公开(公告)号：US20230303453A1

公开(公告)日：2023-09-28

申请号：US17943596

申请日：2022-09-13

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Xinyao CUI ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Xiaolan BAI ,  Zhen WANG ,  Longhua XU ,  Dun LIU ,  Shuiquan HUANG ,  Hongtao ZHU ,  Bin ZOU

IPC: C04B35/58 ,  C04B35/626 ,  C04B35/645

CPC classification number: C04B35/58021 ,  C04B35/6261 ,  C04B35/645 ,  C04B35/6264 ,  C04B2235/3886 ,  C04B2235/3843 ,  C04B2235/3891 ,  C04B2235/405 ,  C04B2235/404 ,  C04B2235/75 ,  C04B2235/786 ,  C04B2235/785 ,  C04B2235/604 ,  C04B2235/6562 ,  C04B2235/6567 ,  B26D2001/002

Abstract: A crack self-healing functionally gradient material for ceramic cutting tools and a preparation method thereof. The material for ceramic cutting tools has a symmetrical gradient structure, and based on the percentage by mass, components of each layer include 50%-80% of Ti(C7,N3), 25%-5% of (W7,Ti3)C and 20%-0% of TiSi2; contents of components of layers that are symmetrical relative to a central layer are the same and a thickness is symmetrically distributed; a content of Ti(C7,N3) gradually increases from the surface layer to the central layer, contents of (W7,Ti3)C and Ti Si2 gradually decrease by 5% from the surface layer to the central layer, and the contents of Ni and Mo gradually increase from the surface layer to the central layer.

公开(公告)号：US20230279345A1

公开(公告)日：2023-09-07

申请号：US17851731

申请日：2022-06-28

Applicant: SHANDONG UNIVERSITY ,  YANSHAN UNIVERSITY

Inventor： Chuanzhen HUANG ,  Zhichao WANG ,  Hanlian LIU ,  Zhenyu SHI ,  Peng YAO ,  Dun LIU ,  Zhen WANG ,  Longhua XU ,  Shuiquan HUANG ,  Minting WANG ,  Hongtao ZHU ,  Bin ZOU

IPC: C12N5/00 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106

CPC classification number: C12N5/0068 ,  B33Y10/00 ,  B33Y80/00 ,  B29C64/106 ,  C12N2533/30 ,  B29L2031/7534

Abstract: A vascular structure-containing large-scale biological tissue and a construction method thereof. In the existing three-dimensional cell culture, it is contradictory for the elastic modulus of the scaffold material in ensuring structural stability and biocompatibility, and the vascular structure is required to provide channels for nutrient exchange when a large-scale structure is prepared. A cell-laden matrix material is poured into a hollow scaffold serving as a supporting scaffold. The overall stability of the scaffold structure can be ensured by regulating the mechanical properties of the supporting scaffold, thereby resolving the contradiction in ensuring structural stability and biocompatibility for the mechanical properties of the scaffold material in the conventional three-dimensional cell culture. A coaxially printing outer material contains a thermosensitive material. The removal of the outer thermosensitive material can increase the porosity of the vascular walls, and further increase the diffusion in the hollow vascular ducts.