson ,  Robert A. Firth ,  Anthony D. Falco ,  Joseph H. Schulman ,  Lung-Hsi Chu ,  Lee J. Mandell

发明人： Martin J. Vogel ,  Richard J. Nelson ,  Robert A. Firth ,  Anthony D. Falco ,  Joseph H. Schulman ,  Lung-Hsi Chu ,  Lee J. Mandell

IPC分类号： A61N1/04

CPC分类号： H05K3/325 ,  A61N1/14 ,  A61N2001/37294 ,  H05K3/301

摘要： A method and apparatus for protecting an electronic implantable medical device prior to it being implanted in a patient's body. The apparatus affords protection against electronic component damage due to electrostatic discharge and/or physical damage due to improper handling. The apparatus is comprised of a circuit board having a conductive surface for receiving and releasably grasping the electrodes of the medical device to support the device's housing proximate to the surface of the circuit board. Two conductive paths are formed on the circuit board extending between two conductive surfaces for shunting electrostatic discharge currents to prevent such currents from passing through the device's electronic circuitry. The conductive paths include oppositely oriented diodes, preferably comprising diodes which emit light (i.e., LEDs) when current passes therethrough. Additionally, an external monitor/generator is provided to enable functional testing of the medical device.

摘要翻译： 一种用于在电子植入式医疗装置植入患者体内之前保护电子可植入医疗装置的方法和装置。 该装置可防止由于静电放电造成的电子元件损坏和/或由于不正确的处理造成的物理损坏。 该装置包括具有导电表面的电路板，该导电表面用于接收和可释放地抓住医疗装置的电极，以支撑靠近电路板表面的装置的壳体。 在电路板上形成两个导电路径，两个导电表面之间延伸用于分流静电放电电流，以防止这种电流通过器件的电子电路。 导电路径包括相反方向的二极管，优选地包括当电流通过其中时发光的二极管（即LED）。 此外，提供外部监视器/发生器以实现对医疗装置的功能测试。

公开(公告)号：US06695885B2

公开(公告)日：2004-02-24

申请号：US10002370

申请日：2001-11-15

申请人： Joseph H. Schulman ,  Yitzhak Zilberman ,  Lee J. Mandell

发明人： Joseph H. Schulman ,  Yitzhak Zilberman ,  Lee J. Mandell

IPC分类号： A61F270

CPC分类号： A61B5/0031 ,  A61B5/0008 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/07 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/681 ,  A61B2560/0219 ,  A61B2562/08 ,  A61F2/68 ,  A61F2/72 ,  A61F2002/5058 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/37205 ,  G06F19/00 ,  Y10S977/85

摘要： A system of implantable sensor/stimulation devices that is configured to communicate with a prosthetic device, e.g., an artificial limb, via a wireless communication link, preferably bidirectionally. By communicating between the implantable devices coupled to neural pathways within a man and motor/sensor interfaces in the prosthetic device, a machine, a man/machine interface is established to replace an absent limb. Systems of the present invention may extend to prosthetic devices, e.g., cranes or the like, that further extend the man/machine interface to allow a man to control a “large” remote piece of machinery directly via neural control.

摘要翻译： 可植入传感器/刺激装置的系统，被配置为经由无线通信链路，优选双向地与假肢装置（例如，假肢）通信。 通过连接在人体内的神经通路和假体装置中的马达/传感器接口之间的可植入装置之间的通信，建立机器，人/机界面以代替缺失肢体。 本发明的系统可以延伸到假肢装置，例如起重机等，其进一步延伸人/机界面，以允许人直接通过神经控制来控制“大”远程机器。

公开(公告)号：US07670363B2

公开(公告)日：2010-03-02

申请号：US11518336

申请日：2006-09-08

申请人： Martin J. Vogel ,  Adam Vogel, legal representative ,  Richard J. Nelson ,  Robert A. Firth ,  Anthony D. Falco ,  Joseph H. Schulman ,  Lung-Hsi Chu ,  Lee J. Mandell

发明人： Martin J. Vogel ,  Richard J. Nelson ,  Robert A. Firth ,  Anthony D. Falco ,  Joseph H. Schulman ,  Lung-Hsi Chu ,  Lee J. Mandell

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61N1/14 ,  A61N2001/37294 ,  H05K3/301 ,  H05K3/325

摘要： A method and apparatus for protecting an electronic implantable medical device prior to it being implanted in a patient's body. The apparatus affords protection against electronic component damage due to electrostatic discharge and/or physical damage due to improper handling. The apparatus is comprised of a circuit board having conductive surface means for receiving and releasably grasping the electrodes of the medical device to support the device's housing proximate to the surface of the circuit board. First and second conductive paths are formed on the circuit board extending between the first and second conductive surfaces for shunting electrostatic discharge currents to prevent such currents from passing through the device's electronic circuitry. The respective shunt paths include oppositely oriented diodes, preferably comprising diodes which emit light (i.e., LEDs) when current passes therethrough. Additionally, means are provided to enable functional testing of the medical device.

摘要翻译： 一种用于在电子植入式医疗装置植入患者体内之前保护电子可植入医疗装置的方法和装置。 该装置可防止由于静电放电造成的电子元件损坏和/或由于不正确的处理造成的物理损坏。 该装置包括具有导电表面装置的电路板，该电路板用于接收和可释放地抓住医疗装置的电极，以支持靠近电路板表面的装置的壳体。 第一和第二导电路径形成在电路板之间，延伸在第一和第二导电表面之间，用于分流静电放电电流，以防止这种电流通过器件的电子电路。 相应的分流路径包括相对定向的二极管，优选地包括当电流通过其中时发光（即，LED）的二极管。 此外，提供了用于实现医疗装置的功能测试的装置。

公开(公告)号：US07071546B2

公开(公告)日：2006-07-04

申请号：US10345013

申请日：2003-03-12

申请人： Kate E. Fey ,  Charles L. Byers ,  Lee J. Mandell

发明人： Kate E. Fey ,  Charles L. Byers ,  Lee J. Mandell

IPC分类号： H01L23/02

CPC分类号： H01L25/0657 ,  H01L23/481 ,  H01L2224/05571 ,  H01L2224/05573 ,  H01L2224/13025 ,  H01L2224/131 ,  H01L2224/14181 ,  H01L2224/16146 ,  H01L2225/06513 ,  H01L2225/0652 ,  H01L2225/06541 ,  H01L2225/06572 ,  Y10T29/53104 ,  H01L2924/014

摘要： An apparatus and packaging method for stacking a plurality of integrated circuit substrates, i.e., substrates having integrated circuits formed as integral portions of the substrates, which provides interconnection paths through the substrates to simplify electrical connections between the integrated circuits while facilitating minimization of the volume and customization of the three dimensional package size to conform to the available internal space within a housing, e.g., one used in an implantabie device where package volume is at a premium. Furthermore, an internal cavity can be created by the stacked formation that is suitable for mounting of a surface mount device, e.g., a crystal or the like.

摘要翻译： 一种用于堆叠多个集成电路基板的装置和封装方法，即具有形成为基板的整体部分的集成电路的基板，其提供穿过基板的互连路径，以简化集成电路之间的电连接，同时有助于最小化该体积， 定制三维包装尺寸以符合壳体内的可用内部空间，例如，在包装体积较高的植入装置中使用的尺寸。 此外，可以通过适合于安装诸如晶体等的表面安装装置的层叠结构来产生内部空腔。

公开(公告)号：US06282444B1

公开(公告)日：2001-08-28

申请号：US09387173

申请日：1999-08-31

申请人： Mark W. Kroll ,  David W. Adinolfi ,  Lee J. Mandell

发明人： Mark W. Kroll ,  David W. Adinolfi ,  Lee J. Mandell

IPC分类号： A61N118

CPC分类号： A61N1/32

摘要： An apparatus for treating an infection which may occur in the biofilm which surrounds an implanted cardiac stimulation device, e.g., a cardioverter-defibrillator (ICD) or pacemaker. Such infections are relatively untreatable by conventional antibiotics treatments. Thus, explanting of the implanted devices may be required. Accordingly, the present apparatus provides an electrical treatment that enables a biocide, i.e., an antibiotic, to successfully treat the infection within the biofilm and thus avoid the necessity to explant the device. Furthermore, the present invention provides this electrical treatment in a manner to not interfere with the stimulation pulses of the cardiac stimulation device by alternatively delivering current pulses during atrial and ventricular refractory periods or a high frequency square wave at a frequency that exceeds the frequency response of the heart muscle.

摘要翻译： 一种用于治疗可能发生在生物膜中的感染的装置，其围绕植入的心脏刺激装置，例如心律转复除颤器（ICD）或起搏器。 这种感染通过常规抗生素治疗相对不可治疗。 因此，可能需要外植植入的装置。 因此，本发明的装置提供了使杀生物剂即抗生素能够成功地治疗生物膜内感染的电处理，从而避免了移植该装置的必要性。 此外，本发明以不超过心脏刺激装置的频率响应的频率交替地在心房和心室不适期期间递送电流脉冲或高频方波的方式来不干扰心脏刺激装置的刺激脉冲的方式提供这种电处理 心脏肌肉。

公开(公告)号：US06615082B1

公开(公告)日：2003-09-02

申请号：US09685331

申请日：2000-10-05

申请人： Lee J. Mandell

发明人： Lee J. Mandell

IPC分类号： A61N126

CPC分类号： A61N1/3712

摘要： An improved system and method for performing automatic capture/threshold detection in an implantable cardiac stimulation device or any device capable of stimulating some organ or tissue in the body. Prior art systems determine the stimulation threshold of the cardiac tissue by detecting an evoked response to a fixed duration stimulation pulse and then increasing the amplitude of the stimulation pulse by a predetermined safety margin value. Such systems are inherently based upon a belief that the chronaxie of the strength-duration curve for a particular patient is essentially fixed and that the rheobase is variable. While this may be true at some times during the patient's life, e.g., during the acute phase after lead implantation absent drug effects, it is reported that drugs alone may alter the chronaxie and it is believed that other factors may also affect the chronaxie either alone or in combination with the rheobase.

摘要翻译： 一种用于在可植入心脏刺激装置或能够刺激身体中的一些器官或组织的任何装置中执行自动捕获/阈值检测的改进的系统和方法。 现有技术系统通过检测对固定持续时间刺激脉冲的诱发反应，然后将刺激脉冲的振幅增加预定的安全余量值，来确定心脏组织的刺激阈值。 这样的系统固有地基于以下信念：特定患者的强度 - 持续时间曲线的时间基本上是固定的，并且该电流阻滞是可变的。 虽然这可能在患者生命中的某些时候是正确的，例如，在铅植入后没有药物作用的急性期，据报道，单独的药物可能会改变年龄，并且认为其他因素也可能单独影响时代 或与rheobase组合。

公开(公告)号：US07857766B2

公开(公告)日：2010-12-28

申请号：US11158166

申请日：2005-06-20

申请人： Brian J. Lasater ,  Lee J. Mandell

发明人： Brian J. Lasater ,  Lee J. Mandell

IPC分类号： A61B8/00 ,  A61B19/00 ,  A61H1/00 ,  A61F2/06

CPC分类号： A61B17/22012 ,  A61B8/56 ,  A61B2017/22002 ,  A61F2/86 ,  A61F2002/30668 ,  A61F2250/0001

摘要： A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following implantation of the stent in a patient. A plurality of electrically-powered, biocompatible devices, implantable via injection, are positioned within the patient proximate to the stent and under control of a externally-placed controller are commanded to emit ultrasonic waves corresponding to the mechanical resonance of the stent. By controlling the frequency and the relative phases of the ultrasonic waves, the accumulation of plaque on the stent can thus be minimized.

摘要翻译： 一种系统和方法，其最小化支架上的斑块积聚，从而使得在患者植入支架后可能需要随后的侵入性医疗程序的再狭窄。 多个电动生物相容性装置，可植入通过注射，位于患者内靠近支架并且在外部放置的控制器的控制下被命令发射对应于支架的机械共振的超声波。 通过控制超声波的频率和相对相位，能够使支架上的斑块积聚最小化。

公开(公告)号：US07542804B2

公开(公告)日：2009-06-02

申请号：US11004369

申请日：2004-12-03

申请人： Lee J. Mandell

发明人： Lee J. Mandell

IPC分类号： A61N1/08

CPC分类号： A61N1/3601 ,  A61N1/08 ,  A61N1/37205

摘要： A system and method that provide a prophylactic treatment to a person, e.g., a patient, to avoid the occurrence of pulmonary embolisms by the system providing neuromuscular stimulation to a person's lower extremities, e.g., the person's legs, when the system senses that a person has been immobile for an extended period of time. An implantable neuromuscular pacer, such as that described in U.S. Pat. Nos. 5,193,539; 5,193,540; 6,164,284; 6,185,452; 6,208,894; 6,315,721; 6,564,807; and their progeny, may be used to provide to selectively provide such stimulation. Preferably, such a device may be battery powered so that it can operate independent of an external apparatus. In particular, systems and devices of the present invention preferably additionally include an activity monitor, e.g., an accelerometer or the like, that disables or limits stimulation to pronged time periods in which there is limited activity.

摘要翻译： 一种系统和方法，该系统和方法为人（例如患者）提供预防性治疗，以避免当系统感觉到人的身体向人的下肢（例如人的腿）提供神经肌肉刺激时，发生肺栓塞 已经长期不动了。 可植入的神经肌肉发生器，例如美国专利号 第5,193,539号; 5,193,540; 6,164,284; 6,185,452; 6,208,894; 6,315,721; 6,564,807; 和它们的后代可用于提供选择性地提供这种刺激。 优选地，这样的设备可以是电池供电的，使得其可以独立于外部设备操作。 特别地，本发明的系统和装置优选地另外包括活动监视器，例如加速度计等，其将活动监视器禁止或限制其中有限活动的经过时间段的刺激。