公开(公告)号：US06240321B1

公开(公告)日：2001-05-29

申请号：US09133310

申请日：1998-08-12

申请人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

发明人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0565

摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal comes into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.

摘要翻译： 适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。 引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。 引线可以包括用于将电极固定到心脏组织的固定螺旋。 导线组件可以替代地包括开放的管腔引线端头。 在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。 密封件包括可膨胀基质，例如水凝胶。 当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。 密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。 结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。

公开(公告)号：US06212434B1

公开(公告)日：2001-04-03

申请号：US09120824

申请日：1998-07-22

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06321122B1

公开(公告)日：2001-11-20

申请号：US09121018

申请日：1998-07-22

申请人： Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

发明人： Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

IPC分类号： A61N100

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.

摘要翻译： 适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。 引线包括具有第一导电表面的第一远端电极。 引线体还具有具有第二导电表面的第二电极。 第二电极适于定位并固定在心脏心房的壁上。 被动固定元件可以用作第二电极的一部分。 引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

公开(公告)号：US06505082B1

公开(公告)日：2003-01-07

申请号：US09643125

申请日：2000-08-21

申请人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

发明人： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W Goebel ,  Douglas A Heitkamp ,  Randall M. Peterfeso

IPC分类号： A61N105

CPC分类号： A61N1/0573 ,  A61N1/0563

摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US06345204B1

公开(公告)日：2002-02-05

申请号：US09661531

申请日：2000-09-14

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

IPC分类号： A61N105

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.

摘要翻译： 一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。 引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。 引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。 第一和第二电极都适于定位和固定在墙上。 活性固定元件用作第二电极的一部分。 引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一实施例中，主引线体包括凹部，其中一个端部的心房引线体和主动固定元件可以从凹部 位置到固定在心脏壁上的位置。 主动固定元件也可以通过转动端子销来移动。

公开(公告)号：US06256541B1

公开(公告)日：2001-07-03

申请号：US09062268

申请日：1998-04-17

申请人： John E. Heil ,  Ronald W. Heil, Jr. ,  Avram Scheiner ,  Yayun Lin ,  Lyle A. Bye ,  J. John Lattuca

发明人： John E. Heil ,  Ronald W. Heil, Jr. ,  Avram Scheiner ,  Yayun Lin ,  Lyle A. Bye ,  J. John Lattuca

IPC分类号： A61N105

CPC分类号： A61N1/0563 ,  A61N1/0573

摘要： An endocardial lead comprising an elongate body having a first defibrillation coil electrode, a second defibrillation coil electrode and a first pacing/sensing electrode. The first defibrillation coil electrode has a first end and a second end, where the first end is at or near the distal end of the elongate body and the second end spaced longitudinally from the distal end. The first pacing/sensing electrode is spaced longitudinally along the peripheral surface from the second end of the first defibrillation coil electrode. The second defibrillation coil electrode is spaced longitudinally along the peripheral surface from the first pacing/sensing electrode to afford positioning the first defibrillation coil longitudinally adjacent an apical location of the right ventricle of a heart with the first pacing/sensing electrode within the right ventricle of the heart and the second defibrillation coil within the right atrial chamber or a major vein leading to the right atrial chamber of the heart. The elongate body further includes a curved portion on which the first pacing/sensing electrode is positioned such that the first pacing/sensing electrode extends beyond the peripheral surface of the elongate body to engage the tissue of the heart. The first pacing/sensing electrode further includes a retaining element, where the retaining element is adapted to be embedded in the right ventricle of the heart to secure the first pacing/sensing electrode and the elongate body of the endocardial lead to the right ventricle of the heart.

摘要翻译： 一种心内膜，其包括具有第一除颤线圈电极，第二除颤线圈电极和第一起搏感测电极的细长体。 第一除颤线圈电极具有第一端和第二端，其中第一端处于细长体的远端处或其附近，并且第二端与远端纵向间隔开。 第一起搏感测电极沿着与第一除颤线圈电极的第二端的外周表面纵向间隔开。 第二除颤线圈电极沿着与第一起搏/感测电极的外周表面纵向间隔开，以使第一除颤线圈与心脏右心室的顶端位置纵向相邻，其中第一起搏/感测电极位于右心室内 右心房中的心脏和第二除颤线圈或通向心脏右心房的主要静脉。 细长主体还包括弯曲部分，第一起搏/感测电极定位在弯曲部分上，使得第一起搏/感测电极延伸超出细长体的周边表面以接合心脏的组织。 第一起搏/感测电极还包括保持元件，其中保持元件适于嵌入心脏的右心室，以将第一起搏/感测电极和心内膜引导件的细长体固定到右心室 心。

公开(公告)号：US6152954A

公开(公告)日：2000-11-28

申请号：US121006

申请日：1998-07-22

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

IPC分类号： A61N1/05

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.

摘要翻译： 一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。 引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。 引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。 第一和第二电极都适于定位和固定在墙上。 活性固定元件用作第二电极的一部分。 引线体还包括有助于第二电极的定位和固定的弯曲部分。 在另一个实施例中，主引线主体包括凹部，其中安装在一端的心房引线主体和主动固定元件可以从凹陷位置行进到用于固定到心脏壁的位置。 主动固定元件也可以通过转动端子销来移动。

公开(公告)号：US20130144174A1

公开(公告)日：2013-06-06

申请号：US13674639

申请日：2012-11-12

申请人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

发明人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

IPC分类号： A61B5/0205 ,  A61B5/03 ,  A61B5/20

CPC分类号： A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

摘要： An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.

摘要翻译： 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生 以周期性间隔代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。

公开(公告)号：US07392090B2

公开(公告)日：2008-06-24

申请号：US10672315

申请日：2003-09-26

申请人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

发明人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

IPC分类号： A61N1/00

CPC分类号： A61B5/0031 ,  A61N1/30 ,  A61N1/3621

摘要： A data logging system and method in which an implantable medical device transmits logged data to an external data logging device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded data by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external data logging device. The data logging device then demodulates the sensed potentials to derive the digital data and stores the data in a data logging storage medium.

摘要翻译： 一种数据记录系统和方法，其中可植入医疗设备将记录的数据发送到具有低能量电位信号的外部数据记录装置。 可植入装置通过操作电流源产生用数字编码数据调制的电位信号，以引起可由外部数据记录装置在皮肤表面感测到的对应电位。 数据记录装置然后解调所感测的电位以导出数字数据并将数据存储在数据记录存储介质中。

公开(公告)号：US07201733B2

公开(公告)日：2007-04-10

申请号：US09999260

申请日：2001-11-30

申请人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

发明人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

IPC分类号： A61M31/00

CPC分类号： A61N1/30 ,  A61N1/3621 ,  Y10S128/12 ,  Y10S128/13

摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

摘要翻译： 一种药物递送系统，其结合到心脏装置中，用于在检测到特定医疗状况时将药物的剂量递送给患者。 心脏装置可以是例如通过射频链路与药物递送装置进行通信的可植入式心律转复器/除颤器，心脏起搏器或组合装置。 药物递送装置优选是经电调制的透皮药物递送装置，用于根据从心脏装置接收的信号透皮地递送药物。